Sökresultat

Purpose: For evaluation, development and optimization of treatment strategies in radionuclide therapy, it is useful to study and model the pharmacokinetics of the therapeutic agent. The aim of this study was to create models for describing the pharmacokinetics of monoclonal antibodies used for radioimmunotherapy.Method: Two models, based on very different modeling approaches, are presented in this

Hur rör sig bröstcancerceller i det akustiska fältet? Bröstcancer är en av dom vanligaste åkommorna som drabbar kvinnor i världen. Sjukdomens stora variation och komplexitet medför att behandlingsstrategier och hur patienten reagerar till behandlingen varierar stort mellan individerna. Det finns fortfarande mycket forskning kvar att utföra för att finna effektiva metoder för diagnostik och behandBreast cancer is one of the most common forms of cancer detected in women. Its heterogeneity and large mutational landscape requires treatment strategies which varies between patients. Triple negative breast cancer (TNBC) is a particularly aggressive subtype which 12-17 \% of breast cancer patient develop. It has no specific treatment and patients with TNBC generally has worse outcomes. To gain mo

Production of building materials is connected to a great deal of environmental degradation, and demand for materials is expected to increase. Currently, the construction industry is responsible for 23 % of the global GHG emissions, 40 % of the raw materials consumed globally, and 32 % of the waste generated in Europe. With urbanization and an increasing population, more buildings are needed in the

This paper aims to initiate a discussion on the meanings and manifestations of child-centered relatedness, with a particular focus on parents’ educational care work and how parents navigate sentiments of uncertainty and risk in relation to their children’s future. By drawing on examples from ethnographic fieldwork in East Asia, I hope to contribute to expanding the lens on the moral and emotional

Popular Abstract in French L'inquiétude grandit quant à la perte de la biodiversité liée aux changements d'utilisation des terres, l’effet de cette perte sur les services écosystémiques fournis par les communautés naturelles et semi-naturelles et, finalement, la menace que cela pourrait entraîner sur le bien-être de l’Homme. Ce travail de thèse examine l'impact de l'utilisation des terres présenteConcerns are increasing about the loss of biodiversity under land use change and how this will affect the ecosystem services provided by natural and semi-natural communities and consequently how this will threaten human well-being. The thesis examines the impact of present and past land use on different aspects of biodiversity; namely species diversity, traits and functional diversity and on ecos

Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f

Den globala jordbruksproduktionen har de senaste fem decennierna nästan tredubblats. Produktionsökningen beror på ett allt intensivare jordbruk samt konvertering av naturliga ekosystem till jordbruksmark. Intensifieringen av jordbruket har skett genom ökad användning av högavkastande grödor, mekanisering, bevattning, konstgödsel och bekämpningsmedel. Både intensivare jordbruk och expansionen av joGlobal agricultural production almost tripled within the last five decades. The production increase wasbased on expanding cropland and pastures, as well as the intensification of agriculture, including increased use ofhigh yielding crop varieties, machinery, irrigation, artificial fertilisers, and pesticides. Both, agriculturalintensification and the expansion of agricultural land-use lead to envi

The overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus gThe overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus g

Popular Abstract in Swedish Neuroblastom, när utvecklingen går fel Neuroblastom är en tumörsjukdom som drabbar små barn och i Sverige diagnosticeras ungefär 14 barn med neuroblastom varje år. Neuroblastomtumörerna utvecklas under anläggningen av det sympatiska nervsystemet, som är en del av det icke-viljestyrda nervsystemet och har till uppgift att anpassa kroppens svar på stress och fara genom atThe childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. The genesis of the SNS requires the correct expression pattern of

