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Mannosyl β-C-1 amidotriazoles have previously been reported to have higher selectivity for galectin-9N (N-terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin-3. This study further investigated this by synthesis of mono- and bis-aryltriazolyl mannoside analogues to known high-affinity galectin-3 galactosyl-derived inhibitors. Following
Target cell entry of HIV-1 is dependent on the binding of gp120, the outer component of the viral envelope glycoprotein complex (Env), to CD4 and a coreceptor, preferentially CCR5 or CXCR4. Still, other interactions may also contribute to the infectivity of the virus. One such interaction is between the highly glycosylated gp120 and carbohydrate-binding proteins, such as galectins. Here, we studie
The pressure to design, develop and implement systems that exploit the potential of technological innovation in effective and efficient ways that contribute to the organisational goals never ceases. Post 1945 industrialisation evolved from mechanisation of industrial processes through to computerisation to the age of digitalisation and beyond. From the study of mechanisation of work in coal mining
This chapter discusses trade-offs that need to be struck while developing Unmanned Aircraft Systems (UAS) operations. Ten trade-offs are outlined, pertaining to technical systems, to human operators, and to the combined sociotechnical system in its operational and organizational environment, which have implications for Human-Systems Integration (HSI) in multiple phases of the systems engineering l
BACKGROUND: The incidence of postoperative pulmonary complications (PPCs3) following abdominal surgery varies across surgical specialties. It remains unclear to what extent the incidence of PPCs is attributable to known patient-related factors and anaesthesia duration, rather than to differences inherent to the surgical specialty itself.METHODS: Post-hoc analysis of an observational study describi
This chapter examines the Iranian state-produced film The Golden Collars as a tool of regime propaganda, focusing on how it constructs narratives of heroes and villains within the context of the 2009 post-election protests. It shows how the Islamic Republic, through state media, portrays foreign intelligence services—particularly those of the United States, United Kingdom, and Israel—as orchestrat
Current strategies to reduce the climate impact of production and consumption are insufficient to meet the pressing targets of the Paris Agreement. To expand visions of the possible ‘solution space’ in climate transitions, we explore a framework based on two dichotomies centred around the role of labour and the composition of economic output. From these dichotomies we sketch out four pathways for
Whereas the link between impaired male fertility and risk of testicular and prostate cancer is well established, studies investigating non-reproductive cancer risk among men with impaired reproductive function are scarce and show conflicting results. The aim of the study was to compare the risk of developing non-reproductive cancers in men achieving paternity through assisted reproduction as compa
INTRODUCTION: Intracranial haemorrhage (ICH) is the most serious complication in infants and children with severe congenital bleeding disorders causing substantial mortality and long-term neurological morbidity. The neonatal period carries the highest risk, particularly in severe haemophilia and rare factor deficiencies. We review the epidemiology, risk factors, prevention, recognition, management
BACKGROUND: There is limited information concerning the current practice of intraoperative mechanical ventilation in obese patients, and the optimal ventilator settings for these patients are debated. We investigated intraoperative ventilation parameters and their associations with the development of postoperative pulmonary complications (PPCs) in obese patients.METHODS: We performed a secondary a
Background: Anaemia is frequently recorded during preoperative screening and has been suggested to affect outcomes after surgery negatively.Objectives: The objectives were to assess the frequency of moderate to severe anaemia and its association with length of hospital stay.Design: Post hoc analysis of the international observational prospective 'Local ASsessment of VEntilatory management during G
Bakgrund: Preoperativ anemi är en välkänd riskfaktor för ett sämre kirurgiskt utfall. Hos patienter med flera riskfaktorer för postoperativa komplikationer är anemi den som lätt kan hanteras inom den tillgängliga tidsramen före operationen. I de fall denna hantering inte genomförs är det dock viktigt att förstår dess negativa påverkan jämfört med andra riskfaktorer. Denna studie syftade till att u
BACKGROUND: Early-career researchers (ECRs) play a vital role in scientific progress; however, academic environments and personal characteristics may influence their mental health and capacity to work. This study explored factors associated with mental health among ECRs in dementia research (ECDRs).METHODS: We analyzed data from an international cross-sectional survey of 283 ECDRs using a logistic
Bakgrund Inläggning av central venaccess, exempelvis central venkateter (CVK), är en invasiv åtgärd som kräver sterila betingelser för att förhindra introduktionen av mikroorganismer till blodbanan med en ökad risk för kolonisation respektive kateterrelaterad infektion. Med ett strukturerat arbetskoncept kan man uppnå en infektionsincidens nära noll. Flera aspekter är betonade i riktlinjerna, men
Background: Reuse of sterile textiles could potentially reduce the carbon footprint of operating theatres. The aim of this mixed-methods study is to gain a deeper understanding of the implementation of reusable drapes and gowns across different contexts through applying the Consolidated Framework for Implementation Research (CFIR).Methods: A mixed-methods analysis was performed of cross-sectional
Autonomous robots capable of turning natural-language instructions into reliable physical actions remain a central challenge in artificial intelligence. Here we show that connecting a large language model agent to the robot operating system enables a versatile framework for embodied intelligence, and we release the complete implementation as freely available open-source code. The agent automatical
