Popular Abstract in Swedish Bakgrund: Signalsystem Alla flercelliga organismer är beroende av informationsöverföring mellan celler. Det behövs signaler från andra celler för att reglera tillväxt, ämnesomsättning m. fl. funktioner i olika vävnader. Oftast överförs signalerna via kemiska ämnen som antingen verkar i hela kroppen (hormoner) eller lokalt. När dessa ämnen når målcellen, binds de till eThe cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, as

Research programs regularly compete to achieve the same goal, such as the discovery of the structure of DNA or the construction of a TEA laser. The more the competing programs share information, the faster the goal is likely to be reached, to society’s benefit. But the “priority rule”-the scientific norm according to which the first program to reach the goal in question must receive all the credit

This paper describes the error-correcting capability of a convolutional code when transmitting close to capacity. We show that it is the combination of average burst length and first event error probability that allows us to better describe the error-correcting capability of a code

During the last ten years a rapid progress has been made in the development of analytical methods for a fire engineering design of load bearing structures and structural members. In a long-term perspective, the development then goes towards an analytical design, directly based on a natural fire exposure, specified with regard to the combustion characteristics of the fire load and the geometrical,

Shear banding in sand is an emergent fine-scale mechanism whose characteristic length scale is only a few particles. X-ray scanning a sand specimen under loading allows the analysis of the kinematics of individual grains and grain contacts during deformation. This paper summarises results from one such test performed on Hostun sand, and discusses some key issues that must be addressed in order to

Popular Abstract in Swedish Randomiserade, kontrollerade studier av patientutbildning med tonvikt på patienter med hjärtsvikt och patienter med ledsjukdomar.För att förbättra behandling och omhändertagandet av patienter med kroniska sjukdomar måste kontrollerade studier med olika mål och effektvariabler utföras. En begränsning i många studier är att patientmaterialet är selekterat och patient- proIn order to improve the treatment and care of patients with chronic diseases, controlled studies have to be performed continuously. It is widely believed that giving education/information to patients will increase their knowledge and compliance, which will decrease medical events and cost. Most educational activities in clinical practice are not based on evaluated models of effective disease manag

Popular Abstract in English Nowadays, cutting-edge technologies require devices to be small, ultrafast, and operational in a wide range of regimes. To fulfill these requirements we need to go beyond the traditional materials, i.e. to solids with novel, unconventional and tailorable properties. Great progress in this direction is conjectured to stem from materials in which the effect of inter-partiCutting-edge technology needs small, ultrafast devices, operational in a wide range of regimes. This calls for solids with novel, unconventional and tailorable properties. Great progress is expected from materials in which electron-electron and electron-phonon correlations strongly affect the dynamics ( i.e. "unforeseen" useful properties are expected to be most likely found in systems with comple

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Popular Abstract in SwedishElektronen har, bortsett från sin massa, två grundläggande fysikaliska egenskaper som är av största vikt för denna avhandling i synnerhet och världen i allmänhet: laddning och spinn. Den förra egenskapen har i tiotals decennier använts inom det framgångsrika området elektronik. Den andra ger nu framför våra ögon upphov till det nya och fascinerande ormrådet spinntronik, This thesis deals with single-electron tunneling in transistor-like devices in which the central electrode is either a metal nanoparticle (possibly ferromagnetic) or a molecular magnet. The investigated systems split into two different categories, depending on the size of the central island. The smaller islands, such as ultrasmall magnetic metal nanoparticles and Mn12 molecular magnets, are studie

Abstract in German Bei der interstitiellen photodynamischen Therapie dicker Hautläsionen hat sich herausgestellt, dass Veränderungen in der Gewebelichttransmission erzeugt werden, was eine unmittelbare Folge der Schwankungen des Gesamtblutvolumens und der Sauerstoffsättigung ist. Zur Simulation der Energiedichte- und der Gesamtlichtdosisverteilung im Zielgewebe wurde in zwei Fällen eine Finite-EleInterstitial photodynamic therapy on thick skin lesions has been shown to induce changes in tissue light transmission as a direct consequence of variations in total blood volume and oxygen saturation. A finite element method was used in order to simulate the fluence rate distribution and total light dose throughout the target tissue for two cases. The first case constitutes a pre-treatment model w