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In a multicentre phase III study of disseminated malignant melanoma performed in Sweden and Norway, 326 patients were randomised to receive treatment with the combination dacarbazine [DTIC] (D) and vindesine (V) with or without the addition of cisplatin (P). D was given intravenously (i.v.) at a dose of 250 mg/m2 days 1-5 every 4 weeks and V was given i.v. at a dose of 3.0 mg/m2 day 1 weekly. P wa
Background The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population-based study examined the relationship between RSA during deep breathing and coronary atherosclerosis, assessed by coronary artery calcium score (CACS). Methods and Resul
Forests are key components of European multifunctional landscapes and supply numerous forest ecosystem services (FES) fundamental to human well-being. The sustainable provision of FES has the potential to provide responses to major societal challenges, such as climate change, biodiversity loss, or rural development. To identify suitable strategies for the future sustenance of FES, we performed a s
Although the involvement of the tumor suppressor gene p53 in normal hematopoiesis is uncertain, it can give rise to differentiation signals in leukemic cells. It is not clear, however, whether differentiation merely is a consequence of the ability of p53 to arrest cell proliferation or whether hitherto unknown molecular mechanisms are responsible for the p53-mediated differentiation. To further ex
Osteoarthritis (OA) constitutes a major and increasing burden on patients, health care systems and the broader society. It is estimated that around a quarter of the adult population is affected by OA in the knee and hip and that the prevalence of OA will increase over the coming decades largely due to aging and adverse life-style factors. Prevention and effective care are critical to manage the ch
BACKGROUND: Recent outbreaks of poliomyelitis caused by vaccine-derived virus have raised concerns that vaccine-derived poliovirus may continue to circulate after eradication. In these outbreaks, the virus appears to have replicated for > or =2 years before detection. Early detection is critical for an effective response to these outbreaks. Although acute flaccid paralysis (AFP) surveillance will
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility to screen for prostate cancer (PCa). We thus conducted a transcriptome-wide association study (TWAS) of PSA levels using genome-wide summary statistics from 95,768 PCa-free men, the MetaXcan framework, and gene prediction models trained in Genotype-Tissue Expression (GTEx) project data. Tissue-specifi
In the ongoing debates about eukaryogenesis-the series of evolutionary events leading to the emergence of the eukaryotic cell from prokaryotic ancestors-members of the Asgard archaea play a key part as the closest archaeal relatives of eukaryotes 1. However, the nature and phylogenetic identity of the last common ancestor of Asgard archaea and eukaryotes remain unresolved 2-4. Here we analyse di
Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how mRNA vaccination of convalescents provides protection from emerging virus variant. From the cohort of 71 convalescent plasma donors, we identified a patient who developed immune response to infection with SARS-CoV-2 variant of 20A clade and who subsequently received mRNA vaccine
BACKGROUND: Palliative sedation is used to relieve refractory symptoms and is part of clinical practice in Sweden. Yet we do not know how frequently this practice occurs, how decision-making takes place, or even which medications are preferentially used.OBJECTIVES: To understand the current practice of palliative sedation in Sweden.METHODS: We conducted a retrospective cross-sectional medical reco
Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR-Cas9-mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing by the HUSH complex. HUSH recruits MORC2 to target sites in heterochromatin. We ex
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow-derived T cells do not mediate severe GVHD because of their quantity and/or phenotype. During the course of experiments testing the impact of housing temperatures on GVHD, we discovered
BACKGROUND: Pediatric cancer diagnosis and treatment reduce Health-Related Quality of Life (HRQoL). The Pediatric Quality of Life (PedsQL) Cancer Module is the most commonly used cancer specific HRQoL instrument, but most studies included relatively small cohorts and no reference scores are available. The development of a PedsQL Cancer Module benchmark, based on a large population of pediatric can
BACKGROUND: Risk stratification tools for paediatric community-acquired pneumonia (CAP) in well-resourced settings are scarce. We prospectively developed models to predict CAP severity within a multinational cohort of paediatric emergency departments (EDs). Our primary objective was to develop a risk prediction model to discriminate between mild CAP and moderate or severe CAP to assist clinicians
LUNDS UNIVERSITET CFE Conference Papers Series No. 6 ISSN: 1654-2185 Printed by M edia-Tryck Lund 2013 ED ITO R S: B A R B A R A TÖ R N Q U IST-PLE W A A N D IN G R ID R A SC H M inne och M anipulation om det kollektiva m innets praktiker N o. 6 MINNE OCH MANIPULATION OM DET KOLLEKTIVA MINNETS PRAKTIKER REDAKTÖRER: BARBARA TÖRNQUIST-PLEWA OCH INGRID RASCH CENTRUM FÖR EUROPAFORSKNING VID LUNDS UNIV
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfecp6.pdf - 2026-07-13
Lägg till titel 2023-07-05 Dnr STYR 2022/2735 Förstudie om kompetens- och karriärutveckling för teknisk och administrativ personal En rapport av Åsa Berglund Sammanfattning Denna förstudie har målet att presentera ett beslutsunderlag för hur ett långsiktigt arbete med kompetens- och karriärutveckling för teknisk och administrativ personal kan läggas upp. I förlängningen är målet att långsiktigt sä
Naturvetenskaplig kandidatexamen 1. Identifikation 1:1 Utbildningsprogram för Naturvetenskaplig kandidatexamen Huvudområden: - Biologi - Fysik - Geologi - Kemi - Matematik - Miljövetenskap - Molekylärbiologi - Naturgeografi och ekosystemanalys Study programme for Bachelor of Science (180 credits) Major: - Biology - Physics - Geology - Chemistry - Mathematics - Environmental Science - Molecular Bio
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/naturvetkandidatht2013.pdf - 2026-07-13
Tillgänglighetsanpassa PDF:er med Acrobat Pro 2021-04-06 Sidan 1 av 8 Tillgänglighetsanpassa PDF:er med Acrobat Pro Dokument som ska publiceras online som PDF måste anpassas för tillgänglighet. Lunds universitets Indesign- och Wordmallar är förberedda för detta. Förbered och exportera dina originaldokument enligt de instruktioner som medföljer mallarna. Exporterad PDF kräver i de flesta fall efte
https://www.lusem.lu.se/internal/sites/lusem.lu.se.internal/files/2024-01/instruktioner-tillganglighet-acrobat.pdf - 2026-07-13
