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2593Background: PD-1 blockade has demonstrated positive anti-tumor activity across multiple tumor types. While the anti-tumoral response can be substantial and even curative, response rates remain low in many cancer types. Long-lasting responses are only observed in a minority of patients, and additional immunotherapeutic alternatives remain limited for patients who fail to respond or initially re
2641Background: BI-1808 is an IgG1 mAb that target TNFR2 by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8+ T cells. Upon co-administration of murine surrogate antibodies targeting TNFR2 and anti-PD-1 to immunocompetent tumor-bearing mice with partial sensitivity to checkpoint blockade, complete cures were observ
Background: Selected patients with advanced germ cell tumors have a poor prognosis. These include patients with brain, bone or liver metastases, very elevated tumor markers or primary mediastinal tumor. High-dose chemotherapy (HDCT) with autologous stem cell support is recommended in the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) guidelines in selected poor risk patients with poor r
BACKGROUND In the United States, Black men are at highest risk for being diagnosed with and dying from prostate cancer. Given this disparity, we examined relevant data to establish clinical prostate-specific antigen (PSA) screening guidelines for Black men in the United States. METHODS A comprehensive literature search identified 1848 unique publications for screening. Of those screened, 287 studi
Walking is a primary mode of transport in urban Africa, yet it remains unsafe, challenging, and unpleasant. In contrast, several European countries have implemented systematic policies to promote walking through Safe System principles. This study compares pedestrian safety in three African countries (Tanzania, Ghana, Zambia), with three European countries with excellence in road safety and Safe Sy
A set of nineteen C-galactopyranosyl ligands, which included constrained compounds based on a bicyclic trans-decalin type system. were synthesized via click chemistry from 2-(β-d-C-galactopyranosyl) ethylene azide intermediates. The compounds were evaluated for binding to various galectins and the most promising inhibitor from the series was a constrained 3-O-benzylated galactopyranose derivative,
Background: The prevalence of mental health problems is increasing, placing growing pressure on mental healthservices to provide care that is meaningful, accessible, and supportive for those who require it. However, currentpractices often do not fully meet individuals’ needs for person-centred, recovery-oriented, and integrated care andsupport. As these care and support models are being introduced
Context. The discovery and characterization of mini-Neptunes hold a potentially crucial impact on planetary formation and evolution theories. Estimating their orbital parameters and atmospheric properties would provide valuable hints to improve formation and atmospheric models. Aims. We present the discovery of two mini-Neptunes near a 2:1 orbital resonance configuration orbiting the K0 star TOI-1
A search is performed for dark matter particles produced in association with a resonantly produced pair of (Formula presented)-quarks with (Formula presented) using (Formula presented) of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. This signature is expected in extensions of the standard model predicting the production of dark matter par
INTRODUCTION: Placental transfusion at caesarean sections (CS) is affected by different factors, such as cord clamping (CC) time and the cardiopulmonary transition of the infant. Measuring residual placental blood volume (RPBV) is one method to assess the magnitude of placental transfusion. The aim of this study was to evaluate the association between CC time and RPBV in elective and emergency CS,
We estimate the effects of exposure to income and wealth inequality during adolescence on long-term educational and labor market outcomes. Using detailed Swedish register data covering all students completing compulsory education between 1989 and 2013, we construct measures of inequality among students’ school-cohort peers and exploit variation between cohorts within schools to identify causal eff
We examine whether culturally transmitted time and risk preferences help explain differences in preventive health care uptake. We combine individual-level survey data from 27 European countries with country-level preference measures from the Global Preferences Survey. To isolate cultural influences from institutional and economic confounders, we focus on second-generation immigrants, who were born
Reconfigurable scan networks (RSNs) provide efficient and flexible access to on-chip logic, such as instruments for test and diagnostics, throughout a semiconductor’s lifetime. Test instruments are powerful, as they provide high controllability and observability. The availability of a high number of test instruments, as well as the standardized and easy access, makes RSNs a valuable target for an
The high-luminosity phase of LHC operations (HL-LHC), will feature a large increase in simultaneous proton-proton interactions per bunch crossing up to 200, compared with a typical leveling target of 64 in Run 3. Such an increase will create a very challenging environment in which to perform charged particle trajectory reconstruction, a task crucial for the success of the ATLAS physics program, an
Objective: Failure to rescue (FTR), defined as mortality due to failure in responding to in-hospital complications, is an important quality indicator. This study aimed to assess incidence and predictors for FTR among centers performing fenestrated-branched endovascular aortic repair (FB-EVAR) of thoracoabdominal aortic aneurysms (TAAA). Methods: Consecutive patients treated by FB-EVAR for TAAAs be
Universities support their teaching staff to develop contemporary teaching compe-tencies, yet institutional priorities may not align with those of staff. This study ex-amined open texts from 863 teaching staff from 16 departments at a research-inten-sive university to discover self-identified teaching competency needs. Five universal priorities were identified (student engagement, course developme
A search for the production of three Higgs bosons ((Formula presented)) in the (Formula presented) final state is presented. The search uses (Formula presented) of proton-proton collision data at (Formula presented) collected with the ATLAS detector at the Large Hadron Collider. The analysis targets both nonresonant and resonant production of (Formula presented). The resonant interpretations prima
We provide new evidence that short-run temperature shocks affect unemployment dynamics. Linking daily weather data with three decades of Current Population Survey microdata, we show that cold, but not hot, temperatures significantly increase unemployment risk. This effect is concentrated in climate-exposed industries and driven by both increased job separations and longer unemployment durations. S
