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Introduction: Primary prophylaxis is the gold standard in severe haemophilia A (SHA) but time to escalate the prophylaxis regimen varies. Aim: Assess prophylaxis implementation and long-term joint health outcomes in SHA with primary prophylaxis. Methods: Adult male patients born after 1980, with SHA on primary prophylaxis, started before the age of 3 years and second joint bleed, and no history of
Acoustic testing is crucial in the aero-engine design process, providing valuable information about the sound field in terms of acoustic modes. The conventional use of a uniform sampling array limits the achievable resolution for a given number of sensors, necessitating the use of a large number of sensors to achieve high-resolution estimates. This limitation may be overcome using a non-uniform se
Background: Patients with cardiac implantable electronic device (CIED) and Staphylococcus aureus bacteraemia (SAB) are at risk of having CIED infection, pocket infection or endocarditis. To avoid treatment failures, guidelines recommend that the CIED should be extracted in all cases of SAB butrecent studies indicate low extraction rates and low risk of relapse. The aim of the study was to describe
Background: Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system and the major non-traumatic cause of permanent disability in young adults. Several migration studies have been performed over the years suggesting a pattern of higher disease disability in certain ethnic groups. To our knowledge, differences in disease progression in immigrants have n
This work investigates the effects of atmospheric-pressure nanosecond (ns) pulsed plasma discharges on NH3/air flames using optical emission spectroscopy (OES). Firstly, spatially-resolved OES in the 200–800 nm range of NH3/air flames with and without discharges are presented to identify the plasma-induced excited species (such as N2* and H*). Then, time-resolved OES with ns timescale resolution a
Background: In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405). Methods: The airwa
At Lund University and Skåne University Hospital in Lund, Sweden, we have, as the first clinic, modified a clinical Elekta Precise linear accelerator for convertible delivery of ultrahigh dose rate (FLASH) irradiation. Whereas recently published reviews highlighted the need for standardised protocols for ultra-high dose rate beam dosimetry to be able to determine the true potential of FLASH irradi
Highly anisotropic cellulose nanofibrils can solidify liquid water, creating self-supporting structures by incorporating a tiny number of fibrils. These fibrillar hydrogels can contain as much as 99.99 wt% water. The structure and mechanical properties of fibrillar networks have so far not been completely understood, nor how they solidify the bulk water at such low particle concentrations. In this
Small-angle X-ray scattering (SAXS) is used to demonstrate the presence of density fluctuations in ambient water on a physical length-scale of ≈1 nm; this is retained with decreasing temperature while the magnitude is enhanced. In contrast, the magnitude of fluctuations in a normal liquid, such as CCl 4, exhibits no enhancement with decreasing temperature, as is also the case for water from molecu
We consider linear mappings on the 2-dimensional torus, defined by T ( x ) = A x ( mod 1 ) , where A is an invertible 2 × 2 integer matrix, with no eigenvalues on the unit circle. In the case det A = ± 1 , we give a formula for the Hausdorff dimension of the set { x ∈ T 2 : d ( T n ( x ) , x ) < e − α n for infinitely many n } .
The Events Research Programme (ERP) was a multi-disciplinary study undertaken during the COVID-19 pandemic to investigate SARS-CoV-2 transmission risks and mitigations around the reopening of mass events in the UK in 2021 – including a behavioural study, exploring how non-pharmaceutical interventions (NPIs), such as social distancing, pre-event virus testing, and the use of face coverings might en
In 1689 the Danish royal antiquary Thomas Bartholin the Younger (1659–1690) published a celebrated antiquarian work on the attitudes, customs, and rituals of the pagan inhabitants of Scandinavia. It has been deemed significant both for influencing the development of the historical conception of the ‘Viking Age’ in the eighteenth and nineteenth centuries, and for introducing a rigorous source-criti
Den här avhandlingen analyserar en korpus av publicerade personliga brev från första halvan av 1900-talet skrivna av manliga författare från Marocko och Tunisien. Studiens övergripande syfte är att undersöka och identifiera de publicerade brevens litterära egenskaper (genius) och estetiska autonomi (egenvärde) med hjälp av en narratologisk och stilistisk metod som fokuserar påintertextualitet och This dissertation deals with a corpus of published private letters from the first half of the 20th century written by male writers from Morocco and Tunisia. The overall purpose of the study is to investigate and identify the literary properties (literary genius) of the published letters and their aesthetic autonomy using a stylistic and narratological method that focuses on intertextuality and the
The case presents Aboke-pesa, a local complementary currency in a poor rural area of Western Kenya.The reader gets an insight into the economic context of rural areas in the Global South, the work of introducing digital community currencies through farmers’ cooperatives, one of the most common designs of these currencies (mutual credit systems or LETS) as well as the particular challenges digital
A note with instructions for teaching the case with the same title.
Allergic contact dermatitis is reported among individuals using continuous glucose monitoring systems and insulin pumps. The aim of this study was to describe contact allergy patterns for allergens in the Swedish baseline series and medical device-related allergens among users. Contact allergy to baseline series allergens and isobornyl acrylate was compared between diabetes patients and dermatitis
Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from erythrocytes. Increased arginase activity leads to reduced arginine, as it is converted to urea and ornithine, and thereby reduced nitric oxide bioavailability, with secondary vascular injury. In this study we investigated arginase release in HUS patients and laboratory models
Aim: How the ability of plants to move towards newly favourable habitats (dispersal limitation) impacts the change of biome distribution and transition under fast climate warming is still debated. Analysing vegetation change in the past may help to clarify the relative importance of underlying ecological processes such as climate, biotic interactions, and dispersal. In this study, we investigated
Syftet med detta bidrag är alltså att kritiskt granska äldres rätt till fri rörlighetinom EU. Utgångspunkten för denna analys är artikel 3 FEU där centralavärden för EU såsom välfärd, fri rörlighet, icke-diskriminering, socialrättvisa, socialt skydd och jämställdhet mellan kvinnor och män betonas.Vårt bidrag i detta kapitel är att visa att såsom reglerna är utformade idagriskerar de att ha en kraf
