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Popular Abstract in Swedish I dag används cellhämmande medel, cytostatika, ofta i kombination med andra metoder för behandling av vissa typer av cancer. Cytostatika kan bota t.ex. leukemi, testikel- och lymfkörtelcancer, eller lindra symtomen och förlänga livet vid t.ex. småcellig lungcancer. En grupp av cytostatika utgörs av metallkomplex där metallen är platina (Pt). Upptäckten av en sådan förenThe kinetics and mechanism for interactions of the anticancer active platinum(II) complexes cis-[PtCl2(NH3)2)], cis-[PtCl2(NH3)(c-C6H11NH2)], and trans-[PtCl2-(NH3)(quinoline)] with DNA have been studied using a combination of HPLC, circular dichroism (CD), UV/vis spectroscopy, and differential scanning calorimetry (DSC). Reactions of the monoaqua forms (charge = +1) of these complexes with single

Popular Abstract in English The work presented here is about methods that will enable more precise estimates of soil and rock parameters related to seismic hazard mapping, in particular when resources are limited. This will allow for evaluating the seismic risk in countries where earthquakes are frequent and large budgets are not available. Particularly, the study of ground response due to the eneIn sites where earthquakes occur, the use of surface wave methods represents a convenient and effective procedure for soil characterization. In particular, Multichannel Analysis of Surface Wave (MASW) has become a popular tool in many seismic micro-zoning projects. In common practice the active MASW method is implemented using a sledgehammer source and a linear receiver spread. This method is lim

Purpose: Radiotherapy of moving tumours is a great challenge in cancer treatment. The moving target will lead to “dose-smearing” of the planned dose distribution and a need for larger margins. To reduce the dose to the surrounding healthy tissue, while still ensuring full coverage of the target, other methods for motion compensation is needed. Inversely optimised arc radiotherapy, where the treatm

Background:With a rapidly ageing population, the number of wrist fractures will rise dramatically in the super-elderly (>80 years) group. In previous published studies regarding mortality after wrist fractures elderly are often defined using a rather wide age-span, the threshold has been set to somewhere between 50-70 years. However, elderly defined as a group this way is probably too imprecise. D

Popular Abstract in Swedish Vi är omringade av olika mikrorganismer såsom bakterier och svampar. Bakterier kan leva från de mest ogästvänliga miljöer som arktisk is och varma källor på havsbotten till varje människas hud och mag- tarmkanal. Bakterier som bor på och inuti oss spelar en stor roll i vårt välbefinnande. De hjälper oss att smälta maten och hindrar andra mer farliga bakterier från att bAssociation to specific host tissue structures allows pathogenic bacteria to establish an infection and facilitates the spread within its host. Interactions between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is al

Inclusive transverse momentum spectra of eta mesons have been measured within p(T)=2-10 GeV/c at midrapidity by the PHENIX experiment in Au+Au collisions at root s(NN) = 200 GeV. In central Au+Au the eta yields are significantly suppressed compared to peripheral Au+Au, d+Au, and p+p yields scaled by the corresponding number of nucleon-nucleon collisions. The magnitude, centrality, and p(T) depende

Transverse single-spin asymmetries to probe the transverse-spin structure of the proton have been measured for neutral pions and nonidentified charged hadrons from polarized proton-proton collisions at midrapidity and root s = 200 GeV. The data cover a transverse momentum (pT) range 1.0-5.0 GeV/c for neutral pions and 0.5-5.0 GeV/c for charged hadrons, at a Feynman-x value of approximately zero. T

The invariant differential cross section for inclusive electron production in p+p collisions at root s=200 GeV has been measured by the PHENIX experiment at the BNL Relativistic Heavy Ion Collider over the transverse momentum range 0.4 <= p(T) <= 5.0 GeV/c in the central rapidity region (vertical bar eta vertical bar <= 0.35). The contribution to the inclusive electron spectrum from semileptonic d

The production of deuterons and antideuterons in the transverse momentum range 1.1 < p(T)< 4.3 GeV/c at midrapidity in Au+Au collisions at root s(NN) = 200 GeV has been studied by the PHENIX experiment at RHIC. A coalescence analysis, comparing the deuteron and antideuteron spectra with that of proton and antiproton, has been performed. The coalescence probability is equal for both deuterons and a

