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Large-scale biobanks and electronic health records (EHR) offer great opportunities for next-generation genetic studies. However, missing phenotype data is a pervasive feature of EHR, leading to low power of such studies. One promising solution is prediction-powered inference, where statistical or machine learning models are employed to impute phenotypes prior to performing genetic analyses. Althou
Hur beskriver personer med normbrytande funktionalitet sin sexualitet, och vilka hinder möter de i sina försök att leva ut sin sexualitet på egna villkor? Denna artikel analyserar sådana erfarenheter genom ett intersektionellt och cripteoretiskt perspektiv, där funktionalitet behandlas som en analytisk kategori i egen rätt. Genom kvalitativa intervjuer med 65 personer med olika typer av normbrytan
This article examines two closely related questions. The first concerns the limits of an arbitral tribunal’s authority to interpret the parties’ procedural acts, particular-ly pleadings of facts. It is argued that a fact may be treated as pleaded only where the party’s intended procedural effect has been expressed clearly and unequivocal-ly. Where uncertainty remains, the tribunal should ordinaril
This article examines how three women from the Hebrew Bible (Jezebel, Delilah, and Eve) are framed in material that relates to Christian anti-feminist and manosphere discourse: a sermon published online by US pastor Mark Driscoll, two videos on the YouTube channels God for Purpose and Manosphere Highlights Daily, and Canadian psychologist Jordan B. Peterson’s book We Who Wrestle with God: Percepti
Introduction: Adnexal surgery is one of the most common surgeries performed in women. Minimally invasive methods are on the rise globally as they have been shown to decrease surgical morbidity compared with abdominal surgery. Adnexal surgery by vaginal natural orifice transluminal endoscopic surgery (vNOTES) is the latest innovation. It combines the vaginal approach and endoscopy via the vagina. L
The theory of water hammer is well developed and can support quantitative assessment in engineering studies. However, in the Swedish water and wastewater sector, water hammer analysis is often overlooked during the design of pressurized pipe networks. Apart from a study from the 1980s, the status of knowledge on water hammer has, to the authors' knowledge, been mapped neither in Sweden nor interna
Boreal forests mitigate climate change by sequestering atmospheric carbon. Recent declines in the boreal carbon sink and tree growth suggest that this mitigating influence is weakening, yet the underlying drivers remain unresolved. Increasing drought frequency is one likely driver. Yet most studies have focused on managed forests, overlooking the significant but shrinking areas of old-growth fores
West Nile virus (WNV) is a growing risk to public and veterinary health in Europe, with intensifying outbreaks over recent decades coinciding with a rapidly warming climate. Thermal biology models parameterized through laboratory experiments on the mosquito vectors and the pathogen play a central role in our causal understanding of the effects of temperature on WNV transmission. We evaluated the a
Introduction – Determining the etiology of community-acquired pneumonia (CAP) is essential for targeted treatment and optimal care. Reliable results require selection of the appropriate sampling site. Methods – Paired nasopharyngeal (NP) and oropharyngeal (OP) swabs were collected from 484 patients with CAP between September 2016 and September 2018. The samples were analyzed by PCRs for Streptococ
Background – While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mislocalization leads to cryptic exon inclusion and loss of canonical protein function. While neuronal
Forest above-ground biomass (AGB) estimation is crucial for evaluating carbon dynamics. Although optical and synthetic aperture radar (SAR) data provide complementary spectral and structural information, limitations in existing fusion approaches restrict AGB estimation accuracy. This study proposes a multi-source data fusion framework comparing two image fusion strategies—the conventional Hue-Inte
Generative AI promises substantial productivity gains, but many initiatives fail. This column argues that outcomes depend on readiness, not technology alone. We examine AI transformation requirements across organizational, individual, and technological dimensions, highlighting why engineering practices, human factors, and strategic clarity determine success.
Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and systemic inflammation. Increasing evidence suggests that the gut microbiome may play a role in the pathophysiology of PE. However, previous studies on the gut microbiome have generally overlooked the distinction between subgroups of PE, although clinical manifestations may differ. Also, most studi
p27, a cyclin-dependent kinase inhibitor, functions as a tumour suppressor in the nucleus but may acquire oncogenic properties when mislocalized to the cytoplasm. While KRAS mutations can induce p27 phosphorylation and cytoplasmic retention, the regulation and significance of p27 expression in wild-type (WT) KRAS colorectal cancer (CRC) remain unclear. This study investigated the relationship betw
Low- and middle-income countries are expanding health insurance to enhance financial protection. However, there is scarcity of evidence on the stakeholder perceptions towards health insurance. This study explores stakeholders' perceptions towards the implementation of the National Health Insurance Scheme in Zambia. This qualitative study is based on 21 in-depth interviews with key stakeholders inv
