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BACKGROUND: The dystrophin gene, which is mutated in Duchenne muscular dystrophy (DMD), encodes a large cytoskeletal protein present in muscle fibers. While dystrophin in skeletal muscle has been extensively studied, the function of dystrophin in vascular smooth muscle is less clear. Here, we have analyzed the role of dystrophin in injury-induced arterial neointima formation. METHODOLOGY/PRINCIPAL
Background: Uveal melanoma is the most common primary intraocular malignancy in adults. Despite successful control of the primary tumor, metastatic disease will ultimately develop in approximately 50% of patients, with the liver being the most common site for metastases. The median survival for patients with liver metastases is between 6 and 12 months, and no treatment has in randomized trials eve
The Swedish pulp and paper industry has gone through a strategic change in its approach to electricity production and consumption over the past decade. This paper documents this reorientation, which includes increased on-site electricity production, investments and investment plans for wind power, and new partnerships concerning investments in electricity production assets. We also assess the exte
The European Stroke Organisation held its first European Stroke Science Workshop in Garmisch-Partenkirchen, Germany (December 15-17, 2011). Stroke experts based in Europe were invited to present and discuss their current research. The scope of the workshop was to review the most recent findings of selected topics in stroke, to exchange ideas, to stimulate new research, and to enhance collaboration
Hg-206 was populated in the fragmentation of an E/A = 1 GeV Pb-208 beam at GSI. It was part of a campaign to study nuclei around Pb-208 via relativistic Coulomb excitation. The observation of the known isomeric states confirmed the identification of the fragmentation products. The isomeric decays were also used to prove that the correlations between beam identification detectors and the AGATA gamm
The metabolic syndrome (MS) is an important risk factor for graft dysfunction and patient death after renal transplantation. The aim of this sub-analysis of the Symphony study was to assess the progression of the laboratory parameters associated with MS in the first year after transplantation. Data collected from the Symphony study were used; 1645 patients were randomized to receive standard-dose
1.. Implementation of the full spectra of screening tools to prevent the introduction of invasive species results in a need to evaluate the cost-efficiency of gathering the information needed to screen for these species. 2. We show how the Bayesian value of information approach can be used to derive the benefit of a screening model based on species traits, which in combination with the base rate o
We present a series of experimental results that disclose the crucial role of ionic strength and partial volume fractions in the control of the phase behaviour of binary protein mixtures. Our findings can be understood as that the ionic strength determines the relative contribution of the entropy of the protein counter-ions to the overall thermodynamics of the system. Associative phase separation
This chapter ". . . looks at a problem that is an important effect of systemic features: the problems of defining clear boundaries between different types of actors. Richard Langlais and Sharon Rider study the boundary between research performed by public universities and companies basing their technology on scientific research. They use the concept "science machines" to depict those systems of so
Optimisation of cheese yield is crucial for cheese production; a previous study showed large variations in chymosin-induced coagulation in milk from the second most common Swedish dairy breed, Swedish Red. In the present study, the effect of gross composition, protein composition, total and ionic calcium content, phosphorous content and casein micelle size on chymosin-induced gelation was determin
We study the Ginzburg-Landau model of superconductivity in three dimensions and for strong external magnetic fields. For magnetic field strengths above the phenomenologically defined second critical field it is known from Physics that superconductivity should be essentially restricted to a region near the boundary. We prove that the expected region does indeed carry superconductivity. Furthermore,
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carrie
Objective: To conduct a replication study to investigate whether the 2945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. Methods: The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case-control sets of European ancestry (Spanish, French, Dutch, German, British, Swedish and North American
Excited states in the T-z = -1 nucleus V-44 have been observed for the first time. The states have been identified through recoil-gamma-gamma coincidences and comparison with analogue states in the mirror nucleus Sc-44. Mirror energy differences have been extracted and compared to state-of-the-art fp shell-model calculations which include charge symmetry breaking forces.
The aim of the present study is to cast some light on the realisation of sj- and tj-sounds (/ɧ/ and /ɕ/) in Estonian Swedish. These sounds are said not to occur in this variety of Swedish, or to have a different realisation as compared to Standard Swedish (Lagman, 1979). Our analysis, based on repetitions of elicited words produced by five elderly speakers of Estonian Swedish, shows that sj- and t
