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Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There
The energy intensive industry, producing basic materials, is responsible for 25 to 30% of today's global greenhouse gas emissions. The future supply of GHG neutral basic materials (e.g. steel, cement, aluminium, plastics, etc.) is a necessity for building a sustainable modern society. Deep decarbonisation of the energy intensive industries is technically possible but will require a major systemic
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is more challenging. In this study, we manually curated 1235 SVs, which can ultimately be used to evaluate SV callers or train machine learning models. We deve
Recent research using repeat photography, long-term ecological monitoring and dendrochronology has documented shrub expansion in arctic, high-latitude and alpine tundra ecosystems. Here, we (1) synthesize these findings, (2) present a conceptual framework that identifies mechanisms and constraints on shrub increase, (3) explore causes, feedbacks and implications of the increased shrub cover in tun
Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCare
To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced these genes in diagnostic samples from 515 patients (227 AMLs and 288 ALLs). Somatic IDH1/IDH2 mutations were rare in ALL (N=1), but were more common in AML, occurring in 3.5% (IDH1 N=3 and IDH2 N=5), with the frequency h
This paper investigates receptive knowledge of English lexical collocations among Swedish high school students. The study tests the claim that L2 (second language) learners of English have a low level of collocational competence and tend to recognise high-frequent collocations more than low-frequent since the former have been encountered more. The target items for this study consisted of 40 colloc
It has for long been known that dark matter must exist in our universe. Despite massive efforts to detect dark matter, its constituents remain a mystery. One strategy to unveil this mystery is to produce dark matter by colliding Standard Model particles. The most common signature of dark matter production is an excess of missing transverse energy, MET. Such an event would be very rare, which is wh
This thesis compares the wildfire evacuation simulation programme, WUI-NITY, against real-world data by analysing and comparing three wildfire events of the past. The wildfire events were all limited to be within the state of California and was further analysed based on the available quality of data derived of the chosen database. The goal with this thesis was to setup simulations based on the evi
Svensk och dansk standard skiljer sig åt vid beräkning av pålars bärförmåga i lermorän, där den svenska metoden i tidigare undersökningar har konstaterats mest konservativ. En av anledningarna till detta är att spetsens inverkan på bärigheten beaktas vid dimensionering enligt dansk standard, men bortses från när svensk standard tillämpas. Svensk standard appliceras idag med utgångspunkt i samma me
Patent law has been prevalent in climate change discussions, as a factor linking technology, Intellectual Property Rights (IPRs) and the climate crisis. The inventive step, its set threshold and the environmental benefits for the assessment of its current state, are one of the paths where patent law can act as a potential promoter of green technologies. This paper aims to asses how patent law can
Havsnivån stiger till följd av den globala uppvärmningen. Fastigheter kommer att drabbas av översvämningar och stora fastighetsvärden kommer att påverkas. Länsförsäkringar beslutade 2018 att sluta försäkra nybyggnation av bostäder inom områden som löper risk för översvämning där länsstyrelsen har avrått från byggnation. Flera kommuner planerar för skydd av befintlig bebyggelse, men examensarbe
Skolledningsnytt nr 1/2025 från Sveriges Skolledare, lokalförening Göteborg 1 (7) Ledare: För en vecka sedan brast isen Förra onsdagen ..och det svarta, kalla vattnet slöt om kläderna. Kylan bränner mot kroppen. Trycket stiger när jag sjunker, pressar luften ur mig. Jag sjunker djupare. De spruckna isbitarna på ytan formar sig till enskilda frågor, frågor som nu inte kan besvaras. Vad hände? Idag
Denna uppsats syftar till att analysera förutsättningarna för att förbjuda förflyttningar av asylsökande inom det gällande Dublinsystemet, samt hur kompatibelt den europeiska kommissionens förslag för en Dublin IV Förordning är med mänskliga rättigheter. Dublinsystemet har till syfte att fördela skyldigheten att hantera asylansökningar mellan medlemsstaterna inom EU till en ansvarig medlemsstat. This thesis aims to analyse the prohibitions of transfers of asylum seekers in the Dublin System, and how compatible the Commission’s Proposal for a Dublin IV Regulation is with human rights law. The Dublin System is meant to allocate responsibility between Member States regarding asylum applications. After the responsible Member State has been decided according to certain criteria, the asylum see
En slitsmur är en geokonstruktion som utförs genom att paneler platsgjuts med marken som form. Panelerna bildar tillsammans en samverkande vägg. Tekniken är vanlig utomlands men fortfarande relativt ovanlig i Sverige. Behovet, och därmed intresset, av slitsmurar i Sverige växer dock i takt med förtätningen av städer och infrastrukturprojekt som kräver djup schaktning och anläggning. Kraven på låg A diaphragm wall is a retaining wall which is produced as a cast in-situ concrete wall. The ground itself acts as formwork. The technique is widely used internationally but it is comparably still a rare technique in Sweden. However, the need, and therefore interest in Sweden for diaphragm walls is growing as the number of inner city infrastructure projects requiring deep excavations increases. The
Popular Abstract in Swedish Genteknik innebär stora möjligheter att förändra och förbättra organismers egenskaper. Genom att i en organism föra in en främmande gen kan man ge den helt nya egenskaper som den aldrig skulle ha förvärvat på naturlig väg. Genmodifierade bakterier odlas idag industriellt i stora bioreaktorer för tillverkning av olika proteiner, till exempel insulin till diabetiker, humaVitreoscilla is an obligate aerobic bacterium living in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla expresses a homodimeric haemoglobin (VHb) when subjected to oxygen-limited conditions. In several organisms, expression of VHb has been shown to increase microaerobic cell growth and enhance oxygen-dependent cell metabolism. Moreover, the presence of V
Cellular communication is constantly evolving; currently 5G systems are being deployed and research towards 6G is ongoing. Three use cases have been discussed as enhanced mobile broadband (eMBB), massive machine-type communication (mMTC), and ultra-reliable low-latency communication (URLLC). To fulfill the requirements of these use cases, new technologies are needed and one enabler is massive mult
