Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromeres (neocentromeres). Little is known about the origin and structure of these RGM chromosomes, including how they arise, their internal organization, and which s

TnBgl1A from the thermophile Thermotoga neapolitana is a dimeric beta-glucosidase that belongs to glycoside hydrolase family 1 (GH1), with hydrolytic activity through the retaining mechanism, and a broad substrate specificity acting on beta-1,4-, beta-1,3- and beta-1,6-linkages over a range of glyco-oligosaccharides. Three variants of the enzyme (TnBgl1A_E349G, TnBgl1A_E349A and TnBgl1A_E349S), mu

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover tr

Objective: This study evaluated changes in self-efficacy in non-physically active adolescent girls (13-19 years old) who participated in a six-month, empowerment-based exercise intervention programme (EIP). Design: The study used a pre- and post-test randomized group design and included one pre-and one posttest (at six months) and non-physically active adolescent girls (N = 110) were assigned to a

This paper deals with policy measures in the regional innovation system of Scania, Southern Sweden. Focus is on the innovation policy requirements of actors representing industries that draw on different knowledge bases. Previous studies have identified profound industry-specific differences concerning the organisation of knowledge sourcing between firms and other actors. In correspondence with th

Currently available research suggests that negative pressure wound therapy (NPWT) creates a moist wound healing environment, drains exudate, reduces tissue edema, contracts the wound edges, mechanically stimulates the wound bed, and influences blood perfusion at the wound edge, which may lead to angiogenesis and the formation of granulation tissue. Although no clear evidence is available that NPWT

We have analyzed the geochemistry and mineralogy of the five characteristic beds that constitute the Dababiya Quarry Member (DQM) recovered from the Dababiya Quarry Core located near the Global Stratotype Section and Point (GSSP) for the base of the Eocene. Well developed in Upper Egypt, these beds are known to record the isotopic and biotic signatures of the Paleocene/Eocene thermal maximum (PETM

The phonological trace of perceived words starts fading away in short-term memory after a few seconds. Spoken utterances are usually 2–3 s long, possibly to allow the listener to parse the words into coherent prosodic phrases while they still have a clear representation. Results from this brain potential study suggest that even during silent reading, words are organized into 2–3 s long ‘implicit’

Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanic

A novel pathlength enhancement approach has been applied in multimode diode laser correlation spectroscopy measurements of gas concentrations. Reference and sample gas cells made of porous polystyrene foam and alumina ceramic, respectively, were employed in proof-of-principle measurements of molecular oxygen. Equivalent pathlengths of 164 and 52 cm were obtained for the reference and sample cells

Attempts to engage critically with citizenship, both within critical human rights theory and within cosmopolitan and multicultural citizenship theory, often underline how the status of the citizen has ceased to be perceived as a privilege and is instead viewed in terms of universal access to political rights and political participation. The political man is thus constituted by his citizenship and

To describe a new model for in vitro assessment of novel vitreous substitute candidates.

We have found a new source of information about what lies beneath the Kalahari sands. The Kheis and Rehoboth Provinces of southern Africa were thought to be underlain by either an similar to 1800 Ma orogenic belt, or a northern branch of the similar to 1200 Ma Namaqua-Natal Province. Glacial diamictites of the Permocarboniferous Dwyka Group exposed at Rietfontein west of the Kalahari sands carry c

Our aim with this study was to develop a user-friendly method for pediatric sonographically guided lumbar punctures so that we can visualize intrathecal anatomy, confirm intrathecal injection at the time of injection, and, most importantly, avoid ionizing radiation to a child's already radiosensitive pelvis. Sonographically guided lumbar puncture was prospectively performed in children aged 7 week

Combined U-Pb, O and Hf isotope data in zircon allows discrimination between juvenile and reworked crust, and is therefore a useful tool for understanding formation and evolution of the continental crust. The crustal evolution of basement rocks in central North America (Laurentia) is poorly constrained, as it is almost entirely overlain by Palaeozoic cover. In order to improve our understanding of

Aim: Risk factors for development of peripheral arterial disease (PAD) are the same as for atherosclerotic coronary or precerebral disease, and patients with PAD have a high prevalence of concomitant atherosclerotic disease in coronary and precerebral arteries. However, these patients are still less likely to receive appropriate pharmacological secondary prevention than patients with coronary arte

Fatigue has been shown to be a consistent and common problem in Parkinson's disease (PD) in multiple countries and cultures. It is one of the most disabling of all symptoms, including motor dysfunction, and appears early, often predating the onset of motor symptoms. Several studies of the epidemiology of fatigue have been published, often using different scales, but few on treatment. The Movement

Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim

Objective To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Methods Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. Resu