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Abstract – Introduction: Stroke is a leading cause of morbidity and mortality globally, with Africa bearing a disproportionately high burden of poor outcomes. In sub-Saharan Africa, acute stroke care remains inconsistent, with organized stroke units being either absent or rarely available, contributing to the high stroke mortality rates in the region. To address this issue, the Tanzania Stroke Pro
BACKGROUND: Postmortem MRI has opened-up avenues to study brain structure at ultra high-resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple-mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem MRI. Additionally, we provide a framework to perform point-wise surface-based group-level studi
Background: SARS-CoV-2 remains globally circulating, yet post-pandemic comprehensive molecular, serological, and population-level immunity data from low-resource settings such as Ethiopia are limited. This study employed genomic surveillance with seroepidemiological assessment to characterize the epidemiology of SARS-CoV-2 among individuals presenting with influenza-like illness (ILI) and severe a
Importance: Understanding the relationship between patients' clinical characteristics and outcomes is fundamental to medicine. When critically ill patients die after withdrawal of life-sustaining therapy (WLST), the inability to observe the potential for recovery with continued aggressive care could bias future clinical decisions and research. Objective: To quantify the frequency with which expert
There is broad consensus that disciplinary higher education must include artificial intelligence (AI) content tailored to the needs of different domains. Such an approach to higher education will help cultivate the skills, knowledge and critical thinking necessary for the socially beneficial development and integration of AI into the routines, organisations and infrastructures that shape society.
Yellow peas possess an excellent nutritional profile with a high protein content and fermentation, enhancing the flour's functional and physicochemical properties. This study evaluated the impact of Solid-State Fermentation (SSF) with Rhizopus delemar (formerly known as Rhizopus oryzae) and Submerged State (SmF) with Lactiplantibacillus plantarum on yellow pea flour, alongside its application
As climate change threatens the balance in the arctic and adjacent regions, ecosystems face a multifaceted wave of change. In areas like Scandinavia, extensive glacial retreat has been observed, onset by warming temperatures. Simultaneously as plant-life responds to a changing climate, noticeable shifts have occurred in the spatial distribution of vegetation. Thus, with deglaciation revealing new
Variations in groundwater levels result from several complex hydrological processes (such as precipitation, evapotranspiration and groundwater-surface water interactions), and the groundwater response depends on factors including topography and physical properties related to the geology of the aquifer. By studying time series of hydrogeological data, such as groundwater levels and precipitation, i
The ongoing 2023 Israel-Hamas War has severe and far-reaching consequences for the people, economy, food security, and environment. The immediate impacts of damage and destruction to cities and farms are apparent in widespread reporting and first-hand accounts from within the Gaza Strip. However, there is a lack of comprehensive assessment of the war's impacts on key Gazan agricultural land that a
The documented artistic research project (doctoral thesis), Many Maids Make Much Noise, comprises a series of artistic projects focused on the social history of the early twentieth-century British militant campaign for votes for women (known as the suffragette movement). The aim is to try out artistic and educational strategies used within that movement, as a means of ‘reading’ these practices and
IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a
As cities increasingly turn to nature-based solutions (NBS) as panaceas for addressing climate challenges and other social, economic, and environmental issues, questions of urban governance and justice have become more prominent. While much of the existing literature on NBS justice assessments focuses on distributional aspects through quantitative methods, procedural justice remains underexplored,
Background: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health. Methods: Data from the World Populati
IMPORTANCE Upper gastrointestinal bleeding is common after myocardial infarction. OBJECTIVE To determine whether routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction reduces bleeding events and improves clinical outcomes. DESIGN, SETTING, AND PARTICIPANTS A nationwide, open-label, 2-period, 2-sequence, cluster randomized, crossover clinical trial usi
BACKGROUND: Prediction models for sentinel lymph node (SLN) status could potentially substitute surgical axillary staging in patients with early breast cancer. Several imaging modalities have been used with various feature extraction and selection approaches. This systematic review and meta-analysis aimed to evaluate prediction models for SLN status based on breast imaging in patients with early b
IMPORTANCE Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality. OBJECTIVE To study the association between sodium intake and incident atrial fibrillation (AF). DESIGN, SETTING, AND PARTICIPANTS This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global End
Importance: Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility. Objective: To explore differences in risk of early prostate cancer death among men with higher vs lower genetic risk to inform prevention efforts. Design, Setting, and Participants: This cohort study used a c
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 elig