Popular Abstract in English Most people see chemistry as an abstract and complicated subject because it deals with species that can not be seen with bare eyes. But if one think about it, chemistry is everywhere! Chemical processes happen all around you and inside you everyday : there is chemistry in the human body where proteins play a great role, in shampoo bottles, the toothpaste, in the cement A considerable amount of mineral particles are found to have a plate-like shape. The work in this thesis concerns theoretical investigations, using Monte Carlo method, of the properties of such particles in aqueous solutions. The objectives were first to create a model that could capture the essential physics of clay suspensions and also to understand the role of thermodynamics in certain chemical

This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. The focus of the studies was to develop an efficient andconcise strat

Using transition metals in organic synthesis has led to the discovery of new reactions. These novel reactions have enabled different valuable transformations to take place through short synthetic routes and most importantly using a small amount of the metal. This small amount is called a catalytic amount and the metal which is in the form of a complex (with an array of groups of atoms bonded to thNew palladium and nickel complexes based on unsymmetric PCN pincer ligands have been synthesized and fully characterized using different techniques. The substituents on the nitrogen side arm of the ligand have great influence on the cyclometallation and the reactivity of the new complexes particularly in case of nickel. The less sterically hindered PCNMe ligand enabled formation of the trivalent n

Popular Abstract in Swedish Hur hade vår värld sett ut utan den teknologiska revolutionen som skett de senaste decennierna? Inget internet, inga mobiltelefoner, inga surfplattor? Drivkraften bakom att det hela är en väldigt liten beståndsdel som sitter i nästan all elektronik, den så kallade transistorn. En transistor kan se lite olika ut men är i stora drag en elektrisk komponent där man styr strThis thesis explores several novel material systems and innovative device concepts enabled by nanowire technology. State-of-the-art fabrication techniques such as electron beam lithography and atomic layer deposition are utilized to achieve high control and quality in the device fabrication. The devices in this thesis are based on two main types of design geometries, lateral and vertical, each of

The current paper describes the deictic system of Kamaiurá, a language of the Tupí-Guaraní family. The Kamaiurá system of deictic demonstratives and adverbials has a high degree of complexity, including at least 17 different forms, of which several have different functions. The system codes four levels of Participant deixis, with proximal, medial, distal and far distal deixis. Forms can also code The current paper describes the deictic system of Kamaiurá, a language of the Tupí-Guaraní family. The Kamaiurá system of deictic demonstratives and adverbials has a high degree of complexity, including at least 17 different forms, of which several have different functions. The system codes four levels of Participant deixis, with proximal, medial, distal and far distal deixis. Forms can also code

Popular Abstract in English A large variety of microorganisms are present in nature and have indispensable roles in recycling carbon, remediation of the environment, agriculture, and also in providing health benefits to humans. Microorganisms are microscopic versatile living factories that can consume several different natural as well as synthetic compounds for their growth and also produce differA shift from fossil- to renewable biomass feedstock for the emerging bio-based economy requires the development and adoption of new sustainable technologies that are more suited for transformation of biomass components to chemicals, materials and energy. This thesis presents investigations on the development of processes based on industrial biotechnology as a key element for the production of chem

SlutsatserTyp 1- och typ 2-diabetes Det finns ett samband mellan att äta medelhavskost och lägre risk att dö i förtid oavsett orsak (måttlig tillförlitlighet). Det finns ett samband mellan att äta en större andel2 fibrer eller baljväxter och lägre risk att dö i förtid oavsett orsak (måttlig tillförlitlighet). Det kan även finnas ett samband mellan att äta en större andel nötter och lägre risk att

At the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion bAt the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion b

Popular Abstract in Swedish Urinvägsinfektioner är en av våra vanligaste infektionssjukdommar. De orsakas främst av den Gramnegativa bakterien Escherishia coli. Normalt hålls urinvägarna sterila av ett effektivt försvar med utsöndring av antimikrobiella faktorer i urinen, men även urinflödet i sig är en viktig faktor i försvaret mot infektioner. Vissa bakterier klarar dock att etablera sig trots dIn this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. This response was independent of LPS and did not require CD14. TLR4 was abundant on epithelial cells throughout