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Functionalization of a TB analogue through a six step synthesis has been performed, collecting valuable material for further synthesis towards a heptakis TB analogue and characterization of intermediates. Previous work in the Wärnmark group has produced this heptakis TB analogue and this project focused on following the worked out procedure and improving it where possible. The synthesis started fr

Galectins are an old fifteen-member protein family. Every galectin has one or two highly conserved carbohydrate recognition domains (CRDs) through which it binds their mutual ligand galactose. They are involved in various pathways such as signaling, autophagy and immune response. However, they also contribute to pathological functions including fibrosis, metastasis, cardiovascular diseases and dia

När man talar om framtiden finns det ett begrepp som dyker upp i nästan varje diskussion: "articiell intelligens". Vår fascination kring framtidens potentiellt självtänkande robotar speglas i hur mycket det diskuteras i alla yrkesgrupper just nu, oavsett om ämnet är koldioxidutsläpp, självkörande bilar eller automatiska inköpslistor. Men hur långt har egentligen maskininlärning kommit idThe task of Automated Essay Scoring (AES) has been active for more than half a century, starting with handcrafting statistical features used for linear regression, and currently being improved by the latest advancements in machine learning and natural language processing. Most current research uses some form of character or word embeddings to represent the essays rather than statistical features,

Med anledning av den stora vågen av flyktingar som under de senaste åren har sökt skydd inom Europas gränser, har åtgärder implementerats för att kontrollera deras inresa, vistelse, samt utvisning. Användandet av sådana åtgärder, så som förvarstagande, har både ökat och intensifierats i dess användning. Syftet med denna uppsats var därför att fokusera på den svenska praxisen angående verkställigheDue to the large influx of persons seeking refuge within European states in recent years, measures which control the entry, residence and expulsion of aliens have increased both in use and intensity. An example of such a measure is the detention of asylum seekers for administrative reasons. The purpose of this paper was therefore to focus on the Swedish practice concerning the administrative deten

With the Internet of Things era being here, more devices than ever are connected to the Internet, making the need for higher security greater. One important aspect of security to consider is encryption, which protects data from being read by unauthorized parties. Integrating cryptographic algorithms can be done in many ways and is usually dependent on restrictions of the area, speed, and power whe

Syfte: Syftet med uppsatsen är att undersöka huruvida två olika investeringsstrategier, Magic Formula och Momentumstrategin, kan generera abnormal avkastning på den europeiska aktiemarknaden utifrån fyra tillgångsprissättningsmodeller mellan juli 2000 och juli 2018. Uppsatsens bisyfte är att undersöka hur investeringsstrategierna utvecklas i förhållande till marknadsportföljen. Metod: Metoden som Purpose: The purpose of the thesis is to examine if two investment strategies, Magic Formula and Momentum strategy, are capable of generating an abnormal return on the european stock market according to four asset pricing models during the time period between July 2000 and July 2018. A secondary purpose is to investigate the investment strategies’ performance in relation to the market portfolio. M

Dagens vägskyddsanläggningar är baserade på gammal reläteknik och är byggda på liknande sätt som på 1940-talet. År 2014 påbörjades projekt-Alex av Trafikverket med mål att byta ut dagens vägskyddsanläggningar mot en mer modern och driftsäker anläggning. Detta genom att uppdatera tekniken i vägskyddsanläggningarna till ett databaserat system som ska standardiseras och inte vara så anläggningsspecifToday's level crossing security systems are based on old relay-based technology and have been constructed in the same way since the 1940s. In 2014, Project-Alex was initiated by Trafikverket to replace the current level crossing security systems with a more modern and reliable system. It is done by updating the technology in the level crossing security systems to a computer-based system that i

Roots play a key role in terrestrial carbon and water cycles, and therefore for the global climate system. They mediate plant evapotranspiration, influence photosynthetic processes and are responsible for atmospheric carbon transport into the pedosphere. Fine roots, in particular, are chiefly regulating water and nutrient uptake. Recent research has suggested that the representation of fine roots

To meet national and international emission targets, the Swedish building sector needs to drastically reduce its carbon dioxide emissions, and to do so, a change in building techniques and materials is needed. Bio-based materials contribute to less emissions than conventional materials, like steel and concrete, but remain rather unknown to modern building sciences. This study aimed to increase kno

