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Synthetic Strategies toward Arylene-Based Anion Exchange Membranes with High Local Molecular Flexibility

Durable and high-performing anion-exchange membranes (AEMs) are key components in alkaline water electrolyzers and fuel cells. As potentially more sustainable and cost-effective alternatives to proton exchange membrane (PEM)-based systems, AEM-based devices can operate without platinum-group metal catalysts or perfluorinated polymers. However, their broader practical implementation remains limited

Stop! Go! What can we learn about family planning from birth timing in settler South Africa, 1800-1910?

We revisit the discussion on family limitation through stopping and spacing behavior both prior to and during the fertility transition. Using the birth histories of 13 519 settler women in nineteenth century South Africa we find no evidence of parity specific spacing prior to the transition. In addition we find no differences in spacing behavior based on differences in time invariant economic and

Adverse Early-Life Conditions and Their Impact on the Marriage Market and Social Mobility: The Poznań Birth Cohort, 1830–1855

This study investigates the long-term social consequences of early-life exposure to adverseconditions in nineteenth-century Poznań. Using linked individual-level records from thePoznań Historical Population Database for birth cohorts 1830–1855, we examine howprenatal stress, infant mortality, early-childhood disease burden, and fluctuations in rye pricesinfluenced the likelihood of marriage and in

Small Viruses, Big Battles: Experimental exploration of phage diversity and anti-phage defence mechanisms

Bacteriophages exert strong selective pressure on bacterial populations and play a central role in shaping microbial evolution. In response to phage predation, bacteria have evolved diverse antiphage defence mechanisms that interfere with viral replication through a wide range of molecular strategies. Recent genomic studies have revealed a rapidly expanding repertoire of candidate defence systems,

Prospective study of patients with immune checkpoint inhibitor-induced hepatitis; characterization of liver injury, outcome of therapy, and management of steroid-unresponsive and steroid-dependent hepatitis

BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre

Prevalence of self-reported pain in patients 5 years after rectal cancer treatment : results from the prospective QoLiRECT cohort study

BACKGROUND AND PURPOSE: Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference po

On the random Interface models of microemulsions as the foundation of hydrophilic-lipophilic difference - net average curvature (HLD-NAC) equation of state

The HLD-NAC (Hydrophilic-Lipophilic Difference - Net Average Curvature) equation of state is a powerful semi-empirical framework used to predict the phase behavior, solubilization, and interfacial properties of surfactant-oil-water (SOW) systems it is based on the assumption of a normalized curvature for an idealized microemulsion, represented as the coexistence of two fictitious phases: water dro

Are We Creating a “World Without Us”? : Global Responsibility and Annihilism in the Works of Günther Anders, Karl Jaspers, and Hans Jonas

This essay argues that the concept of global responsibility, as articulated in the works of Karl Jaspers and Hans Jonas, was anticipated in Günther Anders' 1956 opus, Die Antiquiertheit des Menschen. By tracing the phases of Anders' negative anthropology—from his pathology of freedom to the Promethean differential andhis critique of what he considers to be an annihilistic Western stance—I examine

Medial temporal lobe Tau-Neurodegeneration mismatch from structural imaging and plasma biomarkers

While tau pathology is closely associated with neurodegeneration in Alzheimer's disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-

The Power of Flow Cytometry in the Cytopathologic Diagnosis of Lymphoid Lesions

Abstract – Background: Cytological examination of a fine-needle aspirate (FNA) is a minimally invasive modality that is increasingly used in the diagnosis of lymphoma. Flow cytometry and other ancillary tests make an important contribution to the diagnostic value of FNAs of lymphoid lesions. This review follows the recent publication of the first edition of the WHO Reporting System for Lymph Node,