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In this paper I investigate the petitions to invalidate forced marriages submitted to the Apostolic Penitentiary during the pontificate of Pope Innocent VIII (1484-1492). The supplications will be analyzed both in relation to the late medieval scholarly discussion of force and fear as impediment to marriage, and in relation to the lived reality that emerges in the petitioner’s narratives. The Peni

Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac

Background: Dementia is a global public health challenge, with Alzheimer's disease (AD) and vascular dementia (VaD) being the most prevalent subtypes. Air pollution is a potential risk factor for dementia, but few studies separate AD and VaD. Objective: This study aims to investigate whether exposure to air pollution is associated with the incidence of AD and VaD. Methods: This study involved 30,2

Recent research has indicated that machining of titanium alloys with uncoated cemented tungsten carbide tools fulfil the criteria for Kirkendall porosity. If this occurs during machining, it could contribute to the type and rate of tool wear, compromising the tools structural integrity close to the edge line within the contact zone. In this study, voids were observed at the tool-workpiece contact

This paper documents how the advent of the limited liability corporation contributed to the diffusion of steam technology during Sweden's industrialization. Using longitudinal establishment-level data, we show that incorporation sharply raised the probability that industrial establishments adopted steam. Incorporation facilitated technology adoption partly by enabling smaller establishments to exp

To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients. Somatic alterations in drug-response genes, most commonly in TP53 and IKZF1 (64%), were highly enriched in e

Sorption-enhanced steam reforming (SorESR) is an advanced thermochemical process integrating in-situ CO2 capture via solid sorbents to significantly enhance hydrogen production and purity. By coupling CO2 adsorption with steam reforming, SorESR shifts the reaction equilibrium toward increased H₂ yield, surpassing the limitations of conventional steam reforming (SR). The efficacy of SorESR critical

Purpose: A cancer diagnosis and treatment pose significant physical and psychological challenges. The study aimed to explore factors associated with distress over time in women diagnosed with breast cancer undergoing radiotherapy (RT) with access to a digital information tool, specifically examining if factors such as health literacy and self-efficacy had any influence on distress. Methods: In thi

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of striatal neurons and motor-cognitive decline. While current gene-targeting approaches aiming at reducing somatic instability show promise – especially in case of early treatment – they cannot restore the already compromised neuronal circuitry at advanc

Context In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II. Objective The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a

Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes

Proper arterial versus venous endothelial lineage identity is required to establish a hierarchical network of arteries and veins and prevent the occurrence of life-threatening arteriovenous malformations. The molecular mechanisms that govern arteriovenous lineage specification remain however incompletely understood. Here, we demonstrate that the transcription factor Prdm16 is expressed in arterial

This thesis investigates the role of trust in the context of decentralised finance (DeFi). Representing a new paradigm shift in finance, DeFi emerge from the technological developments that we have witnessing in the last decades, particularly decentralised ledger technologies (DLTs) of which Blockchain is perhaps the most popular. DeFi is changing the way that firms raise financial capital and a c

Background: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health. Methods: Data from the World Populati

Giant number fluctuations (GNFs), whereby the standard deviation ΔN in the local number of particles ⟨N⟩ grows faster than sqrt[⟨N⟩], are a hallmark property of dry active matter systems with orientational order, such as a collection of granular particles on a vibrated plate. This contrasts with momentum-conserving ("wet") active matter systems, such as suspensions of swimming bacteria, where no t

We study the electronic structure of bulk 1T-TaSe_{2} in the charge-density wave phase at low temperature. Our spatially and angle-resolved photoemission data show insulating areas coexisting with metallic regions characterized by a chiral Fermi surface and moderately correlated quasiparticle bands. Additionally, high-resolution laser angle-resolved photoemission reveals variations in the metallic

The dynamics of atmospheric CO2 concentrations during and following the last deglaciation have mainly been ascribed to carbon release from and uptake in oceans, primarily in the Southern Ocean. But recent studies also point toward a terrestrial influence. We quantify dynamic changes to northern terrestrial carbon stocks from the Last Glacial Maximum (21,000 years) until present at millennial time

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Research objective 1: to assess the effects of different oxygen saturation targets for the delivery room resuscitation of preterm infants. Research objective 2: to assess the effects of different titration strategies for the delivery room resuscitation of preterm infants.