The PHENIX experiment has measured midrapidity transverse momentum spectra (0.4

First results on charm quarkonia production in heavy ion collisions at the Relativistic Heavy Ion Collider (RHIC) are presented. The yield of J/psi's measured in the PHENIX experiment via electron-positron decay pairs at midrapidity for Au-Au reactions at roots(NN) = 200 GeV is analyzed as a function of collision centrality. For this analysis we have studied 49.3x10(6) minimum bias Au-Au reactions

We present the results of phi meson production in the K+K- decay channel from Au+Au collisions at root s(NN) =200 GeV as measured at midrapidity by the PHENIX detector at Brookhaven National Laboratory's Relativistic Heavy Ion Collider. Precision resonance centroid and width values are extracted as a function of collision centrality. No significant variation from the Particle Data Group accepted v

The transverse momentum dependence of the azimuthal anisotropy parameter v(2), the second harmonic of the azimuthal distribution, for electrons at midrapidity (vertical bar eta vertical bar < 0.35) has been measured with the PHENIX detector in Au+Au collisions at root s(NN) = 200 GeV. The measurement was made with respect to the reaction plane defined at high rapidities (vertical bar eta vertical

Popular Abstract in Swedish Typ 2 diabetes är en sjukdom där dels bukspottkörtelns förmåga att producera hormonet insulin och dels kroppens förmåga att svara på insulin (insulinkänslighet) är nedsatt. Eftersom insulin behövs för att ta upp socker (glukos) från blodet i organ som muskel och fett, är glukoskoncentrationen i blodet förhöjd hos typ 2 diabetiker. Med hjälp av olika behandlingar såsom dCardiovascular complications are frequent in type 2 diabetes (T2D) and cardiovascular death is the most common cause of death for these individuals. A region on chromosome 19 (19q13) has been indicated by several genome scans as a susceptibility locus for T2D or components of the metabolic syndrome (MetS). This gene rich region contains the gene encoding muscle glycogen synthase (GYS1), earlier as

Popular Abstract in English Disasters continue to affect urban populations and housing infrastructure. They are intensified by extreme weather events caused by climate change. This situation has made the creation of synergies between climate change adaptation (CCA) and disaster risk management (DRM) urgent. Despite their similarities and the recognised need to unite CCA and DRM efforts, the fieldsAn increasing number of disasters continue to affect urban populations and housing infrastructure. The overwhelming majority of them have been caused by climate-related events. This situation has made the creation of synergies between climate change adaptation (CCA) and disaster risk management (DRM) urgent. Despite the recognised need to unite CCA and DRM efforts, the fields remain separate. Furt

Transverse momentum spectra of neutral pions in the range 1

J/psi production has been measured in proton-proton collisions at roots=200 GeV over a wide rapidity and transverse momentum range by the PHENIX experiment at the Relativistic Heavy Ion Collider. Distributions of the rapidity and transverse momentum, along with measurements of the mean transverse momentum and total production cross section are presented and compared to available theoretical calcul

Bose-Einstein correlations of identically charged pion pairs were measured by the PHENIX experiment at midrapidity in Au+Au collisions at roots(NN)=200 GeV. The Bertsch-Pratt radius parameters were determined as a function of the transverse momentum of the pair and as a function of the centrality of the collision. Using the standard core-halo partial Coulomb fits, and a new parametrization which c

The invariant differential cross section for inclusive neutral-pion production in p+p collisions at roots=200 GeV has been measured at midrapidity (eta<0.35) over the range 1

Popular Abstract in Swedish Proteoglykaner (PG), framför allt sådana som bär glykosaminoglykan-sidokedjor av heparansulfat (HS) typ, utgör multifunktionella receptorer på cellytan och i pericellulär matrix hos alla adherenta celler i högre organismer. HS-proteoglykaner är inblandade i många olika cellprocesser, bl.a. koagulation, celltillväxt, och aktivering av enzymer, antienzymer samt bindning tThe present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. Xyl-2-Nap-6-OH inhibited growth of transformed cells to a significantly greater extent than normal cells. The growth inhibition exerted by the xy