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Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle.

Rho-associated kinases are involved in regulation of actin–myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells. By influencing the contraction of the intraendothelial filaments, Rho kinases may affect the size of the interendothelial gaps and thereby influence microvascular permeability. The aim of the study was therefore to investigate w

An experimental study of gastric stump carcinoma in Wistar rats

The risk of gastric stump carcinoma is increased 15-20 years after gastric resection for benign disease. Reflux of duodenal juice, bacterial overgrowth and formation of N-nitroso compounds are possible etiological factors. There is a geographical variation in the incidence of gastric cancer, possibly explained by differences in food intake. Experimentally it is possible to induce gastric stump car

Do sex hormones influence features of the metabolic syndrome in middle-aged women? A population-based study of Swedish women: The Women's Health in the Lund Area (WHILA) Study.

Objective: To outline perceived associations between various sex hormones and risk markers for cardiovascular disease in middle-aged women, with an emphasis on features of the metabolic syndrome (MS). Design: Cross-sectional analysis. Setting: Women's Health in the Lund Area Study. Patient(s): Population-based cohort. Intervention(s): A generic questionnaire, physical examinations, and laboratory

Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.

OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmo

Ab initio wavelengths and oscillator strengths for Cl X

Using the configuration interaction technique, the energy spectra of 2s(2)2p(4), 2s2p(5), 2s(2)2p(3)3s, 2s(2)2p(3)3d, configurations of oxygen-like chlorine Cl X have been calculated. The obtained data are used for the evaluation of wavelengths and oscillator strengths of all possible one-electron and two-electron 2s(2)2P(3)3p-2s2p(5) electric dipole transitions. The calculated results are compare

Use of (18)O water and ESI-MS detection in subsite characterisation and investigation of the hydrolytic action of an endoglucanase.

We present a novel method for investigating subsite-substrate interactions of glycoside hydrolases and the determination of the oligosaccharide cleavage point based on the analysis of the hydrolysis products produced in the presence of (18)O-labelled water. Conventional techniques for such determination of the hydrolysis pattern call for the chemical modification of the substrate, whereas the meth

Interactions of particles, adjectival resultatives and benefactive double object constructions in Norwegian

In this paper, I take a closer look at a set of observations concerning word order and co-occurrence restrictions on verb-particle constructions, berefactive double object constructions and resultative constructions in Norwegian. While a particle can co-occur with both a beneficiary DP and a resultative AP, beneficiary DPs and resultatives cannot co-occur at all. I give an analysis in terms of the

Traveling wave solutions of the Camassa-Holm equation

All weak traveling wave solutions of the Camassa-Holm equation are classified. We show that, in addition to smooth solutions, there are a multitude of traveling waves with singularities: peakons, cuspons, stumpons, and composite waves.

Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition

Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increa

Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia

Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ hybridization experiments show that DAPK mRNA expression is up-regulated in brain following a global ischemic insult and down-regulated in ischemic tissues after focal ischemia. DAPK is inactive in normal brain tissues, where it is found in its phosp

Two different approaches to model evolving directional properties at finite deformations

Two different approaches to modeling evolving anisotropic material behavior are investigated. The first approach models the evolution of the directionally dependent properties of the material in terms of evolution laws for the director vectors. In the second approach the evolution law for the plastic velocity gradient is enhanced by additional terms. It is shown that both approaches lead to an evo

The general Leigh-Strassler deformation and integrability

The success of the identification of the planar dilatation operator of N = 4 SYM with an integrable spin chain Hamiltonian has raised the question if this also is valid for a deformed theory. Several deformations of SYM have recently been under investigation in this context. In this work we consider the general Leigh-Strassler deformation. For the generic case the S-matrix techniques cannot be use

A Study on the Outcome of Percutaneous Transluminal Renal Angioplasty in Patients with Renal Failure.

Background: The indications for percutaneous transluminal renal angioplasty (PTRA) in renovascular disease, as well as its benefits, remain a matter of debate. The aim of this study was to evaluate the outcome of angioplasty and to identify risk factors associated with less successful outcomes in patients with atheromatous renal artery stenosis and renal failure of varying degrees. Methods: The re

Estimates of the prevalence and number of Fibromyalgia syndrome patients and their alpha-1 antitrypsin phenotypic distribution in ten countries

Objectives: During the last few years, clinical, epidemiological, and pathological evidence has suggested that inherited alpha-1 antitrypsin [AAT] deficiency might play a role in the development of the fibromyalgia syndrome [FMS], probably because of the loss of AAT anti-inflammatory efficacy. The objective of this study was to estimate the prevalence and number of FMS patients, and their AAT phen

Functional dissociation between proforms and mature forms of proteinase 3, azurocidin, and granzyme B in regulation of granulopoiesis.

We previously demonstrated that secreted proform(s) of the neutrophil serine protease PR3 (proteinase 3) can down-modulate the fraction of normal human colony-forming unit granulocyte-macrophage (CFU-GM) in S-phase, whereas PR3 extracted from mature neutrophils lacks this ability. The objective of this study was to characterize the structural and functional dissociation between secreted proforms a

Sequence Variation and Haplotype Structure Surrounding the Flowering Time Locus FRI in Arabidopsis thaliana.

Linkage disequilibrium in highly selfing organisms is expected to extend well beyond the scale of individual genes. The pattern of polymorphism in such species must thus be studied over a larger scale. We sequenced 14 short (0.5-1 kb) fragments from a 400-kb region surrounding the flowering time locus FRI in a sample of 20 accessions of Arabidopsis thaliana. The distribution of allele frequencies,

Functional assessment of the pharynx at rest and during swallowing in partially paralyzed humans: simultaneous videomanometry and mechanomyography of awake human volunteers

BACKGROUND: Functional characteristics of the pharynx and upper esophagus, including aspiration episodes, were investigated in 14 awake volunteers during various levels of partial neuromuscular block. Pharyngeal function was evaluated using videoradiography and computerized pharyngeal manometry during contrast bolus swallowing. METHODS: Measurements of pharyngeal constrictor muscle function (contr