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Background: Outcome measurement is essential to progress clinical practice and improve patient care. Aim: To develop a Core Outcome Set for best care for the dying person. Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the
Empirical research on the resilience of smart tourist destinations (STDs) to cybersecurity threats is scarce. The current research aims to address this gap by exploring cybersecurity risks within STDs and their resilience to withstand cyber threats. Employing a qualitative approach, we conducted 15 semi-structured interviews with cybersecurity experts and stakeholders in Dubai’s tourism and hospit
Frågorna hur den allmänna repressionsnivån och enskilda straff ska se ut placeras ofta antingen hos lagstiftare eller domare. Men för att på allvar kunna diskutera frågorna och vad som är önskvärt behövs gediget underlag och en öppenhet för frågornas komplexitet och olika infallsvinklar.
Objective: To estimate the size of regression to the mean (RTM) for common patient-reported outcomes in trials for knee osteoarthritis (OA). Design: Longitudinal cohort study; we included participants of the Osteoarthritis Initiative who fulfilled typical inclusion criteria for enrolment in a trial. These included: age 40–79 years, symptomatic knee OA, Kellgren-Lawrence grade 2–3, use of pain medi
Distinguishing between vagrancy and regular migration has proved to be challenging as vagrants may, in theory, act as pioneers in the establishment of new migration routes. Because migratory songbirds tend to follow the same orientation and migration route throughout their lives, age assessment can help to distinguish individuals which have already used a route (i.e. adults) from those using it fo
The paper shows, based on a case study of the production of a strategic plan at a fairly traditional university, the problems and potential meaninglessness of working with strategic plans in this type of setting, characterized by strong professional norms. Senior people involved in the strategy work raise strong doubts over, and distancing from, the process and outcome. Possible meanings of the st
Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue. Methods: MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason
The present study focuses on the computation of interfacial excess potential for the cohesive zones through which a brittle crack propagates in tungsten (W) twist grain boundaries (TGBs). Additionally, the influence of phosphorus (P) impurities is investigated. To this end, we have performed classical atomistic modeling of several ⟨110⟩ TGBs in their pristine and P-impurity segregated states. The
Background: Immune checkpoint inhibitors are now a part of the treatment arsenal for triple-negative breast cancer (TNBC) but refinement of PD-L1 as a prognostic and predictive biomarker is a clinical priority. We aimed to evaluate the relevance of novel PD-L1 immunohistochemical (IHC) thresholds in TNBC with regard to PD-L1 gene expression, prognostic value, tumor infiltrating lymphocytes (TILs),
How well patient perceived outcome reflects clinical measurements after arthroscopic lysis and lavage of the temporomandibular joint (TMJ) is not fully understood.The purpose of this study was to detect any correlation between patient reported outcome measures (PROM) and clinical follow-up measurements.Patients with internal derangement of the TMJ treated with arthroscopic lysis and lavage 2014–20
Purpose: Direct percutaneous access to the carotid artery (diPerCa) during endovascular aortic arch repair (EVAAR) can potentially present a minimally invasive access with lesser local adverse events. Techniques: A retrospective review of consecutive EVAAR between January 2018 and January 2024, in a tertiary referral center, was performed to identify cases, in which diPerCa was used. Patients who
This article further theorises and develops the notion of a threat of abandonment while trying to elucidate the applicability and usefulness of this concept in the case of Ukraine in its fight against Russia since 2014. If Ukraine perceives the European Union (EU) as weakened by multiple crises, it may translate this image into a scenario of less attention to Ukraine and its problems, and – ultima
Aims/hypothesis: A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is needed to guide risk stratification and prevention. We investigated the risk of infection in subgroups of individuals with type 2 diabetes according to indices of insulin sensitivity and beta cell function. Methods: We classified 7265 individuals with recently diag
