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Through an analysis of the FDA’s approval of the controversial anti-influenza drug Relenza (zanamivir), we interrogate distinct social scientific theories of pharmaceutical regulation. We investigate why, despite internal negative opinions and an Advisory Committee’s non-approval recommendation, the FDA approved Relenza in the late 1990s. Based on a close reading of FDA documents, we show how agen
Det finns många ”första” knutna till Karin Kock. Hon var den första kvinnan som gjorde karriär som akademisk nationalekonom, blev docent i nationalekonomi, fick professors namn i nationalekonomi, utnämndes till statsråd och till chef för en större statlig myndighet. Hon var en hårt arbetande och framgångsrik pionjär i den manliga värld som national- ekonomi och ekonomisk politik utgjorde. Hon röjd
Purpose: The purpose of this study is to enhance the thermal performance in the labyrinth channel by different ribs shape. The labyrinth channel is a relatively new cooling structure to decrease the temperature near the trailing region of gas turbine. Design/methodology/approach: Based on the geometric similarity, a simplified geometric model is used. The k − ω turbulence model is used to close th
The study aim was to report survival and morbidity of all patients in Sweden with peritoneal mesothelioma treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as well as investigate whether the survival has increased on a population level since this treatment was nationalized 2011. Study data were collected from the Swedish HIPEC registry and the Swedish N
This paper models ‘no war, no peace’ situations in a game theoretical framework where two countries are engaged in a standoff over a military sector. The first main objective is to identify rational grounds for such situations and, more precisely, for the explicit equilibria that lead to such situations. It is demonstrated that both countries gain the same payoff from being in this continuous stat
Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and C-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female GIP recep
This article is a revised version of a keynote given at the 18th Nordic Conference on Systematic Theology: Hope in Dark Times, held in Stavanger on 10–13 January 2019. The aim of the article is to ponder how Jewish and Christian discourses on hope can contribute in a critical way to contemporary political and philosophical discussions of hope. Taking its cue from the biblical idea of messianic red
Purpose: The purpose of the study was to investigate if surface guided radiotherapy (SGRT) can decrease setup deviations for tangential and locoregional breast cancer patients compared to conventional laser-based setup (LBS). Materials and Methods: Both tangential (63 patients) and locoregional (76 patients) breast cancer patients were enrolled in this study. For LBS, the patients were positioned
The world of cult cinema is dotted with numerous films that are often characterised by event-like evening screenings in independent or art-house cinemas years or even decades after the film’s initial release. One film synonymous with the cult cinema circuit is Tommy Wiseau’s The Room (2003), which has often been hailed as the ‘Citizen Kane of bad movies’ due to the film’s lack of artistic vision,
Urban planning is the most relevant decision-making process affecting urban regulating ecosystem services. However, a clear understanding of the effects of planning decisions on both the supply and demand of urban regulating ecosystem services is still lacking. To support planners in enhancing urban regulating ecosystem services, there is a need to understand what variables are at stake and how ch
Urban spatial development is a crucial issue for spatial planning and urban governance, ultimately determining cities’ sustainability. While a set of spatial strategies to address urban development are progressively gaining international consensus, their actual applicability is still contested. An interesting test-bed is represented by the European Union (EU), where common spatial strategies have
As urban systems continue to grow worldwide, urban peripheries increase in number and typologies, which makes their planning a challenge for sustainable development. The aim of this article is to explore approaches and challenges related to the application of sustainable planning to urban peripheries. We reviewed the content of 102 papers related to sustainable planning in urban peripheries by app
Nature-based recreation is among the most relevant ecosystem services supplied by urban green infrastructure, affecting citizens' physical and mental wellbeing. Providing adequate green spaces for nature-based recreation is among the main goals of urban planning, but commonly-used indicators offer a partial view on the issue. Innovative methods and approaches, such as the ESTIMAP-recreation model,
In cities, land-use decisions made during planning processes determine the availability of ecosystem services fundamental to the wellbeing of urban population. Hence, the inclusion of ecosystem services in planning is essential to promote sustainable urban development. This article investigates to what extent ecosystem services are currently included in urban plans. The ultimate objective is to un
This study explores the use of ecosystem service (ES) knowledge to support urban planning in the assessment of future scenarios. The case study concerns the prioritszation of brownfield regeneration interventions in the city of Trento (Italy). Alternative planning scenarios considering the conversion of existing brownfields into new urban parks are assessed and compared. The assessment focuses on
