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Traumatic brain injury and stroke often result in contralateral sensorimotor deficits, including asymmetric posture. While these lateralized effects are classically attributed to neural tract disruption, recent evidence supports the existence of a complementary humoral pathway. Our previous work demonstrated that the neurohormone Arg-vasopressin (AVP) mediates right hindlimb responses to left-side
Studying the full universe of nearly 390,000 French patents filed between 1791 and 1900, I show that the nineteenth-century gender patenting gap arose less at the patent office than through unequal access to practical knowledge, collaborators, and time across the life course. I identify 4,165 women inventors using gender-specific honorifics, classify patents with machine learning, reconstruct the
PurposeThis study aims to assess the diffusion and integration of Circular Economy (CE) knowledge across academic disciplines, by examining how CE concepts spread within mainstream academic and disciplinary discourses.Design/Methodology/ApproachCE is conceptualized as a knowledge object, distinguishing between mainstream academic discourse (MAD) and mainstream disciplinary discourse (MDD). The res
Background: Adolescents are increasingly using classical psychedelics, yet little is known about how psychedelics use is related to their mental health. Emerging evidence suggests that adolescents may be more vulnerable to adverse outcomes in relation to psychedelic use compared to adults. This descriptive and exploratory study examined differences between adolescents and adults in reported psyche
The demand for safe and durable modified-wood products is increasing in the construction sector. In this work, the in situ wet-chemistry synthesis of a glassy MgO/Na2O–SiO2 solid in Scots pine (Pinus sylvestris L.) sapwood via a two-stage impregnation process using an industrial timber-impregnation autoclave is reported. Magnesium sulphate heptahydrate (MgSO4·7H2O), a historic fire retardant, and
Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx, a composite outcome that includes SevEx and acute worsening events (AWEs) (evaluated from e-diary entries using deterioration in peak expiratory flow (PEF), reliever medication use and worsenin
BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)
The purpose was to study the prognostic and predictive roles of DNA protein kinase catalytic subunit (DNA-PKcs), Ku70/80 and p53 for the effect of radiotherapy in breast cancer patients. Protein expressions of Ku70/80, DNA-PKcs and p53 were examined using immunohistochemistry in tumours from 224 breast cancer patients, who were randomised to receive post-operative radiotherapy or adjuvant chemothe
Purpose. Continuous minor steps of improvement in the management of breast cancer have resulted in decreased mortality rates during the last decades. The aim of this study was to compare the clinical outcome of patients with stage I breast cancer diagnosed during two time periods that differed with respect to adjuvant systemic therapy. Material and methods. The studied population consisted of all
Cyclin E and the retinoblastoma protein (Rb) are both important regulators of the G1 phase in the cell cycle. Overexpression of cyclin E and lost expression of Rb has previously been observed in breast tumours at frequencies of 10-50% and 20-30%, respectively. We explored the prognostic role of cyclin E and Rb in breast cancer patients randomised for tamoxifen (TAM), CMF (cyclophosphamide, metotre
In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the
BACKGROUND AND PURPOSE: The breast cancer susceptibility genes BRCA1 and BRCA2 interact with Rad51, one of the central components in the homologous recombination repair pathway. This study evaluates the prognostic and predictive role of BRCA1, BRCA2 and Rad51, individually and as a complex, in breast cancer.MATERIALS AND METHODS: Expression of BRCA1, BRCA2 and Rad51 was investigated using immunohi
Female-producing parthenogenesis is widespread in stick insects. It ranges from rare in sexual species to facultative or obligate, the latter sometimes in hybrids. This review synthesizes current knowledge on its origins, mechanisms, and evolutionary consequences, highlighting the distinction between hybrid and intra-specific origins. Hybrid-derived parthenogens are rare, obligate, frequently poly
Recent studies show how patterns and trends in social mobility look substantially different when both parents are considered rather than one. Using Swedish census and register data covering cohorts born 1865–1985 and their parents, I describe social mobility among both male-breadwinner and dual-earner family types, each reflecting a work-life context common globally today. This rich longitudinal d
Purpose: To investigate the expression and predictive role of the Mre11/Rad50/Nbs1 (MRN) complex and the ataxia-telangiectasia mutated protein (ATM) for the outcome of radiotherapy in breast cancer patients. Methods and Materials: The protein expression of ATM and the DNA repair proteins in the MRN complex were investigated using immunohistochemistry in tumors from 224 women with early breast canc
Background: Adjuvant therapy of breast cancer patients reduces the risk of recurrence and mortality, although, a substantial proportion of patients acquire resistance and relapse in the disease. Predictors of therapeutic response are therefore important to avoid both therapy resistance and the side effects of inefficient regimes. The p53 protein is a key determinant to induce either growth arrest
Understanding the synergistic impacts of climate change and human activities on runoff and sediment dynamics is crucial for sustainable watershed management in the Yellow River Basin. This study examined hydrological variations in the Helong section of the Chinese Loess Plateau from 1980 to 2020. The Mann?Kendall and Pettitt tests were used to detect trends and abrupt changes in precipitation, run
