Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal and gastric (EG) adenocarcinoma. The aim of this st

Control systems can show robustness to many events, like disturbances and model inaccuracies. It is natural to speculate that they are also robust to sporadic deadline misses when implemented as digital tasks on an embedded platform. This paper proposes a comprehensive stability analysis for control systems subject to deadline misses, leveraging a new formulation to describe the patterns experienc

Weakly-hard models have been used to analyse real-time systems subject to patterns of deadline hits and misses. However, the tools that are available in the literature have a set of shortcomings. The analysis they offer is limited to a single weaklyhard constraint and to patterns that specify the number of misses, rather than the number of hits. Furthermore, the scalability of the tools is limited

The policy used to implement a control algorithm in a real-time system can significantly affect the quality of control. In this paper, we present a method to adapt the controller implementation, with the objective to improve the system’s performance under real-time faults. Our method compensates for missing state updates by adapting the controller parameters according to the number of consecutivel

Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloid precursor protein (APP) can affect synapses remains unclear. Interestingly, early hyperexcitability has been described in human AD and mouse models of AD

Background: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were i

Recension av Hans Christner (red.) Marinmålarna. Havet, skeppet och sjömannen i konsten från Jacob Hägg till Lars Lerin. Historiska Media / Sjöhistorisk Årsbok 2020-2021

Recension av Bengt Lindroth, Vi som inte var med i kriget. Om Sverige, Norden, Europa och coronan.

Cyclin dependent kinase 1 (CDK1) has long been known to drive the cell cycle and to regulate the division and differentiation of cells. Apart from its role in mitosis regulation, it also exerts multiple functions as a protein kinase, including engagement in cell death, possibly via a cell cycle-independent mechanism. The latter is suggested, since CDK1 re-expression can be found in non-dividing an

OBJECTIVES: Substandard and falsified medical products are, according to the World Health Organization, a global threat to public health. To evaluate if community pharmacy employees can guide the public to safer medication purchases, their knowledge and experience about SF medical products was examined.METHODS: A digital questionnaire was distributed to the five dominating pharmacy companies in Sw

Industrial relations vary between European countries. For member countries of the European union, the role of European legislation, labour law and other policy measures play a central and co-ordinating role. The current policy development from the European Commission on minimum wages illustrates the tensions between on one hand the Nordic model with collective agreements and a stronger role from s

The aim of this work was to evaluate the capability of diffuse reflectance spectroscopy to distinguish malignant liver tissues from surrounding tissues, and to determine whether an extended wavelength range (450–1550 nm) offers any advantages over using the conventional wavelength range. Furthermore, multivariate analysis combined with a machine learning algorithm, either linear discriminant analy

Jerk, the derivative of acceleration with respect to time, is a physical concept of great practical significance. However, this concept is rarely mentioned in textbooks and is often neglected in physics education. This paper describes how the concept of jerk can be easily introduced in the study of the dynamics of falling bodies, which are significantly affected by air resistance. In this regard,

This study examines the ways in which Web2.0 sociotechnical affordances of far-right metapolitics are gendered. Specifically, I focus on a key Swedish far-right entity that is not only an extensive publisher of far-right intellectual output, but also organizes a political salon that unites various actors from the European transnational far-right ecosystem. My explicit interests are in the performa

Ciguatera Poisoning (CP) is caused by consumption of fish or invertebrates contaminated with ciguatoxins (CTXs). Presently CP is a public concern in some temperate regions, such as Macaronesia (North‐Eastern Atlantic Ocean). Toxicity analysis was performed to characterize the fish species that can accumulate CTXs and improve understanding of the ciguatera risk in this area. For that, seventeen fis

Over the last decade, knowledge has significantly increased on the taxonomic identity and distribution of dinoflagellates of the genera Gambierdiscus and Fukuyoa. Additionally, a number of hitherto unknown bioactive metabolites have been described, while the role of these compounds in ciguatera poisoning (CP) remains to be clarified. Ciguatoxins and maitotoxins are very toxic compounds produced by

In the last decade, several outbreaks of ciguatera fish poisoning (CFP) have been reported in the Canary Islands (central northeast Atlantic Ocean), confirming ciguatera as an emerging alimentary risk in this region. Five Gambierdiscus species, G. australes, G. excentricus, G. silvae, G. carolinianus and G. caribaeus, have been detected in macrophytes from this area and are known to produce the ci