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Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow.

AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothe

Structural Anisotropy in Polar Fluids Subjected to Periodic Boundary Conditions

Abstract in UndeterminedA heuristic model based on dielectric continuum theory for the long-range solvation free energy of a dipolar system possessing periodic boundary conditions (PBCs) is presented. The predictions of the model are compared to simulation results for Stockmayer fluids simulated using three different cell geometries. The boundary effects induced by the PBCs are shown to lead to an

Perturbed cellular response to brain injury during aging

Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are only partly understood. Therefore, studying the basic mechanisms underlying structural and functional recovery after brain injury in aged subjects is of considerable clinical interest. Behavioral and cytological analyses of rodents that have

The effect of climate conditions on inter-annual flowering variability monitored by pollen traps below the canopy in Draved Forest, Denmark

Since 1967 annual pollen deposition has been monitored in the semi-natural mixed deciduous woodland Draved Forest by the Geological Survey of Denmark. In this paper, we analyse the variability in pollen accumulation rates for the eight most common deciduous trees, and their relationships to monthly temperature and precipitation. High summer temperatures in the year before flowering have a positive

Applicability Domain Dependent Predictive Uncertainty in QSAR Regressions

Predictive models used in decision making, such as QSARs in chemical regulation or drug discovery, call for evaluated approaches to quantitatively assess associated uncertainty in predictions. Uncertainty in less reliable predictions may be captured by locally varying predictive errors. In the current study, model-based bootstrapping was combined with analogy reasoning to generate predictive distr

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

SufA, which belongs to the subtilisin-like serine protease family, contains a non-canonical Asp-His-Ser catalytic triad. Under in vitro conditions, SufA is capable of human fibrinogen hydrolysis leading to inhibition of fibrin network formation, thus suggesting its important role in the development and progression of Finegoldia magna infections. In addition, it has been demonstrated that SufA can

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Radical trachelectomy in conjunction with pelvic lymphadenectomy is an established, safe method to preserve fertility in selected cases of early cervical cancer. The majority of publications encompass radical trachelectomy performed vaginally preceded by a laparoscopic pelvic lymphadenectomy (Dargent's operation). The invasiveness of an open abdominal trachelectomy and the complexity of a traditio

Endotoxin injection attenuates rest-phase hypothermia in wintering great tits through the onset of fever

Endothermic animals in the boreal region experience considerable thermoregulatory costs in winter, especially during inactive periods when high demands cannot be met by increased food intake. This might necessitate a trade-off between resting thermoregulation and other energetically expensive processes, such as immune function, but this has rarely been investigated. We evaluated how immune activat

Prediction of hip displacement in children with cerebral palsy : development of the CPUP hip score

Hip displacement, defined in this study as a migration percentage (MP) of more than 40%, is a common, debilitating complication of cerebral palsy (CP). In this prospective study we analysed the risk of developing hip displacement within five years of the first pelvic radiograph. All children with CP in southern and western Sweden are invited to register in the hip surveillance programme CPUP. Incl

Cross-linking cellulose nanofibrils for potential elastic cryo-structured gels

Cellulose nanofibrils were produced from P. radiata kraft pulp fibers. The nanofibrillation was facilitated by applying 2,2,6,6-tetramethylpiperidinyl-1-oxyl-mediated oxidation as pretreatment. The oxidized nanofibrils were cross-linked with polyethyleneimine and poly N-isopropylacrylamide-co-allylamine-co-methylenebisacrylamide particles and were frozen to form cryo-structured gels. Samples of th

Partial migration in fishes: definitions, methodologies and taxonomic distribution.

Partial migration, where populations are composed of both migratory and resident individuals, is extremely widespread across the animal kingdom. Researchers studying fish movements have long recognized that many fishes are partial migrants, however, no detailed taxonomic review has ever been published. In addition, previous work and synthesis has been hampered by a varied lexicon associated with t

State responsibility beyond borders: what legal basis for Italy's push-backs to Libya?

This article takes Italy’s widely-debated 2009 push-backs to Libya campaign as a point of reference to address whether bilateral agreements for technical and police cooperation provide the legal foundation for the forced return of intercepted refugees to countries of embarkation. Through a detailed analysis of both the facts and the texts of the published and unpublished bilateral accords, it conc

The Importance of the Macroeconomic Variables in Forecasting Stock Return Variance: A GARCH-MIDAS Approach

This paper applies the GARCH-MIDAS (mixed data sampling) model to examine whether information contained in macroeconomic variables can help to predict short-term and long-term components of the return variance. A principal component analysis is used to incorporate the information contained in different variables. Our results show that including low-frequency macroeconomic information in the GARCH-

Source reconstruction by far-field data for imaging of defects in frequency selective radomes

In this paper, an inverse source reconstruction method with great potential in radome diagnostics is presented. Defects, e.g., seams in large radomes, and lattice dislocations in frequency selective surface (FSS) radomes, are inevitable, and their electrical effects demand analysis. Here, defects in a frequency selective radome are analyzed with a method based on an integral formulation. Several f

Environmental diplomacy: comparing the influence of business and environmental NGOs in negotiations on reform of the clean development mechanism

Although case studies exist of the influence of non-governmental organisations in international environmental negotiations, theoretical conclusions remain scattered, and the separation in previous literature between the study of environmental non-governmental organisations (ENGOs) and business and industry non-governmental organisations (BINGOs) reduces the generalisability of conclusions. The con

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern molecules. Extracellular histones belong to the latter group and their release has been described to contribute to the induction of systemic inflammatory reactions. However, little is known about their functions in the early immune response to an