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Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons. It is, however, unclear whether L1 sequences are mobile in only some neuronal lineage
The retrotransposon Long Interspersed Element 1 (LINE-1 or L1) is a continuing source of germline and somatic mutagenesis in mammals. Deregulated L1 activity is a hallmark of cancer, and L1 mutagenesis has been described in numerous human malignancies. We previously employed retrotransposon capture sequencing (RC-seq) to analyze hepatocellular carcinoma (HCC) samples from patients infected with he
Hexavalent chromium Cr(VI) is a human carcinogen, but the current exposure to Cr(VI) at Swedish workplaces is unknown.Recruitment of 113 workers with potential Cr(VI) exposure and 72 controls was combined with measurements of inhalable Cr(VI) (only exposed workers) and total Cr in urine and red blood cells (RBC), Bayesian analysis of occupational exposure limit (OEL) compliance was used, as well a
The ability of lentiviral vectors to transfer genes into human hematopoietic stem cells was studied, using a human immunodeficiency virus 1 (HIV-1)-derived vector expressing the green fluorescence protein (GFP) downstream of the phosphoglycerate kinase (PGK) promoter and pseudotyped with the G protein of vesicular stomatitis virus (VSV). High-efficiency transduction of human cord blood CD34(+) cel
BACKGROUND: It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis.DESIGN: The design of this study was as a cros
INTRODUCTION: A granular understanding of the mechanisms linking tau pathology to cognitive decline in Alzheimer's disease is crucial. We investigate mediating effects of medial temporal lobe (MTL) and neocortical neurodegeneration on tau-induced domain-specific cognitive impairment in amyloid-beta (Aβ) positive cognitively normal and impaired adults.METHODS: We assessed magnetic resonance imaging
Background and aimsElevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.Met
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstr
Despite the glimmer of hope provided by the discovery and commercialization of bone morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of supraphysiological doses have hindered its clinical usage. In this study, we compared the osteoinductive potential of BMP-2 homodimer with a heterodimer of BMP-2/7, both delivered via a collagen-hydroxyapatite (CHA) scaff
Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).
Parkinson's disease (PD) is characterized by progressive loss of nigral dopaminergic neurons, resulting in disabling motor symptoms. Intracerebral transplantation of stem cell-derived dopaminergic progenitors to replace lost endogenous dopaminergic neurons offers a new potentially restorative therapeutic approach for PD. Here we report the 12-month primary safety end point and interim efficacy out
Personlig träning i Lund - Gerdahallen MoreMenu_white Group 3 Utbud Schema/Boka Sv English Bli medlem Logga in MoreMenu_white Group 3 Utbud Schema/Boka Sv English Meny English ( Engelska ) Utbud Schema/Boka Företag Kurser/föreläsningar Om oss Kontakt Lund Lund Helgonavägen 8 SE-223 62 LUND 010-722 21 00 kundservice@gerdahallen.com Lund Meny Utbud Gym Gruppträning Personlig träning Massage Gravid/m
https://gerdahallen.com/personlig-traning-lund/ - 2026-10-19
Lu ¡¡ os HUMANTSTISK.A OCH TEOLOGISKA FAKUTTETERNA PROTOKOLL Sida 1 av 3 Datum: 2022-01-18 Sammanträdestid: kl. 09.00- 12.00 Plats: Digitalt möte via Zoom universitetslektor universitetslektor universitetslektor student universitetslektor student student ordförande fakultetsstudievägledare kvalitetssamordnare fakultetssekreterare sekreterare utbildningsledare sektionsföreståndareSOL2 ç 120 represe
https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/protokoll/GUBN/Protokoll_2022.pdf - 2026-10-19
Semantic priming has been studied for nearly 50 years across various experimental manipulations and theoretical frameworks. Although previous studies provide insight into the cognitive underpinnings of semantic representations, they have suffered from small sample sizes and a lack of linguistic and cultural diversity. In this Registered Report, we measured the size and the variability of the seman
Rapport från besök hos Professor Ruan Yan, Öronkliniken, 1st Affiliated Hospital, University of Chinese Medicine, Jichen Road 16, Baiyun Area, Guangzhou, China 6 maj, 2019 Bakgrund Som tidigare skrivits i rapport till Er har universitetet South China Normal University (SCNU), där vi arbetar nu sedan snart 8 år, ingen medicinsk fakultet, vilket gjort det något svårare att finna medicinska samarbets
https://www.mlc.lu.se/fileadmin/mlc/Minnesanteckningar/Rapport_fran_besok_hos_Professor_Ruan_Yan_190506.pdf - 2026-10-19
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. T
