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Urban Expansion and its Relation to the Urban Heat Island Effect: A Case Study of Tripoli, Libya

Urban expansion is a defining feature of rapidly growing cities and has important implications for urban thermal behaviours, particularly in hot and semi-arid regions that are increasingly vulnerable to the effects of climate change. Tripoli, the capital of Libya, has experienced substantial urban growth over recent decades under conditions of weak planning and uneven development. Despite this, th

Low levels of IgG2 and pneumococcal antibodies as predictors of benefit from IgG replacement in IgG subclass deficiency

Immunoglobulin G subclass deficiencies (IgGSD) are associated with recurrent respiratory tract infections. Tools to identify patients with IgGSD who benefit from immunoglobulin G replacement therapy (IgGRT) are lacking. This crossover study evaluated the number of antibiotic-demanding infections on and after up to 18 mo off IgGRT in 28 patients with IgGSD. Pneumococcal antibodies against 21 seroty

Conformational flexibility and transient structure of the proline-rich domain in p53

The proline-rich domain (PRD) of the tumor suppressor p53 plays a central role in modulating conformational dynamics and molecular interactions, yet its intrinsic structural behavior remains incompletely understood. Here, we combine extensive all-atom molecular dynamics simulations with biophysical validation to characterize the conformational ensemble of the p53 PRD. The domain behaves as an intr

Metformin use and the risk of incident osteoarthritis among individuals with diabetes : a register-based nested case-control study

OBJECTIVE: To evaluate the association between metformin use and incident osteoarthritis (OA) in people with diabetes and the impact of dosing. DESIGN: Nested case-control study within a cohort of >1.4 million individuals from Sweden. PARTICIPANTS: Participants were aged 35-80 years in 2005, without diabetes or OA. We identified persons with incident diabetes between 2006 and 2016 and excluded tho

Support, Monitoring, and Reminder Technology for Mild Dementia (SMART4MD) for People With Mild Cognitive Impairment and Their Informal Caregivers: Cost-Effectiveness Analysis

Background:Support, Monitoring, and Reminder Technology for Mild Dementia (SMART4MD), a customized tablet app, was developed to improve or maintain the quality of life of people with mild cognitive impairment (MCI) and their informal caregivers.Objective:This study conducts an 18-month economic evaluation of the SMART4MD app, in addition to standard care, compared with standard care alone in Swede

Comparison of photon-counting CT with energy-integrating CT in temporal bone imaging : an anthropomorphic phantom study

Background: Photon-counting computed tomography (PCCT) is an emerging technique under evaluation for temporal bone imaging. Its capacity for radiation dose reduction while maintaining diagnostic image quality (IQ) requires further study. Purpose: To evaluate how PCCT compares to energy-integrating CT (EICT) in temporal bone imaging in terms of IQ and visualization of anatomical landmarks, at a cli