The 1st of August 2018, Denmark became one in the line of European countries that during the last decade have introduced a ban towards face covering in public places. Even though this ban is formulated in a general way, which includes all face coverings that prevent others from noticing facial expressions, the debate surrounding the ban have been concentrated around women who wears full cover veil

Galectins are family of cytosolic proteins that function as both positive and negative modulators of various cell processes. Galectin-3 has an altered expression pattern in pathophysiological processes, such as cancer or chronic inflammation, which makes it an interesting target for pharmaceutical research. The treatment of galectin-3 ill-regulation was shown effective in serious conditions like i

This paper looks into the responses of cocoa farming households to a negative shock in the global cocoa price with regards to how they invest into the future of their children. The specific child outcomes of focus are child employment rates, school attendance, and household expenditure on schooling and related activities. A differences-in-differences approach is used in line with previous literatu

I takt med att det globala samhället blir större och större och mer och mer utvecklat, kräver mänskligheten mer energi. Idag kommer mycket energi runt om i världen från kol, olja och naturgas, så kallade icke-förnybara energikällor. Dessa är begränsade resurser som kommer att ta slut om vi använder dem ens i närheten av den utsträckning vi gör idag. Dessutom bidrar deras användning till en ökad väSyntheses of novel homo- and heteroleptic iron(II) N-heterocyclic carbene complexes have been pursued. The heteroleptic complexes contain donor-acceptor structures meant to enhance their sensitization activity when operating as a part in a dye sensitized solar cell by slowing down charge recombination. Syntheses of two related heteroleptic complexes were completed but require additional characteri

This report examines the concept of validating financial risk models, specifically Value-at-Risk, and compares the required regulatory tests with more advanced validation methods based on testing different martingale characteristics. The validation methods are considered in a classic backtesting scenario on a real custom portfolio, a Monte Carlo experiment to compare the empirical power on differe

Extracellulära vesiklar (EV) är membranbundna vesiklar som utsöndras från de flesta celler och släpps ut i biologiska vätskor. De är 30 - 5000 nm i diameter stora och innehåller biologiska molekyler som RNA, lipider och proteiner. De spelar en nyckelroll för kommunikationen mellan cellerna, så kallad, intercellulär kommunikation. EV är ett utmärkt medel för långdistans kommunikation mellan celler.The aim of this thesis was to reveal how nano-sized extracellular vesicles (EVs) isolated from human breast milk and Aascaris suum, parasitic worm incubation media interacts with hydrophilic, hydrophobic and DOPC surfaces and colloidally characterize EVs and EV fluids by determining their hydrodynamic radius and zeta potential. Dynamic Light Scattering (DLS) was used to determine the size and zet

A visit of an art exhibition can lead to feelings of frustration, exclusion, and not-being welcomed.Above all exhibitions of contemporary and modern art can due to the often conceptuel and abstract caracter of the artworks experienced as exclusive.As many researches has shown a museum visit become meaningful to us if a relation to what is seen can generates.Not just the consumption of cultural sup

Adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are the most common forms of lung cancer. These two subtypes of lung cancer are usually classified by visual inspection clinically. Our aim is to design an effective strategy based on convolutional neural networks to classify histopathology slides of these two types of lung cancer. With augmentation of the histopathology slides, different cl

Fruits and vegetables (F&V) waste in retail stores linked to consumer dissatisfaction has led to an increased interest in new preservation solutions to extend the shelf-life of fresh produce. In this study, the potential of controlled atmosphere (CA) combined with optimal temperature and relative humidity (RH) to extend the shelf-life of fruits and vegetables (F&V) in retail stores for shoReducing fruits & vegetables waste in retail stores with an innovative preservation solution Storing fruits and vegetables under controlled atmosphere and optimal temperature and humidity conditions could help improving consumer satisfaction and visual quality of fruits and vegetables in retail stores. The impact of an innovative solution on the shelf-life of fruits and vegetables and its env

This thesis addresses the research problem of volatile growth and in particular economic shrinking in developing countries. A single case study of Nigeria drawing on qualitative as well as quantitative data assesses four potential factors behind the country’s frequent and high shrinking rates between 1960 and 2017. The study finds a lack of structural transformation, productivity and diversificati