We have previously shown that leukotriene D(4) (LTD(4)), a known pro-inflammatory mediator, induces increased survival and proliferation of intestinal epithelial cells. In this study we examined whether LTD(4) functions via activation of the transcription factors NFkappaB and AP-1, which are potent inducers of mitogenesis. We found that the NFkappaB inhibitory protein IkappaBalpha was not degraded

This paper explores a formally grounded ap- proach to solve the problem of dynamic binding in service- oriented software architecture. Dynamic binding is a widely adopted mean to automatically bind exposed software interfaces to actual implementations. The execution of an operation on one or another implementation, though providing the same result, could turn out in different quality of service, e

Control allocation problems, in which optimal actuator values are assigned based on desired control actions and actuator constraints, are typically formulated as constrained optimization problems. Initially, only approximate solutions to the problems were deemed tractable for real-time applications. Recently however, active set algorithms have been identified as a means for solving control allocat

Electroconvulsive therapy (ECT) is an efficient and relatively fast acting treatment for depression. However, one severe side effect of the treatment is retrograde amnesia, which in certain cases can be long-term. The mechanisms behind the antidepressant effect and the amnesia are not well understood. We hypothesized that ECT causes transient downregulation of key molecules needed to stabilize syn

Syftet med artikeln är att utforska och förstå beskrivningar av och information om HPV-prevention utifrån olika positioner för att fånga samhälleliga och kulturella innebörder av HPV-vaccin. Två skolsköterskor intervjuades om sitt arbete med HPV-vaccinering, mediematerial om HPV-vaccin hämtades från Dagens Nyheter, Svenska Dagbladet och Sydsvenskans online-arkiv och informationsmaterial hämtades fThe aim of this article is to explore and understand information about HPV-prevention from several positions to grasp its social and cultural meanings. The material consists of interviews with two school nurses, material on HPV-vaccine from Swedish newspapers (Dagens Nyheter, Svenska Dagbladet, Sydsvenskan), and information from public authorities and pharmaceutical companies. In the analysis of t

Lipase has been encapsulated in ordered mesoporous materials in a one-step process. The procedure is simple and leads to well structured materials with enzyme loadings higher than those obtained through the post-synthesis approach. In the final bottle-around-the-ship material the enzyme would be entrapped in silica cages whose entrances are smaller than the enzyme itself. Therefore, reagents and p

Context. A number of large spectroscopic surveys of stars in the Milky Way are under way or are being planned. In this context it is important to discuss the extent to which elemental abundances can be used as discriminators between different (known and unknown) stellar populations in the Milky Way. Aims. We aim to establish the requirements in terms of precision in elemental abundances, as derive

Neuronal function depends on the properties of the synaptic inputs the neuron receive and on its intrinsic responsive properties. However, the conditions for synaptic integration and activation of intrinsic responses may to a large extent depend on the level of background synaptic input. In this respect, the deep cerebellar nuclear (DCN) neurons are of particular interest: they feature a massive b

Differential regulation as well as target gene specificity of the two hypoxia-inducible factor (HIF)-alpha subunits HIF-1alpha and HIF-2alpha in various tumors and cell lines have been suggested. In breast cancer, the prognostic significance of HIF-1alpha is not clear-cut and that of HIF-2alpha is largely unknown. Using IHC analyses of HIF-1alpha, HIF-2alpha, and vascular endothelial growth factor

Recension av Anna Whitelock, Elisabet I. Historien om drottningen och hennes förtrogna

Increasing evidence on associations between mental health and chronic diseases like cardio-vascular disease and diabetes together with the fact that little is known about the prevalence of anxiety/depression and associated risk factors among Iraqi immigrants to Sweden, warrants a study in this group. The aim was to study the prevalence of anxiety and depression in immigrants from Iraq compared to

The inclusive production cross sections at forward rapidity of , , (1S) and (2S) are measured in collisions at with the ALICE detector at the LHC. The analysis is based on a data sample corresponding to an integrated luminosity of 1.35 pb. Quarkonia are reconstructed in the dimuon-decay channel and the signal yields are evaluated by fitting the invariant mass distributions. The differential produc

Cellulose is insoluble in water and many organic solvents, but can be dissolved in a number of solvents of intermediate properties, like N-methylmorpholine N-oxide (NMMO) and ionic liquids (ILs). It can also be dissolved in water at high and low pHs, in particular if a cosolute of intermediate polarity is added. The insolubility in water is often referred to strong intermolecular hydrogen bonding

The mechanism for the acid-mediated substitution of a phenolic hydroxyl group with a sulfur nucleophile has been investigated by a combination of experimental and theoretical methods. We conclude that the mechanism is distinctively different in nonpolar solvents (i.e., toluene) compared with polar solvents. The cationic mechanism, proposed for the reaction in polar solvents, is not feasible and th

Objective: To investigate the association between total serum cholesterol (TSC) and cancer incidence in the Metabolic syndrome and Cancer project (Me-Can). Methods: Me-Can consists of seven cohorts from Norway, Austria, and Sweden including 289,273 male and 288,057 female participants prospectively followed up for cancer incidence (n = 38,978) with a mean follow-up of 11.7 years. Cox regression mo

Background: Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR hav

The most serious risk connected with transplantations besides infection is graft rejection. Organ transplant recipients (OTRs) perceive graft rejection as a stress factor and a threat. The primary aim of the present study was to examine types of coping used to handle the threat of the risk of graft rejection among OTRs and to investigate relations between coping and perceived threat as well as Hea

The present paper shows the validation of a self tuning heat release method with no need to model heat losses, crevice losses and blow by. Using the pressure and volume traces the method estimates the polytropic exponents (before, during and after the combustion event), by the use of the emission values and amount of fuel injected per cycle the algorithm calculates the total heat release. These fo