Ett nytt sätt att skapa modellhjärnor i labbet När man bedriver forskning på celler i ett labb, så är det viktigt att cellerna faktiskt beter sig som de gör i kroppen. Labbmiljön för celler, är däremot oftast ganska långt ifrån den miljön de normalt upplever i din kropp, vilket har gett upphov till idén om 3-dimenstionella cellodlingar. 3D-Odlingar är idag förhållandevis utbrett, med ett brett ar

The baker’s yeast, Saccharomyces cerevisiae (S. cerevisiae) was studied and genetically engineered. This was to enhance the transamination step of the biochemical reaction cascade towards the production of capsaicin. Inherent reductases were identified and twelve of them knocked out via homologous recombination. Using the CRISPR/Cas9 technology, the Green Fluorescence Protein (GFP) gene was introd

Jordbruksmarken i Sverige är en stor anledning till varför en stor mängd kväve och fosfor transporteras till vattendrag, sjöar och hav. Näringstransporten medför konsekvenser för miljön då växtorganismers förutsättningar förändras och övergödning sker. Våtmarker är ett naturligt inslag i miljön som har näringsrenande egenskaper gällande kväve och fosfor. Under det senaste seklet har uppemot en fjäThe agricultural land in Sweden is a major reason why a large amount of nitrogen and phosphorus is transported to rivers, lakes and the sea. Nutrient transport has consequences for the environment as the conditions for plant organisms change and eutrophication takes place. Wetlands are a natural part of the environment that have nutrient removing properties regarding nitrogen and phosphorus. Durin

Title: Critical Supply Chain Factors for Scaling a Startup -- A Case Study in the Industry of Semiconductors Author: Pontus Landgren Supervisors: Bertil Nilsson, Lund University, Faculty of Engineering & Lennart Moberg, Acconeer AB Background: A well implemented supply chain strategy aligned with the company's overall strategy is a prerequisite in order to successfully scale a startup.

Obtaining DNA sequences is a time-consuming task, which typically requires one or several days for completion. One way of reducing analysis times is to be satisfied with long-range sequence patterns on the order of thousands of base pairs. DNA barcoding is a DNA-characterising technique that works according to this principle. It does so by using fluorescence microscopy to visualise long-range sequ

To optimize the weights in an artificial neural network most methods rely gradients, which are not always obtainable or desirable. Evolutionary algorithms are instead based on Darwinian evolution where no derivative is needed. These algorithms have a set of strategy parameters that can be dynamically updated during the search to increase performance. Two ways of updating the parameters are the so

Purpose: The purpose of this essay is to examine the different relationships between the auditor and its clients and how this relationships affects the quality of the audit. Theoretical perspectives: The theoretical framework is based on a description of relationships based on Duff (2014) and a description of audit quality which is partly based on Tepalagul & Lin (2015) and Wright & Wrigh

Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel

I en jämförelse mellan det skriftliga och det arkeologiska materialet framträder en bild av medeltida tegelbruk i allmänhet och det medeltida tegelbruket vid S:t Mikael i synnerhet. Arkeologiskt iakttagbara anläggningar vid ett medeltida tegelbruk, förutom en tegelugn är följande; lertag i form av gropar eller stora gravar (eventuellt vattenfyllda), vallar efter leran som lagts till vintring, gropWhen, why and how the brick-making tradition started in the Nordic countries is well known. However, research on the spatiality and layout of the the production of bricks in medieval times is lacking. What archaeologically observable sites, apart from a kiln, were part of a medieval brickyard and how were they organized? In a comparison between written material on brick production and archaeologic

We unify literature on licensing in the pharmaceutical industry and empirically verify pre-established and identify new determinants of value creation and appropriation based on a contemporary data set of licensing deals made between 2015 and 2020. We observe positive returns for licensor and licensee. A return differential indicates value appropriation by the licensor due to scarcity. A positive

Respiratory tract infections (RTIs) are a major global health concern. Several studies indicate that most respiratory bacterial pathogens are capable of asymptomatic colonization and find their primary ecological niche within the nasopharynx of healthy individuals as harmless commensals that form biofilms. However, in response to external factors, such as concomitant virus infections, colonizing b

Birds endure ecological constraints during winter in temperate regions where critical resources vary significantly between urban and rural sites, influencing survival rate. Warmer temperatures and artificial food sources have led to an increase in urban avian winter abundance whereas birds in colder, rural ecosystems are more reliant on scarce natural food sources but subject to less human disturb

Migration is an adaptation for birds to exploit the resources that change temporally and spatially. The recent development of miniature light level geolocators has revealed this previously poorly known aspect of birds. From light intensity data together with time recorded by geolocators, we can infer the positions of the birds, i.e. latitudes and longitudes, using a threshold method or a curve-fit

Studiens syfte var att uppnå en ökad förståelse för hur beslutsfattande personal med erfarenhet från Migrationsverkets asylenhet, upplever att de förhåller sig till, påverkas av- samt hanterar arbetsrelaterade emotioner i förhållande till asylenhetens emotionsregim. Syftet var därmed att genom kvalitativa intervjuer undersöka hur personal förhåller sig till en sådan emotionsregim vilken reglerar a

Migration to wintering grounds is a process that a large proportion of songbirds perform every year. It has been suggested that there are differences in the migration performance between adults and juveniles due to the experience the former have over the latter, after having flown this journey before. The aim of this study was to analyse age differences regarding activity, energy deposits and depa

Dengue is just regular flu but also kills many people all around the world. We all happen to know that dengue viruses have been on the march for the last 100 years. During the late 20th century, it became a serious threat to mankind. Our scientists have been putting their utmost efforts to save people from dengue infections. They have come up with a number of vaccinations and mosquito repellent so

This study aims to gain a deeper understanding of how individuals, in an organizational context, experience the process of unlearning in relation to routines and how these individuals might be influenced in their unlearning process.

Styvhetsförändringar i bröstvävnad är ofta kopplade till en patologisk förändring. Vissa cancertyper som infiltererande duktalt carcinom kan vara åtta gånger så styv som fettvävnaden runt omkring. Genom att komprimera bröstet och mäta trycket på bröstets yta har man identifierat att det blir en lokal förhöjning i tryck där det finns en tumör. Med hjälp av den här typen av mekanisk avbildning av brA change in stiffness of breast tissue is often connected to a pathological change. Some types of breast cancer such as infiltrating ductal carcinoma can be up to eight times stiffer than fat tissue. It has been found that during compression of the breast there will be a local area of relatively high stress at the breast surface at the location of a tumour. This type of mechanical imaging of the b

Optimization is the study of finding the best solution for a problem. The applications of this field ranges from finding the best routes for travelling to finding the ground state of physical systems. This thesis looks at gradient based and gradient-less optimization algorithms which are applied to two problems: the linear least square and the position of a system of springs. The algorithms used a