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As gene therapy for haemophilia is now licensed in Europe, and the hub and spoke approach is widely promoted for its delivery and follow-up, it is essential that people with haemophilia (PwH) who are eligible and opt to have this treatment are enabled to obtain the maximum benefit. Ensuring the pathway that makes up the patient gene therapy journey is effective is key to achieving this. EAHAD and

This review deals with the production of oxygen by photo-oxidation of water, which is a topic fitting a journal devoted to oxygen. Most of the present biosphere, including mankind, depends on oxygen. Elucidating the mechanism is of importance for solving the present energy crisis. Photosynthesis evolved in bacteria, first in a form that did not produce oxygen. The oxygen-producing version arose wi

IMPORTANCE: Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney function. This decreases the utility of FLC testing in the clinical evaluation and follow-up of plasma cell disorders, particularly affecting the diagnosis of

OBJECTIVES: Short time to positivity (TTP) has been proposed as a prognostic indicator in bloodstream infection (BSI) but results have been conflicting. The aim of this study was to explore the association between TTP and disease severity, using non-linear models.METHODS: This population-based retrospective study included all blood cultures in southern Sweden from 2021 to 2023. Using healthcare da

Introduction: Some children may witness their grandparents or great-grandparents spending their final days in a nursing home, while others have peers with older relatives living in nursing homes. Children learn about ageing through experience and exposure, where picture books can also shape their perceptions and attitudes toward older adults residing in nursing homes.Aim: To explore the underlying

After a long period of being constructed as anonymous administration complexes, first instance courts are once again being built as emblematic elements of the city, designed by renowned architects and rising up on central plots adjacent to train stations, headquarter buildings and exclusive residential areas. This is happening at a time of centralisation, upsizing and property privatisation, and w

Isoprene is a reactive hydrocarbon emitted to the atmosphere in large quantities by terrestrial vegetation. Annual total isoprene emissions exceed 300 Tg a−1, but emission rates vary widely among plant species and are sensitive to meteorological and environmental conditions including temperature, sunlight, and soil moisture. Due to its high reactivity, isoprene has a large impact on air quality an

Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl

This study analyzes the transition to mechanized forest management and the implementation of sustainable-yields forestry in Sweden during the 1950s and 1960s. The objective is to produce insights that are relevantfor policymakers working with forests and the climate transition today. The analysis focuses on how the Swedish National Association of Forest Owners’ Associations (SSR)—an association or

Abstract in French:L’article examine les dix fables en prose que l’auteur suédois August Strindberg a écrites en français pendant les années 1880. L’analyse se concentrera sur trois aspects de ces textes : le contexte de leur création et publication, leur statut générique et la vision qu’ils véhiculent sur la relation entre l’être humain et son animalité. L’article montre que Strindberg a renouvelL’article examine les dix fables en prose que l’auteur suédois August Strindberg a écrites en français pendant les années 1880. L’analyse se concentrera sur trois aspects de ces textes: le contexte de leur création et publication, leur statut générique et la vision qu’ils véhiculent sur la relation entre l’être humain et son animalité. L’article montre que Strindberg a renouvelé le genre de la fab

From the chapter "Introduction and Background": The pilot phase of the National Urban Policy Programme (NUPP): “Developing NUP and Smart City Strategies in Iran” started in 2017 in collaboration between UN-Habitat, Republic of Korea, in three pilot countries of Niger, Myanmar, and Islamic Republic of Iran. It aimed to develop National Urban Policies and Smart City Strategies in Iran and to offer a

The Gullåkra wetland is located around 5 km south of the modern city of Lund and around 2.7 km east of the important Iron Age settlement of Uppåkra in Scania, southern Sweden. In the 1840s, a remarkable discovery was made in the wetland: a bronze lur dated to c. 1300 BCE, along with a boat and the bones of a large animal offering. As Bronze Age boats are exceedingly rare, this discovery makes the

A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated

Previous research suggests a pattern of gaze avoidance in East Asian compared with Western cultures. Yet, recent eye-tracking studies of face-to-face conversation do not corroborate this. More generally, differences in nonverbal communication and analytic versus holistic strategies have been described between East Asian and Western cultures. Using wearable eye-tracking technology and an automated

We explore the transformative potential of SAM 2, a vision foundation model, in advancing gaze estimation. SAM 2 addresses key challenges in gaze estimation by significantly reducing annotation time, simplifying deployment, and enhancing segmentation accuracy. Utilizing its zero-shot capabilities with minimal user input—a single click per video—we tested SAM 2 on over 14 million eye images from a

This article investigates how social media can enable and constrain civil society organizations’ (CSOs) discharge of accountability. Based on a comparative analysis of the Instagram, Facebook, and Twitter (X) posts of the Swedish Red Cross during 1 year (N = 1014), we propose a framework of affordances that illustrate how platform features, practices, norms, and perceptions about audiences jointly

The modern food industry faces the challenge of catering to diverse consumer preferences while maintaining efficiency and profitability. Rapid shifts in consumer trends, emerging technologies, and evolving regulations make it difficult for companies to keep pace, often resulting in inefficiencies and lost opportunities. The vast amount of data generated across production, supply chains, and market