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INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant
This paper studies whether central bank collateral frameworks play a stabilising role during large redemption shocks to investment funds. Using the “dash-for-cash” of 2020 as a case study, we find that funds with a higher share of ECB-eligible corporate bonds experienced lower redemption volumes, especially those with close affiliation to banks. We also find that asset managers followed a liquidat
As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress. © Springer Nature America, Inc. 2026.
Temperature variability and long-term warming are increasingly threatening agricultural sustainability in southern Rwanda, where smallholder farmers rely on climate-sensitive crops. However, comprehensive spatiotemporal assessments of temperature extremes and their impacts on agriculture remain limited. This study used daily minimum and maximum temperature data from 1983 to 2021 for Huye District,
Obesity’s metabolic heterogeneity is not fully captured by body mass index (BMI). Here we show that deep multi-omics phenotyping of 1,408 individuals defines a metabolome-informed obesity metric (metBMI) that captures adipose tissue-related dysfunction across organ systems. In an external cohort (n = 466), metBMI explained 52% of BMI variance and more accurately reflected adiposity than other omic
A soft magnetic core loss tester originally designed for sinusoidal flux excitation has been modified to enable multi-level PWM excitation. The setup is used to characterize an automotive-grade stator core under magnetic flux densities and excitation frequencies up to 1.4 T and 400 Hz respectively, as well as, switching frequencies between 4 and 16 kHz, with PWM voltage levels reaching up to seven
Background: Blood cultures (BCs) are key diagnostic elements for sepsis patients. Accurate preanalytical procedures are substantial, and results should be available as soon as possible to guide adequate antimicrobial treatment. This study aimed to evaluate BC collection practices and diagnostic capacity across European hospitals. Methods: This cross-sectional survey investigated BC diagnostics in
Efficient and clean production of electrical and mechanical energy for use in industry, transportation and propulsion is currently a concern. The transition from fossil fuels to biofuels involves challenges related to the fuel composition and combustion, as well as methods to increase engine fuel flexibility. One potentially useful tool under development is Plasma Assisted Combustion (PAC), where
Like many cities worldwide, Amsterdam has ambitious plans around sustainability transitions. The city has oriented towards an alternative economic development model called “Doughnut Economics” and has attempted to implement ideas from the work of economist Kate Raworth on the ground through a “Doughnut Strategy” and the Amsterdam Doughnut Coalition. This paper explores the evolution of Amsterdam's
Renewable diesel fuels may reduce greenhouse gas emissions and particulate matter compared to fossil diesel, but the toxicity of their combustion products remains unclear. This study assessed pulmonary effects of renewable diesel exhaust particles in female C57BL/6NTac mice after single intratracheal instillation (6, 18, or 54 µg/mouse). Particles were generated from renewable fuels (rapeseed meth
Background Advances in medical and surgical care have improved survival in patients with transposition of the great arteries (TGA), shifting focus toward quality of life (QoL). In this study we evaluate QoL in adults with TGA, including congenitally corrected TGA (ccTGA) and patients with dextro-TGA (d-TGA), by comparing patients with a systemic right ventricle (sRV) and systemic left ventricle (s
We report resonant inelastic x-ray scattering (RIXS) spectra of neon atoms interacting with intense x-ray pulses generated using an x-ray free-electron laser (XFEL). We find that an unexpected peak emerges near the Ka line of Ne, which does not coincide with any physical resonances of neon ions. We perform theoretical calculations based on a quantum-state-resolved rate-equation approach with x-ray
Precise synchronization of paleoclimate records is essential for inferring the dynamics and past evolution of the climate system. For the last glacial period, the time scales of ice cores from the Greenland and Antarctic ice sheets have been synchronized by the use of cosmogenic radionuclides, atmospheric gas concentrations, and traces of large volcanic eruptions. Here we identify the sulfate depo
Abstract – Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of na
Introduction: Turnover rates among health-care personnel are rising, which could jeopardise patient safety and the quality of care. One contributing factor to the high turnover is the prevalence of mental distress. Stress of conscience among healthcare personnel has been shown to affect them negatively, and feeling that they cannot provide the care their patients need increases their stress levels
Despite frequent use of conodonts as an archive for seawater 87Sr/86Sr, available diagenetic screening tools are inconsistent predictors of primary seawater 87Sr/86Sr preservation. Here, we attempt to isolate variables affecting the preservation of seawater 87Sr/86Sr in conodonts. We present new Middle–Late Ordovician (∼470–450 Ma) conodont 87Sr/86Sr from mid-paleolatitude (30–45°S) carbonate succ
Passivity arises from spontaneous formation of a thin protective passive film (oxide/hydroxide layer) on the metal surface, and the stability of passive film is of great importance for corrosion resistance. This study investigates the formation, stability, and transpassive dissolution of passive films on two Ni-based alloys, Alloy 625 and Alloy 59, in acidified NaCl solution, by combining in situ
Background: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries in relation to the timing of
Microplastics (MPs) are ubiquitous anthropogenic particles that accumulate in coastal zones, sediments, and the water column. The exposure of organisms to MPs in these habitats may depend on foraging strategies and landscape characteristics. This study compared MP contamination in the feces of waterbirds from two trophic groups: benthivores (American oystercatcher Haematopus palliatus; white-backe
