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The hygroscopic properties play a vital role for the direct and indirect effects of aerosols on climate, as well as the health effects of particulate matter (PM) by modifying the deposition pattern of inhaled particles in the humid human respiratory tract. Hygroscopic Tandem Differential Mobility Analyzer (H-TDMA) instruments have been used in field campaigns in various environments globally over
BackgroundA common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated.MethodsWe investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-
I vissa fall uppfattas betalda samarbeten med influencers som genuina rekommendationer och som ett effektivt sätt att påverka konsumentens köpintention. Dock understryks oro för hur betalda samarbeten vilseleder konsumenten genom sublima budskap som sprids genom influencers. Inte bara forskare ifrågasätter trovärdigheten i det som kommuniceras genom betalda samarbeten på sociala medier, utan även
Temat för denna uppsats är fördomar, och hur de påverkar oss i vårt identitetsskapande. Min hypotes är att vi bildar vår identitet utifrån den Andre, och genom de fördomar vi har om den Andre påverkas vårt identitetsskapande i en positiv riktning. Fördomar bygger enligt mig på en ojämn maktbalans, vilken gör att vi skapar fördomar mot människor i vår utgrupp. Det är mot utgruppen våra negativa för
BACKGROUND: Conversations regarding health behaviours, mental health, and socioeconomic contexts are recommended during prenatal visits to optimize maternal and fetal health outcomes. This study was designed to develop and evaluate the acceptability of a clinical dialogue tool called Conversation Cards for Pregnancy (PregnancyCards for short). PregnancyCards are being designed as a practical, pers
Justitiedepartementet har lagt fram en promemoria i vilken ett förslag om utökat byråjäv tas upp. Om förslaget går igenom innebär det att de, i småföretag, vanliga kombiuppdragen förbjuds. Många småföretag skulle därmed behöva anlita ytterligare en revisionsbyrå med ökade kostnader som följd. För att underlätta för småföretagen har det föreslagits att revisionsplikten för dessa ska slopas. Syftet
Skiljedomsrätt är sedan urminnes tider en använd tvistelösningsmetod. Hänvisningar till skiljerätt finns att hitta i både romersk och gammalgrekisk rätt, så som Digesta, Codex Iustinianus och Novellae. Även Sverige har en lång tradition av kommersiellt skiljeförfarande och metoden har nyttjats som ända sedan Hansan etablerades. Förmodligen har skiljeförfarandet även använts för att avgöra kommersiArbitration is an immemorial dispute settlement method with references to be found in both Roman and ancient Greek law, such as Digesta, Codex Iustinianus and Novellae. Sweden also has a long tradition of commercial arbitration and it has been used as a dispute settlement method at least since the Hanseatic League was established. It is also believed that arbitration was used to settle commercial
Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w
Glutamic acid decarboxylase antibodies (GADAbs) are being increasingly used in clinical and research programs for the prediction and classification of insulin-dependent diabetes mellitus (IDDM). A number of different assay formats for the measurement of GADAbs have been reported, but the degree of concordance between assays is unknown. In this study, GADAbs were measured on 16 coded sera in 34 ass
We aimed to test the hypothesis that gluten might be associated with the development of islet cell autoimmunity. A random sample of 200 persons (87 males, mean age 42.4 years) from Estonia including one patient with type I diabetes mellitus was studied. IgG-type glutamic acid decarboxylase (GAD65) antibodies were determined using radioligand-binding assay and IgG/IgA-type gliadin antibodies (AGA)
A search for an antigen-driven expansion of T lymphocytes in the inflamed joints in rheumatoid arthritis (RA) patients have been going on for decades. We here analyzed the human germinal centre T-cell receptor (TCR) Vbeta gene usage with polymerase chain reaction (PCR) combined with sequence analysis, to address the question of clonality in tonsils and synovial tissue from RA patients. Our data sh
The stability of established memory T helper (Th)1/Th2 cells in chronic inflammatory diseases is not clear, and a shift of the cytokine balance could control chronic inflammation. In order to study the regulation of the Th phenotype of memory T cells, polyclonal T-cell lines and clones with a Th1, Th0 or Th2 phenotype were developed from rheumatoid synovial tissue. Th1 [interleukin (IL)-12 + anti-
Transmembrane heparan sulfate proteoglycans regulate multiple aspects of cell behavior, but the molecular basis of their signaling is unresolved. The major family of transmembrane proteoglycans is the syndecans, present in virtually all nucleated cells, but with mostly unknown functions. Here, we show that syndecans regulate transient receptor potential canonical (TRPCs) channels to control cytoso
All cells of the musculoskeletal system possess transmembrane syndecan proteoglycans, notably syndecan-4. In fibroblasts it regulates integrin-mediated adhesion to the extracellular matrix. Syndecan-4 null mice have a complex wound repair phenotype while their fibroblasts have reduced focal adhesions and matrix contraction abilities. Signalling through syndecan-4 core protein to the actin cytoskel
BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.METHODS: We included 3316 children from a
Windstorms are considered the main disturbing abiotic agent in European forests. They affect a multiplicity of forest-related dimensions, such as forest ecology, forest operations, geomorphology, economy, and socio-cultural aspects. Due to the complex dynamics set off by windstorms, the design of post-windstorm forest management should be characterized by an interdisciplinary approach able to addr
OBJECTIVE: To investigate the feasibility of synchrotron radiation-based phase contrast enhanced micro-computed tomography (SR-PhC-μCT) for imaging of human meniscus. Quantitative parameters related to fiber orientation and crimping were evaluated as potential markers of tissue degeneration.DESIGN: Human meniscus specimens from 10 deceased donors were prepared using different preparation schemes:
The preservatives imidazolidinyl urea (IMID, Germall 115) and diazolidinyl urea (DU, Germall II) are commonly used in cosmetic products and are well-known sensitizers. The aim of the present study was to establish the optimal patch test concentration in hydrophilic dried-in vehicle (TRUE Test) for IMID and DU. 181 patients were included in the study. Of these, 150 were patients referred for patch
