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This thesis addresses challenges in increasing the robustness of cloud-deployed applications and services to unexpected events and dynamic workloads. Without precautions, hardware failures and unpredictable large traffic variations can quickly degrade the performance of an application due to mismatch between provisioned resources and capacity needs. Similarly, disasters, such as power outages and
This paper investigates the potential of an infant intervention to improve life expectancy, contributing to emerging interest in the early life origins of chronic disease. We track individuals from birth to death, and are able to identify age and cause of death. The intervention was pioneered in Sweden in 1931–1933, and appears to have been pivotal in the emergence of universal infant care program
Determining structures of membrane proteins remains a significant challenge. A technique utilizing high lipid-detergent concentrations ("HiLiDe") circumvents the major bottlenecks of current membrane protein crystallization methods. During HiLiDe, the protein-lipid-detergent ratio is varied in a controlled way in order to yield initial crystal hits, which may be subsequently optimized by variation
A 2.8-to-5.8 GHz harmonic VCO designed in a 28 nm UTBB FD-SOI CMOS process adopts a reconfigurable active core to save power at the lower oscillation frequencies, and to enable a trade-off between power consumption and phase noise at all frequencies. Interference caused by the magnetic coupling to and from the VCO inductor is greatly attenuated by resorting to an inductor in the shape of an 8. Sim
A 2.8-to-5.8GHz VCO designed in a 28nm UTBB FD-SOI CMOS process adopts a reconfigurable active core to save power at the lower oscillation frequencies, and to enable a trade-off between power consumption and phase noise at all frequencies. The UTBB FD-SOI CMOS process is instrumental to achieve a tuning range in excess of one octave at low power consumption, while the use of an 8-shaped tank coil
A digital phase-locked loop (DPLL) which uses a high resolution 2-dimension gated-Vernier time-to-digital converter (TDC) is presented. The shaped Vernier quantization of TDC greatly improves the in-band phase noise. Also the 2-dimension structure makes DPLL be able to process large phase errors almost without the influence of latency time. Combined with a high figure-of-merit (FOM) class-D digita
This review explores recent findings on gross metabolic responses of vegetable tissue induced by the application of pulsed electric field as well as discusses potential industrial applications of reversible electroporation./Este artículo explora recientes investigaciones sobre respuestas metabólicas de tejidos vegetales inducidas por la aplicación de pulsos eléctricos. También se dis
Empirical software engineering is a growing research area. Industrial experience gathered by systematic empirical case studies is extremely important for further evolution of the software engineering discipline. Scientific theory cannot provide effective means for software industry without fundamental understanding of the evolutionary development of complex software systems. However, there are cer
Fresh-cut fruit and vegetable are minimally processed products that have to maintain their quality (appearance, texture, flavour and nutritive value) similar to those of the fresh product. The fundamental principle underlying the quality of these commodities is that they are metabolic active tissues and, as a consequence, show physiological response to preparation procedures as well as to the envi
Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that
Vacuum impregnation (VI) has been widely utilized as a pre-treatment method prior to, e.g., the minimal processing, freezing, or drying of foods. In many cases, VI has been used to focus on the enrichment of fruits and vegetables with probiotics or micronutrients, texture enhancement, the modification of the sensory attributes, and extension of shelf life by pH reduction. However, little attention
Background In this study, the long term effects of ECT on patients with depression were investigated through repeated rCBF and EEG measures as well as clinical characteristics over several years. The aim of the investigation was to establish an association with the eventual development of dementia. Method A cohort of forty-nine patients (21 men and 28 women) with a mean age of 61 years underwent E
Vacuum impregnation is used in the food industry to facilitate the impregnation of porous products with, e.g. firming, antioxidant, antimicrobial or cryoprotective agents. X-ray micro-tomography (μCT) was used to study the process of vacuum impregnation in spinach leaves. Low (300 mbar absolute pressure) and mild vacuum (150 mbar absolute pressure) impregnation protocols were used to impregnate an
This study compares the time required to activate a grasp or function of a hand prosthesis when using an electromyogram (EMG) based control scheme and when using a control scheme combining EMG and control signals from an inductive tongue control system (ITCS). Using a cross-over study design, 10 able-bodied subjects used a computer model of a hand and completed simulated grasping exercises. The ti
The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8αβ+ and CD4+CD8αα+ T cells; the latter requiring β8 integrin expression by migratory IRF8 depend
