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Direct gene transfer to the adult brain is dependent on vectors that transduce non-dividing cells, such as lentiviral vectors. Another aspect of the development of gene therapy to the brain is the need for cell-specific transgene expression. Expression from vesicular stomatitis virus G-protein (VSV-G) pseudotyped lentiviral vectors has been reported to be mainly neuron specific in the brain. We co
BACKGROUND: Statins reduce cardiovascular events and progression of carotid intima-media thickness (IMT). beta-Blockers are also known to reduce cardiovascular events, but less is known about their effects on carotid IMT. METHODS AND RESULTS: We conducted a randomized, double-blind, placebo-controlled, single-center trial to compare the effects of low-dose metoprolol CR/XL (25 mg once daily) and f
OBJECTIVE—To estimate the prevalence and severity of diabetic retinopathy (DR) 10 years after diagnosis in a nationwide population-based cohort study of young adult diabetic patients in Sweden. RESEARCH DESIGN AND METHODS—The Diabetes Incidence Study in Sweden (DISS) aims to register all incident cases of diabetes aged 15–34 years in Sweden. In 1987–1988, 806 cases were reported, and 627 (78%) of
The article discusses the process of the divergence of Swedish dialects in the Middle Ages and early modern time. Contrary to what is generally believed it is argued that the development is rather slow in the Middle Ages and more rapid afterwards until approximately 1800. Various demographic and other socio-historical factors are proposed as explanations.
The thesis has two aims. The first one is to contribute to the field of political and historical sociology through an understanding of the processes of state formation in a Third World country. The second aim is to describe and analyze the development of the Nicaraguan state from independence to 1990. In the first part of the dissertation theories of the nation-state and state formation are discus
Enzymes that require a redox-active amino acid for catalysis or function have emerged as a distinct class of proteins. For the tyrosine-based radical enzymes, we show that the spin-density distribution in the radical follows an odd alternate pattern that is invariant to within 10% across the class. General properties of the radical enzymes are summarized from which we conclude that their essential
Observation is made of rapidity-alignment of K+K- and (p) over barp pairs which results from their asymmetric orientation in rapidity, with respect to the direction from primary quark to antiquark. The K+K- and (p) over barp data are consistent with predictions from the fragmentation string model. However, the (p) over barp data strongly disagree with the conventional implementation of the cluster
In order to determine the total number of fibres and the extent to which the relative occurrence of different fibre types varies within m. vastus lateralis, 15 micrometers thick cross-sections of whole muscles were prepared. The total number of type 1 and type 2 fibres was determined in every 48th square millimetre of the section, and the results thus obtained were analysed using a computer progra
In this paper, we study and compare a number of subspace-based methods for determining the the number of sinusoids in noise. These are based on the subspace orthogonality and and shift-invariance properties that are known from the MUSIC (multiple signal classification) and ESPRIT frequency estimators. The method based on the orthogonality property has not previously appeared in the literature. We
Modelling the temperature dynamics of a district heating system is typically validated for a single pipe or a system with limited information about dynamic consumer behaviour. In the present work, time dependent consumer data from the Naestved district heating system was used to investigate the ability of modelling tools to represent the temperature profile distortion throughout an entire heating
Coronary artery disease (CAD) is a condition in which the blood supply to the myocardium is partially or completely blocked due to plaque build-up in the artery wall. Myocardial SPECT imaging is a commonly used technique to assess the blood flow to the myocardium and the function of the heart. The interpretation of the images can be difficult and subjective. Several automatic myocardial SPECT quan
We obtained a long-time-storage mechanism for spectral features in thulium ions doped into YAG by applying a magnetic field that splits the electronic ground state. We show experimentally that the storage time can be more than 30 s, which is 3 orders of magnitude longer than that of the metastable state that normally is used for information storage in this material. Level splitting and storage lif
Our voices and speech behaviour give cues to the listener as to our identity. These cues make it possible for the listener to recognise a voice without seeing the speaker. A professional impersonator has to identify the salient and characteristic features of the target voice in order to succeed. The present phonetic study of a Swedish professional impersonator and one of his voice imitations compa
Abstract is not available
The surface properties of several modified stainless steel samples were characterized according to their chemical composition, roughness, topography and wettability. The modifications tested were SiF3+ and MoS22+ ion implantation; diamond-like carbon (DLC) sputtering: DLC. DLC-Si-O and SiOx, plasma enhanced chemical vapor deposition (PECVD); autocatalytic Ni-P-PTFE and silica coating. X-ray photoe
