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Characteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants
Characterization and adaptation of Caldicellulosiruptor strains to higher sugar concentrations, targeting enhanced hydrogen production from lignocellulosic hydrolysates
The members of the genus Caldicellulosiruptor have the potential for future integration into a biorefinery system due to their capacity to generate hydrogen close to the theoretical limit of 4 mol H2/mol hexose, use a wide range of sugars and can grow on numerous lignocellulose hydrolysates. However, members of this genus are unable to survive in high sugar concentrations, limiting their ability t
Changeability and agility enablers in one-of-a-kind product development and design processes
The smart factories that are already beginning to appear employ a completely new approach to product creation. Smart products are uniquely identifiable and know both their current status and alternative routes to achieving their target state. Smart factories allow individual customer requirements to be met, meaning that even one-off items can be manufactured profitably. In smart industry, dynamic
Artificial intelligence enabled radio propagation for communications – Part I: Channel characterization and antenna-channel optimization
To provide higher data rates, as well as better coverage, cost efficiency, security, adaptability, and scalability, the 5G and beyond 5G networks are developed with various artificial intelligence techniques. In this two-part paper, we investigatethe application of artificial intelligence (AI) and in particular machine learning (ML) to the study of wireless propagation channels. It firstly provides a
Evaluation of protein and amino acid intake estimates from the EPIC dietary questionnaires and 24-h dietary recalls using different food composition databases
BACKGROUND AND AIMS: This study aimed to expand the European Prospective Investigation into Cancer and Nutrition (EPIC) nutrient database (ENDB) by adding amino acid (AA) values, using the U.S. nutrient database (USNDB). Additionally, we aimed to evaluate these new protein and AA intake estimates from the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR) using different matching p
Leisure-time physical activities and the risk of cardiovascular mortality in the Malmö diet and Cancer study
BACKGROUND: The association between leisure-time physical activity and cardiovascular mortality has been previously studied, but few studies have focused on specific activities and intensities.METHODS: The association between different leisure-time physical activities and cardiovascular mortality was investigated among 25,876 individuals without diabetes or cardiovascular disease from the populati
Improving texture and microstructure homogeneity in high-purity ta sheets by warm cross rolling and annealing
The evolution of texture and microstructure uniformity in high-purity tantalum (Ta) sheets during 135◦ warm cross rolling (WCR) was analyzed in detail. X-ray diffraction suggested that relatively uniform ‘ideal’ deformation texture distribution across the thickness could be obtained from WCR, since more potential slip systems could be activated. Electron backscatter diffraction (EBSD) results indi
Anaeramoebae are a divergent lineage of eukaryotes that shed light on the transition from anaerobic mitochondria to hydrogenosomes
Discoveries of diverse microbial eukaryotes and their inclusion in comprehensive phylogenomic analyses have crucially re-shaped the eukaryotic tree of life in the 21st century.1 At the deepest level, eukaryotic diversity comprises 9-10 "supergroups." One of these supergroups, the Metamonada, is particularly important to our understanding of the evolutionary dynamics of eukaryotic cells, including
Block Copolymer Nanolithography for Sub-50 nm Structure Applications
När de kritiska mönsterdimensionerna för högteknologiska enheter fortsätter krympa och mönstertätheten fortsätter öka, behöver även litografin att gå i samma riktning. En lovande teknologi är sampolymerlitografi, som har en upplösning under 10 nm, en mönsterperiodicitet omkring 7-200 nm, och lätt kan skalas upp till större ytor till en låg kostnad. Användandet av sampolymerer där de ingående blockAs high technology device patterns are continuing to move towards decreasing critical dimensions and increasing pattern density, there is a need for lithography to move in the same direction. Block copolymer (BCP) lithography is a promising technique, which has single digit nanometer resolution, has a pattern periodicity of about 7-200 nm, and easily scales up to large area at a low cost. The use
Thermistor-based biosensing
In this review a universal thermistor-based biosensor system is described with examples from clinical chemistry, bioprocess monitoring and environmental control. The technique is based on the measurement of the small temperature changes associated with enzymatic reactions occurring in a microreactor with immobilized enzyme. The system has good operational stability and a sensitivity that permits m
Reality shifting: psychological features of an emergent online daydreaming culture
Reality shifting (RS) is a trendy mental activity that emerged abruptly following the flare-up of the COVID-19 pandemicin 2020 and seems to be practiced mainly by members of the post-millennial generation. RS, described as the experience ofbeing able to transcend one’s physical confines and visit alternate, mostly fictional, universes, is discussed by many on Internetplatforms. One RS forum boasts
Can the Single-Tax-Principle Justify Anti-Avoidance Rules? The Case of Corporate Income Tax
Haemoglobin and red blood cell reference intervals during infancy
OBJECTIVES: There is a need for updated haematological reference data in infancy. This study aimed to define intervals for haemoglobin and red blood cell biomarkers based on data from a large cohort of longitudinally followed Swedish infants. DESIGN: Longitudinal cohort study. SETTING: Two Swedish study centres. PARTICIPANTS: Three community-based populations including 442 presumably healthy infan
It's much more grey than black and white : clinical geneticists' views on the oversight of consumer genomics in Europe
Aim: Direct-to-consumer (DTC) genetic tests (GT) have created controversy regarding their risks and benefits. In view of recent regulatory developments, this article aims to explore the attitudes of European clinical geneticists toward the oversight of DTC GT. Materials & methods: Fifteen semi-structured interviews were performed with clinical geneticists based in ten European countries. The t
A response to the forensic genetics policy initiative's report "Establishing Best Practice for Forensic DNA Databases"
How to responsibly acknowledge research work in the era of big data and biobanks : ethical aspects of the Bioresource Research Impact Factor (BRIF)
Currently, a great deal of biomedical research in fields such as epidemiology, clinical trials and genetics is reliant on vast amounts of biological and phenotypic information collected and assembled in biobanks. While many resources are being invested to ensure that comprehensive and well-organised biobanks are able to provide increased access to, and sharing of biomedical samples and information
Direct-to-consumer genetic testing : where and how does genetic counseling fit?
Direct-to-consumer genetic testing for disease ranges from well-validated diagnostic and predictive tests to 'research' results conferring increased risks. While being targeted at public curious about their health, they are also marketed for use in reproductive decision-making or management of disease. By virtue of being 'direct-to-consumer' much of this testing bypasses traditional healthcare sys
The challenges of the expanded availability of genomic information : an agenda-setting paper
Rapid advances in microarray and sequencing technologies are making genotyping and genome sequencing more affordable and readily available. There is an expectation that genomic sequencing technologies improve personalized diagnosis and personalized drug therapy. Concurrently, provision of direct-to-consumer genetic testing by commercial providers has enabled individuals' direct access to their gen
DeveLoP—A Rationale and Toolbox for Democratic Landscape Planning
A rationale for an individuals-oriented landscape approach to sustainable land-use planning based on an analysis of bio-geo-physical components as well as the human components of the landscape is presented. A toolbox for analysing individuals’ decision-making and valuations in the landscape is described. The toolbox can provide evidence on the drivers of individuals’ decision-making in the landsca