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A first research development progress report of the Chromosome 19 Consortium with members from Sweden, Norway, Spain, USA, China and India, a part of the Chromosome-Centric Human Proteome Project (C-HPP) global initiative is presented (http://www.c-hpp.org). From the chromosome 19 peptide-targeted library constituting 6159 peptides, a pilot study was conducted using a sub-set with 125 isotope-labe
Popular Abstract in Swedish Peptidaser, proteolytiska enzymer eller proteinhydrolaser är olika benämningar på samma sorts enzymer. Deras funktion är att bryta ner proteiner i alla celler, vävnader eller vätskor i antingen vår egen kropp eller i någon annan levande organism. Varför behövs dessa enzymer? Deras funktion påminner om den av en återvinningscentral, där peptidaserna avvecklar felfungeraProteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. Among these, papain-like (C1) peptidases are the mostly studied ones. Inhibitors regulate proteolytic activit
Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning av avhandlingen Olfaction in Desert Locusts – Anatomy, Function and Plasticity of the Central Olfactory System av Rickard Ignell, Ekologiska institutionen, Lunds Universitet 2001. Doftsinnet hos ökengräshoppor Att studera ökengräshoppans, Schistocerca gregaria, doftsinne är att försöka komma underfund med några av de mekanismeThe anatomy, function and plasticity of the primary olfactory centre, the antennal lobe (AL), of the desert locust Schistocerca gregaria was investigated using a number of neuroanatomical and neurophysiological methods. Anatomical characterisation of the AL in a number of orthopteran species made it possible to deduce a model concerning the evolution of microglomeruli. These neuropil structures, c
It is attractive to integrate a large deformable mirror for adaptive optics into an astronomical telescope rather than using relay optics within an auxiliary instrument. However, the resulting large deformable mirror can be expensive, particularly for extremely large telescopes. We have pursued a low-cost approach using force actuators connected to the back of the deformable mirror through suction
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether th
The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typ
The ATLAS Transition Radiation Tracker (TRT) performance depends critically on the choice of the active gas and on its properties. The most important operational aspects, which have led to the final choice of the active gas for the operation of the TRT at the LHC design luminosity, are presented. The TRT performance expected at these conditions is reviewed, including pile-up effects at high lumino
We present an excerpt of the document "Quantum Information Processing and Communication: Strategic report on current status, visions and goals for research in Europe", which has been recently published in electronic form at the website of FET (the Future and Emerging Technologies Unit of the Directorate General Information Society of the European Commission, http://www.cordis.lu/ist/fet/qipc-sr.ht
The 17 beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large cohorts in the Breast and Prostate Cancer
We summarise the findings of arthropods collected by fogging the canopy of 24 pine trees in two sites in Eastern and Western Norway. From the samples, taken in 1998 and in 1999, almost 30,000 specimens were determined to 512 species, with Diptera being most species rich (210 species), followed by Coleoptera (76 species) and Araneae (49 species). Of the 96 new species records, nine were new to scie
The drought of 2003 was exceptionally severe in many regions of Europe, both in duration and in intensity. In some areas, especially in Germany and France, it was the strongest drought for the last 50 years, lasting for more than 6 months. We used continuous carbon and water flux measurements at 12 European monitoring sites covering various forest ecosystem types and a large climatic range in ord
Xenograft studies indicate that some solid tumors and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its relevance in humans remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which co
Allmän studieplan för utbildning på forskarnivå i humanekologi Sida 1 av 12 Fakultetsstyrelsen ALLMÄN STUDIEPLAN FÖR HÅLLBARHETSVETENSKAP Diarienummer U 2020/935 Datum 2020-11-26 Allmän studieplan för utbildning på forskarnivå i hållbarhetsvetenskap Allmän studieplan för utbildnings på forskarnivå i hållbarhetsvetenskap är fastställd av Samhällsvetenskapliga fakultetsstyrelsen 2020-11-26, dnr U 20
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2020-12/asp_hallbarhetsvetenskap_20201126.pdf - 2026-07-07
Utvecklingsplan för Mastersprogrammet i miljö- och hållbarhetsvetenskap (LUMES) Sida 1 av 10 Fakultetsstyrelsen UTVECKLINGSPLAN Diarienummer STYR 2020/2030 2022-02-03 Utvecklingsplan för Mastersprogrammet i miljö- och hållbarhetsvetenskap (LUMES) Bakgrund Våren 2021 utvärderades Mastersprogrammet i miljö- och hållbarhets- vetenskap (LUMES) vid Lund University Centre for Sustainability Studies (LUC
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2022-05/Utvecklingsplan-LUMES.pdf - 2026-07-07
IMPORTANCE: Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants' anxiety and pain. These deficiencies impair the planning and implementation of potent
