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Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),

How well patient perceived outcome reflects clinical measurements after arthroscopic lysis and lavage of the temporomandibular joint (TMJ) is not fully understood.The purpose of this study was to detect any correlation between patient reported outcome measures (PROM) and clinical follow-up measurements.Patients with internal derangement of the TMJ treated with arthroscopic lysis and lavage 2014–20

Purpose: Direct percutaneous access to the carotid artery (diPerCa) during endovascular aortic arch repair (EVAAR) can potentially present a minimally invasive access with lesser local adverse events. Techniques: A retrospective review of consecutive EVAAR between January 2018 and January 2024, in a tertiary referral center, was performed to identify cases, in which diPerCa was used. Patients who

This article further theorises and develops the notion of a threat of abandonment while trying to elucidate the applicability and usefulness of this concept in the case of Ukraine in its fight against Russia since 2014. If Ukraine perceives the European Union (EU) as weakened by multiple crises, it may translate this image into a scenario of less attention to Ukraine and its problems, and – ultima

Aims/hypothesis: A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is needed to guide risk stratification and prevention. We investigated the risk of infection in subgroups of individuals with type 2 diabetes according to indices of insulin sensitivity and beta cell function. Methods: We classified 7265 individuals with recently diag

This article addresses the issue of how Social Science and Humanities (SSH) researchers frame and argue relevance, where there are no explicit expectations to do so. It uses research project reports submitted to a Swedish research council, to distil and further analyze ‘relevance expressions’. These expressions illustrate some methodological differences along the lines of the long-standing distinc

Aim: Public health nurses working in high schools have few set tasks, and there is limited research available on their flexible role. Therefore, the aim of the study was to describe public health nurses’ perspectives on their role when working in Norwegian high schools. Design: A qualitative descriptive design, with an inductive approach. Sample: Eight public health nurses with at least 1-year of

Nonoverlapping domain decomposition methods have been utilized for a long time to solve linear and nonlinear elliptic problems, and more recently, parabolic problems. Despite this, there is no convergence theory for nonlinear elliptic and parabolic equations on general Lipschitz domains in Rd, d ≥ 2. We therefore develop a Steklov–Poincaré theory for nonlinear elliptic and parabolic problems and s

Trust is an important aspect of learning. However, there is little published research on how students perceive its value. In this article, we report on engineering students’ perceptions of the role of trust in their learning and their experiences of what teachers do in their courses that builds trust. Nine students participated in semi-structured interviews and 477 student replies to a survey sent

Background: Cerebrovascular accident (CVA) is an outdated termfor describing stroke as it implies stroke is an accident.We conducted an integrative review to examine the use of CVA in terms of (1) frequency in major medical journals over time; (2) associated publication characteristics (e.g., number of authors, senior author country, topic); and (3) frequency in medical records. Methods: We search

Studies addressing patients’ experiences of person-centered care (PCC) in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce; hence, this study aimed to explore patients’ experiences of PCC, and its associations with individual characteristics and health-related quality of life, in the context of allogeneic stem cell transplantation. It is a cross-sectional su

This paper presents a general level set framework for modelling diffusive solid-state phase transformation processes in binary systems comprising several grains and phases. Notably, it is demonstrated how the Voronoi implicit interface method (VIIM) can be used to simulate microstructure evolution in polycrystals driven by diffusion. The key advantage of VIIM is that a single level set function ca

The purpose of the essay is to explore the possibility of using some insights of the Russian philosopher of the dialogic word and literary scholar Mikhail Bakhtin in supervision, from an existential perspective. The essay ends with a case. Translations from Swedish and French are mine, when otherwise not stated.The purpose of the essay is to explore the possibility of using some insights of the Russian philosopher of the dialogic word and literary scholar Mikhail Bakhtin in supervision, from an existential perspective. The essay ends with a case.

Review of the book The Birth of Computer Vision by James E. Dobson (2023) Minneapolis (MN), University of Minnesota Press, viii-205 pp.

The Swedish inventor and scientist Christopher Polhem (1661-1751) has been called the Daedalus of the North. This article concerns the picture of Polhem through the ages, what has been written concerning him, and about the still surprisingly modest research on him. First gives a short introduction to Polhem. His own life story, put forward by himself, has had an immense influence on the following

How do we relate to monuments and statues in public spaces? And how do our perceptions shift when history confronts us with new insights?In the wake of the Black Lives Matter movement in 2020, many monuments and statues across the world became the focal point of intense debate. Some were torn down, others covered up, and others were re-examined in light of not only colonial and racial oppression,