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Partial correction of anemia in patients with chronic kidney disease (CKD) reduces left ventricular hypertrophy (LVH), which is a risk factor for cardiovascular (CV) morbidity, but complete correction of anemia does not improve CV outcomes. Whether LV geometry associates with CV events in patients who are treated to different hemoglobin (Hb) targets is unknown. One of the larger trials to study th
Abstract in UndeterminedThe MAX IV facility presently under construction will include two storage rings for the production of synchrotron radiation. Both rings will be operated at a constant 500 mA of stored current with top-up shots supplied by the MAX IV linac acting as a full-energy injector. Until recently, injection into both storage rings was designed using a conventional approach: a closed
A decade has passed since the first human embryonic stem cell (hESC) line was established, providing immense hope in curing diseases by cell replacement therapy. For instance, in the pancreas, the insulin-producing β-cells are damaged in diabetes patients, and a successful replacement of those cells could provide a cure. These cells can be replaced by organ donation, but owing to a profound scarci
BACKGROUND: Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described, e.g. tumours, particularly pituitary adenomas, malformations, and infections/inflammations. The evaluation of cluster headache is an issue unresolved. CASE DESCRIPTION: We present a case of a 43-year-old patient who presented with
Background: Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family Cancer Database to further analyze these effects. Methods: We selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth orde
The neutron partial decay width of one-particle resonant levels that are the bandhead states in odd-N deformed nuclei is estimated in the formalism with a real-energy variable, using the width of one-particle resonance calculated in terms of eigenphase. It is shown that because of the presence of various (lj) components in a given one-particle resonant level of deformed nuclei, the neutron decay w
Deoxyribonucleotides are the building blocks of DNA and can be synthesized via de novo and salvage pathways. Deoxyribonucleoside kinases (dNKs) salvage deoxyribonucleosides by transfer of a phosphate group to the 5' of a deoxyribonucleoside. This salvage pathway is well characterized in mammals but in contrast little is known about how plants salvage deoxyribonucleosides. We show that during salva
Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and barley. Similar to other autoimmune diseases such as type 1 diabetes, psoriasis and rheumatoid arthritis, celiac disease is the result of an immune response to self-antigens leading to tissue destruction and production of autoantibodies. Common d
Are voiceless approximants categorically distinct from voiceless fricatives? We address this question by means of acoustic analysis of voiceless laterals in Icelandic, Welsh, and the endangered variety Estonian Swedish. All three have a voiceless lateral functioning in contrast to a voiced lateral approximant. The analysis focused on duration – including any period of voicing (‘pre-voicing’) just
This report analyses the technical opportunities for a complete decarbonisation of the basic material industry in Sweden by 2050. From this assessment, the report discusses policy implications for the industry sector given the overall framework set by the ongoing international climate negotiations. Relying on current production systems and applying “end-of-pipe” solutions will be insufficient to
We present a polynomial time dynamic programming algorithm for optimal partitions in the shortest path metric induced by a tree. This resolves, among other things, the exact complexity status of the optimal partition problems in one-dimensional geometric metric settings. Our method of solution could be also of independent interest in other applications. We discuss also an extension of our method t
We demonstrate the extent to which modern detector technology, coupled with a high flux constant wavelength neutron source, can be used to obtain high quality diffraction data from short data collections, allowing the refinement of the full structures (including hydrogen positions) of hydrous compounds from in situ neutron powder diffraction measurements. The in situ thermodiffractometry and contr
Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II in seminal fluid. PSA also cleaves several other substrates, which may explain its putative functions in prostate cancer and its antiangiogenic activit
The present work is based on the Kantian (AaO)-axiom and conceptualised as textbook. As scientific method in the true sense of the notion science, the Vertex version of Perspective Text Analysis represents a completely new approach to text-based studies. The core of Vertex is introduced by means of instructions to a stepwise procedure. The steps are richly illustrated. The inter-lingual character
A critical survey of scholarly work on Swedish Literature published in 2013.
Background: Multiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)1. The role of Stat1 in MM has not been elucidated, but Stat1 has in several studies been ascribed a
During blood-sucking, female members of the family Tabanidae transmit pathogens of serious diseases and annoy their host animals so strongly that they cannot graze, thus the health of the hosts is drastically reduced. Consequently, a tabanid-resistant coat with appropriate brightness, colour and pattern is advantageous for the host. Spotty coats are widespread among mammals, especially in cattle (
