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Non-Canonical Functions of the Gamma-Tubulin Meshwork in the Regulation of the Nuclear Architecture
The nuclear architecture describes the organization of the various compartments in the nucleus of eukaryotic cells, where a plethora of processes such as nucleocytoplasmic transport, gene expression, and assembly of ribosomal subunits occur in a dynamic manner. During the different phases of the cell cycle, in post-mitotic cells and after oncogenic transformation, rearrangements of the nuclear arcThe nuclear architecture describes the organization of the various compartments in the nucleus of eukaryotic cells, where a plethora of processes such as nucleocytoplasmic transport, gene expression, and assembly of ribosomal subunits occur in a dynamic manner. During the different phases of the cell cycle, in post-mitotic cells and after oncogenic transformation, rearrangements of the nuclear arc
X-ray forward diffraction wave-front propagation in Si and C single crystals : Simulations and experiments
The emergence of new high brilliance and high coherence facilities such as X-ray Free Electron Lasers (XFELs) and 4th generation synchrotrons open a new era in X-ray optics. Dynamical diffraction effects before disregarded are starting to play a role in the beam control of large scale facilities. In the case of XFEL facilities the temporal characteristics of the dynamical diffraction by thin perfe
Urinary tract infections in primary care. Antimicrobial resistance, treatment and outcome.
Effects of ambient methanol on pollutants formation in dual-fuel spray combustion at varying ambient temperatures : A large-eddy simulation
Large-eddy simulation with a finite-rate chemistry model is carried out to investigate the formation of soot and nitrogen oxides (NOx) in the dual-fuel spray combustion. Liquid n-heptane is injected into a constant volume chamber, filled with a premixed methanol–air mixture with an equivalence ratio (ϕm) of 0.3. Three dual-fuel cases are simulated under initial temperatures of 900, 950 and 1000 K.
Methyl-3-hexenoate combustion chemistry : Experimental study and numerical kinetic simulation
This work represents a detailed investigation of combustion and oxidation of methyl-3-hexenoate (CAS Number 2396-78-3), including experimental studies of combustion and oxidation characteristics, quantum chemistry calculations and kinetic model refinement. Following experiments have been carried out: Speciation measurements during oxidation in a jet-stirred reactor at 1 atm; chemical speciation me
The I-Rule of Law in the Making: a Constitutional Perspective on the GDPR
The translation of creativity into the language of the city
A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity : results from a large European cohort
Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proport
Purshasing as an ongoing process: An explorationes of consumers practices in retail store settings
Diagnosis ofirritable bowel syndrome would be better made by gastroenterologists than primary care physicians
Irritable bowel syndrome (IBS) is a common disease, and constitutes a large portion of patients admitted to gastroenterology units. We wanted to examine whether there is a need for patients with suspected IBS to have a thorough examination by a gastroenterologist to establish the diagnosis, or whether other specialist or subspecialist physicians could better or equally identify the problems. From
Data Consistency of the Burning Velocity Measurements Using the Heat Flux Method: Syngas Flames
This work is aimed at presenting a comparison and detailed analysis of the existing experimental data of laminar burning velocities obtained for syngas flames using the heat flux method. The consistency of these data is essential in the development, validation, and optimization of combustion mechanisms. The core of the approach is the evaluation of any variability or inconsistency among the data o
Small bowel enteroclysis with magnetic resonance imaging and computed tomography in patients with failed and uncertain passage of a patency capsule
Background: Video capsule enteroscopy (VCE) has revolutionized small bowel imaging, enabling visual examination of the mucosa of the entire small bowel, while MR enteroclysis (MRE) and CT enteroclysis (CTE) have largely replaced conventional barium enteroclysis. A new indication for MRE and CTE is the clinical suspicion of small bowel strictures, as indicated by delayed or non-delivery of a test c
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Dynamics of critical fluctuations : Theory – phenomenology – heavy-ion collisions
This report summarizes the presentations and discussions during the Rapid Reaction Task Force “Dynamics of critical fluctuations: Theory – phenomenology – heavy-ion collisions”, which was organized by the ExtreMe Matter Institute EMMI and held at GSI, Darmstadt, Germany in April 2019. We address the current understanding of the dynamics of critical fluctuations in QCD and their measurement in heav
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Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt
The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clou
Social class and fertility: A Long-run analysis of Southern Sweden, 1922–2015
This paper examines social class differences in fertility, using longitudinal micro-level data for a regionalsample in Sweden, 1922–2015. Using discrete-time event history models, we estimated the associationbetween social class and parity-specific duration to next birth, adjusting for household income in separatemodels. Social class was associated with fertility quite independently from income an
Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice
apolipoproteinM(apoM)mayserveaprotectiverole inthedevelopmentofinflammation.Nuclearfactor‑κB(nF-κB) and its downstream factors (including a number of inflammatory cytokines and adhesion molecules) are essential for the regulation of inflammatory processes. In the present study, the importance of apoM in lipopolysaccharide (LPS)‑induced acute inflammation and its potential underlying mechanisms, we