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BACKGROUND: Moderate differences in efficacy between adjuvant chemotherapy regimens for breast cancer are plausible, and could affect treatment choices. We sought any such differences.METHODS: We undertook individual-patient-data meta-analyses of the randomised trials comparing: any taxane-plus-anthracycline-based regimen versus the same, or more, non-taxane chemotherapy (n=44,000); one anthracycl
BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year re
This thesis assesses, through self-reflective practice, how the instruments of the tuba family have functioned as interfaces between composers and performers from the earliest records to the present day. A lack of knowledge surrounding the instruments and their capabilities and limitations has persisted since they were first employed by composers in the late seventeenth century, which suggests tha
In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI range
Research centers represent a specific organizational format for linking the traditional university organization with external actors, goals, and processes in time-limited, concentrated efforts of research and collaboration. Yet, the center format contains large variations, and centers act as interfaces between university organizations, societal actors, and research funders in multifaceted ways. In
The concept of hot carrier solar cells (HCSCs) has been proposed as a promising yet elusive path toward high-performance photovoltaics (PV), capable of surpassing the Shockley-Queisser limit by recycling energy that would otherwise be lost during thermalization. Lead halide perovskites (LHPs) have emerged as highly promising materials for PV applications. The reports of slow hot carrier (HC) cooli
BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen.METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,4
Atomic layer etching (ALE) is a cyclic technique based on self-limiting processes, such as reactive gas adsorption and material removal by low-energy ion bombardment 1,2. In a typical ALE process Ar+ ions with energies of 20-60 eV are used to desorb the reaction products, e.g. SiClx for the Si ALE. Compared to a corresponding continuous reactive ion etching (RIE), where the ion energies often exce
The use of hard X-ray transmission nano- and microdiffraction to perform in situ stress and strain measurements during deformation has recently been demonstrated and used to investigate many thin film systems. Here a newly commissioned sample environment based on a commercially available nanoindenter is presented, which is available at the NanoMAX beamline at the MAX IV synchrotron. Using X-ray na
Senescence is a negative prognostic factor for outcome and recovery following traumatic brain injury (TBI). TBI-induced white matter injury may be partially due to oligodendrocyte demise. We hypothesized that the regenerative capacity of oligodendrocyte precursor cells (OPCs) declines with age. To test this hypothesis, the regenerative capability of OPCs in young [(10 weeks ±2 (SD)] and aged [(62
To mitigate ongoing insect biodiversity declines, there is a need for efficient yet accurate monitoring methods. The use of traditional catch-based survey methods is constrained both by costs and need for expertise for manual taxonomic identification. Emerging methods, such as eDNA and robotic sorting, have the potential to reduce workload but still require resource-intensive sample collection in
Titanium alloys display anisotropic deformation properties due to the hexagonal close-packed (hcp) crystal structure of the α-phase. When subjected to localised deformation during machining, this behaviour influences fluctuations in the cutting force response of the material as the tool encounters grains of different orientations. In this research, cutting force signals acquired during face turnin
The purpose of this study was to explore the experiences of perioperative nurses in Sweden (ie, operating theater nurses) associated with caring for a donor patient during organ procurement procedures. We sought to determine the nurses’ main concerns and how they dealt with them. Using constructivist grounded theory methodology, our participant sample included 10 nurses, one of whom self-identifie
Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive
When mattering is defined as being able to disseminate ideas on a global scale, not all universities and researchers matter equally. Along with many other factors, geographical location can be a source of inequality in the science system, which is characterized by a persistent core–semi-periphery–periphery structure. Collaboration between high-, middle-, and low-income countries, frequently enable
