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Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality

BACKGROUND: Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and for this reason, we analysed prospectively collected admission blood samples from adult ICU patients at four Swedish hospitals. Blood samples were stored in a biobank for later ba

Dissociative Adsorption of CO2 on Copper: The Role of Steps

CO2 chemistry has received significant interest in recent time, due to the greenhouse effects of CO2 emissions and the resulting climate change. CO2 reduction reactions, such as methanol synthesis and reverse water-gas shift, is providing a route for recycling of CO2 and thus limiting the CO2 emissions. These reactions are commonly performed over Cu-based catalysts, making the interaction of CO2 a

Probing proton halo effects in the 8B+64Zn collision around the Coulomb barrier

Proton halo effects in the 8B+64Zn reaction at an energy around 1.5 times the Coulomb barrier have been studied at HIE-ISOLDE CERN using, for the first time, the only existing postaccelerated 8B beam. This, together with the use of a high granularity and large solid angle detection system, allowed for a careful mapping of the elastic angular distribution, especially in the Coulomb-nuclear interfer

Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany

Background: The contact allergy prevalences in patch-tested patients are usually higher than those in the population, owing to morbidity-driven selection. Objectives: To examine the differences between two samples, one from the population, one from the patch test clinic, in one area of Germany (Jena, Thuringia). Methods: Between August 2008 and October 2011, a total of 519 participants of the popu

Dynamics of Selected Biomarkers in Cerebrospinal Fluid During Complex Endovascular Aortic Repair – A Pilot Study

Introduction: Ischemic spinal cord injury (SCI) is a serious complication of complex aortic repair. Prophylactic cerebrospinal fluid (CSF) drainage, used to decrease lumbar cerebrospinal fluid (CSF) pressure, enables monitoring of CSF biomarkers that may aid in detecting impending SCI. We hypothesized that biomarkers, previously evaluated in traumatic SCI and brain injury, would be altered in CSF

Ventricular-arterial coupling : definition, pathophysiology and therapeutic targets in cardiovascular disease

Introduction: The heart and arterial system are equally affected by arteriosclerosis/atherosclerosis. There is a constant interaction between the left ventricular (LV) function and the arterial system, termed ventricular-arterial coupling (VAC), which reflects the global cardiovascular efficiency. VAC is traditionally assessed by echocardiography as the ratio of effective arterial elastance (Ea) o

Sharp asymptotic estimates for a class of Littlewood-Paley operators

It is well-known that Littlewood-Paley operators formed with respect to lacunary sets of finite order are bounded on Lp(ℝ) for all 1 < p < ∞. In this note it is shown that 'Equation Presented' where SIE2 denotes the classical Littlewood-Paley operator formed with respect to the second order lacunary set E2 = {±(2k -2l) : k, l ∈ ℤ with k > l}. Variants in the periodic setting and for certain lacuna

Risk of incident fractures in individuals hospitalised due to unexplained syncope and orthostatic hypotension

Background Impaired orthostatic blood pressure response and syncope confer a high risk of falls and trauma. The relationship between a history of unexplained syncope and orthostatic hypotension (OH) with subsequent fractures, however, has not been thoroughly examined. In this study, we aimed to investigate the relationship between previous hospital admissions due to unexplained syncope and OH and

Evolution of lignin decomposition systems in fungi

Lignin represents the second most abundant biopolymer of the plant cell wall. Among microorganisms, fungi are the most efficient lignin decomposers. The discovery of ligninolysis by fungi could have altered the ancient carbon cycle at the global scale and it is still one of the processes that determine carbon sequestration and soil formation. Understanding the evolution of ligninolytic systems rep

Variants in BANK1 are associated with lupus nephritis of European ancestry

The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal biopsies were available from 396 patients. The discovery cohort (Sweden, n = 1091) and replication cohort 1 (US, n = 962) were genotyped on the Immunochip and replication cohort 2 (Denmark/Norway, n = 833) on a custom array. Pati

Metabolic factors and the risk of Dupuytren’s disease : data from 30,000 individuals followed for over 20 years

Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer S