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BackgroundThe ambulance service is facing an increased number of calls and ambulance assignments. Between 12 and 42% of all assignments result in non-conveyance to the Accident and Emergency Department. However, there is limited knowledge regarding satisfaction among patients and significant others when patients are assessed as non-urgent and discharged at the scene. Therefore, the aim of the studBackgroundThe ambulance service is facing an increased number of calls and ambulance assignments. Between 12 and 42% of all assignments result in non-conveyance to the Accident and Emergency Department. However, there is limited knowledge regarding satisfaction among patients and significant others when patients are assessed as non-urgent and discharged at the scene. Therefore, the aim of the stud

This chapter examines if identity is as important as is often claimed, and as a consequence, when and why concerns of identity are triggered in working life, and we do so through a constructionist identity perspective. In the chapter, we argue that many people do not necessarily engage with their identities most of the time and explore why they do in certain kinds of jobs and in particular situati

A user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. MoA user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. Mo

Although the involvement of the tumor suppressor gene p53 in normal hematopoiesis is uncertain, it can give rise to differentiation signals in leukemic cells. It is not clear, however, whether differentiation merely is a consequence of the ability of p53 to arrest cell proliferation or whether hitherto unknown molecular mechanisms are responsible for the p53-mediated differentiation. To further ex

Osteoarthritis (OA) constitutes a major and increasing burden on patients, health care systems and the broader society. It is estimated that around a quarter of the adult population is affected by OA in the knee and hip and that the prevalence of OA will increase over the coming decades largely due to aging and adverse life-style factors. Prevention and effective care are critical to manage the ch

BACKGROUND: Recent outbreaks of poliomyelitis caused by vaccine-derived virus have raised concerns that vaccine-derived poliovirus may continue to circulate after eradication. In these outbreaks, the virus appears to have replicated for > or =2 years before detection. Early detection is critical for an effective response to these outbreaks. Although acute flaccid paralysis (AFP) surveillance will

Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility to screen for prostate cancer (PCa). We thus conducted a transcriptome-wide association study (TWAS) of PSA levels using genome-wide summary statistics from 95,768 PCa-free men, the MetaXcan framework, and gene prediction models trained in Genotype-Tissue Expression (GTEx) project data. Tissue-specifi

In the ongoing debates about eukaryogenesis-the series of evolutionary events leading to the emergence of the eukaryotic cell from prokaryotic ancestors-members of the Asgard archaea play a key part as the closest archaeal relatives of eukaryotes 1. However, the nature and phylogenetic identity of the last common ancestor of Asgard archaea and eukaryotes remain unresolved 2-4. Here we analyse di

Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine

Sorption isotherms describe the relation between the equilibrium moisture content of a material and the ambient relative humidity. Most materials exhibits sorption hysteresis, that is, desorption give higher equilibrium moisture contents than absorption at equal ambient climate conditions. Sorption hysteresis is commonly evaluated by determination of an absorption isotherm followed by desorption sSorption isotherms describe the relation between the equilibrium moisture content of a material and the ambient relative humidity. Most materials exhibits sorption hysteresis, that is, desorption give higher equilibrium moisture contents than absorption at equal ambient climate conditions. Sorption hysteresis is commonly evaluated by determination of an absorption isotherm followed by desorption s

BACKGROUND: Palliative sedation is used to relieve refractory symptoms and is part of clinical practice in Sweden. Yet we do not know how frequently this practice occurs, how decision-making takes place, or even which medications are preferentially used.OBJECTIVES: To understand the current practice of palliative sedation in Sweden.METHODS: We conducted a retrospective cross-sectional medical reco

Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR-Cas9-mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing by the HUSH complex. HUSH recruits MORC2 to target sites in heterochromatin. We ex

Animals in seasonal environments must prudently manage energyexpenditure to survive the winter. This may be achieved throughreductions in the allocation of energy for various purposes (e.g.thermoregulation, locomotion, etc.). We studied whether such tradeoffsalso include suppression of the innate immune response, bysubjecting captive male Svalbard ptarmigan (Lagopus mutahyperborea) to bacterial li

Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow-derived T cells do not mediate severe GVHD because of their quantity and/or phenotype. During the course of experiments testing the impact of housing temperatures on GVHD, we discovered

With the increased pressure and challenges of economic, environmental, and social character, the need for innovations (including both thegeneration and adoption of innovations) that can be implemented in supply chains increases. A number of novel concepts focusing onintelligent logistics and packaging systems are being developed and tested in the food industry, all over the world. Several of theseWith the increased pressure and challenges of economic, environmental, and social character, the need for innovations (including both the generation and adoption of innovations) that can be implemented in supply chains increases. A number of novel concepts focusing on intelligent logistics and packaging systems are being developed and tested in the food industry, all over the world. Several of the

SAMMANFATTNING Bakgrund: Det är vanligt att både studenter och teknikkonsulter upplever stress i sin vardag. Stressnivån kan variera bland annat beroende på ålder och kön. Livstidsprevalensen för nackbesvär är 50-70 % och för ländryggsbesvär 80 %. Besvären drabbar oftare kvinnor. Studier har visat att fysisk aktivitet har en skyddande effekt mot stress och muskuloskelettala besvär. Syfte:Syftet va

Bakgrund: Bruk av tobak, narkotika och alkohol förekommer bland ungdomar i åldrarna 12-18 år, vilka samtliga har påvisats har en negativ effekt på hälsan. Tobaksrökning är starkt kopplat till sjukdomar som KOL, lungcancer, hjärt-och kärlsjukdomar samt diabetes medan bruk av narkotika och alkohol kan ha en fysisk och kognitiv påverkan. Även fysisk inaktivitet och stillasittande ökar bland barn och

Syftet med denna uppsats har varit att utreda internetleverantörers ansvar vid tredje mans upphovsrättsintrång då internetleverantörer tillhandahåller internetuppkoppling till sådant intrång. Uppsatsen har också klargjort vilka upphovsrättsintrång som kan aktualisera internetleverantörers ansvar, samt vilka åtgärder företagen kan tvingas vidta för att förhindra förevarande intrång. Internet möjliThe purpose with this paper has been to examine internet service providers, also known as ISP:s, responsibility when they operates as an intermediate during third party copyright infringement. The essay has also investigated which copyright infringements that actualize such responsibility and what measures may be required by ISP:s to prevent copyright infringements. Today the internet makes copyr

The wildlife park Kolmården in Norrköping, Sweden, asked for a device that could visually feedback how dolphins use their ultrasound signals while echolocating objects. By recording the sound from the dolphin, process the sound and then create a visual feedback by having LED's flash in different frequencies, depending on the distance between dolphin and device. The purpose of the device is hav