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The interactions of the bile salt sodium taurocholate (TC) in 50mM Trizma-HCl buffer and 150mM NaCl (pH 9) at 37 degrees C with membranes composed of sphingomyelin (SM) were studied by dynamic light scattering, cryogenic transmission electron microscopy (cryo-TEM) and turbidity measurements. Small unilamellar SM vesicles were prepared by extrusion. Below the CMC of TC, taurocholate addition leads
We review the basic principles of ultrafast charge delocalization phenomena in aqueous electrolytes following core-level photoionization and resonant core-level excitations, and describe how these processes can be probed using Auger electron spectroscopy. The use of the core-hole clock method to extract dynamical information from Auger spectra is described. By a number of examples we demonstrate h
The term ?reproductive, maternal, newborn, and child health (RMNCH)? describes an integrated continuum of health states which is central to Millennium Development Goals 4 and 5. While the burden of mortality and morbidity associated with RMNCH is well known, knowledge is still limited about the economic burden of RMNCH. Concrete evidence of cost of illness (COI) of RMNCH may help policy makers in
Patient reported outcomes (PROs) are important measures in rheumatoid arthritis (RA). A register of patients with RA from all rheumatology care providers in Malmö, Sweden, was established in 1997 and has been continually updated. This register includes virtually all the RA patients in the area. The aim of this study was to analyse PROs in surveys of this population conducted between 1997 and 2009,
Popular Abstract in Swedish Högt blodtryck (hypertoni) är en folksjukdom. Omkring 1,8 miljoner personer i Sverige, motsvarande 25 % av den vuxna befolkningen över 20 år, lider av hypertoni. I 90 % av fallen är orsaken okänd och klassificeras då som essentiell/primär hypertoni. Vid sekundär hypertoni finns det en eller flera bakomliggande orsaker till det höga blodtrycket, till exempel: förträngninArterial hypertension is a very common disorder. In most cases the cause is unknown and therefore classified as essential or primary hypertension. Primary aldosteronism (PA), characterized by an inappropriate aldosterone secretion, has traditionally been estimated to account for approximately 1 % of all hypertensive cases. By using the aldosterone to renin ratio (ARR) as a screening tool, the dete
Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key subsets of mRNAs that cooperate in distinct steps of PCa initiation and progression. Epidemiological ev
Background and purpose - The original Müller acetabular reinforcement ring (ARR) shows favorable medium-term results for acetabular reconstruction in total hip arthroplasty, where it is used when the acetabular bone stock is deficient. However, there are no data regarding long-term survival of the device. We therefore investigated long-term survival and analyzed radiological modes of failure. Pati
Background: Little is known about the prevalence of pulmonary tuberculosis (TB) in low income countries. We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding. Methods: Two cohorts were selected based on a previous HIV survey, but only 52.5
Background: To assess the annual consultation prevalence and new onset consultation rate for doctor-diagnosed shoulder pain conditions. Methods: We identified all residents in the southernmost county in Sweden who received a shoulder pain diagnosis during 2006 (ICD-10 code M75). In subjects who did not consult due to such disorders during 2004 and 2005, we estimated the new onset consultation rate
This thesis investigate if long-term exposure to traffic pollution is a risk factor for development of chronic respiratory disease and allergy in adults and children in southern Sweden (Scania). Information about health was obtained from surveys and health care registers. Traffic pollution exposure was estimated by traffic intensity and levels of NOx at residential addresses, which were obtained
About the crusade against the Cathars in Languedoc.
Abstract in Undetermined How intense do people expect their future emotional reactions to be? This should depend on the fit between the social perspective (near vs. distant) involved in the emotion and the emotion-eliciting event’s temporal distance. Temporal distance and social distance are interrelated (Trope & Liberman, 2010). We therefore argue that people should anticipate experiencing em
Charged jet production cross sections in p-Pb collisions at root s(NN) = 5.02 TeV measured with the ALICE detector at the LHC are presented. Using the anti-k(T) algorithm, jets have been reconstructed in the central rapidity region from charged particles with resolution parameters R = 0.2 and R = 0.4. The reconstructed jets have been corrected for detector effects and the underlying event backgrou
Group B Streptococcus (GBS) causes invasive infections in human newborns. We recently showed that the GBS beta-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes. Interestingly, neutrophils and monocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but s
The thermal physiology of most birds and mammals is characterised by considerable spatial and temporal variation in body temperature. Body temperature is, therefore, a key parameter in physiological, behavioural and ecological research. Temperature measurements on freely moving or free-ranging animals in the wild are challenging but can be undertaken using a range of techniques. Internal temperatu
