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Large cardiac rhabdomyomas can disturb hemodynamic flow. Tuberous sclerosis complex is the most common cause of cardiac rhabdomyoma in fetuses. Recently, a mammalian target of rapamycin (mTOR) inhibitor effectively treated rhabdomyomas associated with tuberous sclerosis. Here, we report the effectiveness of an mTOR inhibitor in treating a fetus with large rhabdomyomas exhibiting severe heart failu

Trimetallic nickel–iron–molybdenum oxides are excellent electrocatalysts for alkaline water electrolysis despite experiencing severe molybdenum dissolution. While the impact of molybdenum on fresh samples is well-understood, its substantial loss during operation without compromising performance presents a unique puzzle. Here, we show that the initial presence of molybdenum induces the formation of

We reviewed papers on optimal conjunctive use of surface and groundwater (GW) with application in dry regions. Selected papers from the last 25-year period were reviewed using the PRISMA method. We show that with increasing scarcity of water, objectives of models developed for optimal conjunctive use have become more environmentally and socially oriented. About two-thirds of the studies are dedica

This paper investigates the magnitude and drivers of ethnic and religious disparities in Female Labor Force Participation (FLFP) in Syria. Using census data and the Gelbach decomposition method, the analysis reveals substantial FLFP gaps across groups, reaching up to 18 percentage points. To understand the factors underlying these gaps, the analysis exploits the heterogeneity in economic developme

By combining ultrashort laser pulses with PEEM, time-resolved photoemission electron microscopy (TRPEEM) provides a powerful approach for investigating ultrafast charge carrier dynamics with simultaneous femtosecond temporal resolution and nanometer spatial precision. It has evolved into a versatile methodto study a wide range of phenomena, including charge carrier dynamics, surface plasmons, scat

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BACKGROUND: Cluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain accompanied by trigemino-autonomic signs, which significantly impacts the quality of life, social interactions, and occupational functioning of those who are affected. To promote a better understanding of this disabling condition and to foster research

Under 2022 och 2023 ökade livsmedelspriserna kraftigt. Även energipriserna steg kraftigt under 2022. För att motverka den stigande inflationen höjde Riksbanken styrräntan. Sammantaget medförde det betydande kostnadsökningar för de svenska hushållen. I detta projekt har vi studerat hur prisökningarna har påverkat livsmedelsförsäljningen inom detaljhandeln och kostintaget på befolkningsnivå. Analyse

Tumor associated neutrophils (TANs) exert dual and opposing functions in tumors, acting pro-tumorigenic and anti-tumorigenic, depending on tumor progression, polarization state and subtype. Consequently, the prognostic impact of TANs in breast cancer is also contradictory. Since neutrophils are critically needed to fight infections in cancer patients, the mediators leading to tumor progression nee

Oxy-fuel combustion is regarded as an underpinning technology for carbon capture and utilization. Ethane (C2H6) is the primary non-methane component in natural gas and a fundamental C2 fuel. In this work, laminar burning velocities (LBV) of C2H6/O2/CO2 mixtures were measured using the heat flux method at atmospheric pressure, spanning initial temperatures of 308–348 K, equivalence ratios of 0.6–1.

Background: Knee replacement (KR) is the most common osteoarthritis (OA) related surgery. Studies suggest that there are major international and national disparities in pre-operative information, support and access to rehabilitation which have a substantial impact on patients’ perceived outcomes of the KR. The aim of this qualitative study was to explore experiences and perceptions of the care pat

Background: Tumor immune cell infiltration is a favorable prognostic factor in triple-negative breast cancer. Most triple-negative tumors belong to the aggressive basal-like subtype. We hypothesized that immune gene expression may identify low-risk patients for whom adjuvant chemotherapy can be de-escalated. Methods: The expression of 753 immune-related genes was analyzed in tumor biopsies from 45

Background: Microscopic colitis (MC) is characterized by non-bloody, watery diarrhea predominantly in elderly women. Known risk factors are smoking, medication with NSAIDs, PPIs or SSRIs, while data on hormonal factors is sparse. The aim of the present study was to investigate whether hormonal factors that disrupt the sex hormonal balance could have an impact on the disease course in MC. Methods:

Background: The aim of this study was to develop a method for personalized training of Deep Neural Networks by means of an MRI simulator to improve MOLLI native T1 estimates relative to conventional fitting methods. Methods: The proposed Personalized Training Neural Network (PTNN) for T1 mapping was based on a neural network which was trained with simulated MOLLI signals generated for each individ

Animal research show that a novel exploration task performed shortly before a learning episode can strengthen hippocampal memory consolidation through behavioural tagging mechanisms. The aim of the present study was to conceptually translate behavioural tagging results to humans using a novel exploration task in virtual reality. Mimicking conditions for animal research, sixty participants underwen

Frameshifts can be caused by specific combinations of tRNA and mRNA. The wildtype AGC-decoding E. coli tRNASer3GCU has been shown to induce −1 ribosomal frameshifting on GCA alanine codons, and proposed to read a two-base codon instead of a canonical triplet. However, it has remained unclear whether this type of non-cognate decoding can be accommodated by the ribosome. Here, we perform single-part

Background: The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. Methods: This was a post hoc analysis of the TTM2-trial,

We report on the commissioning of an ultrafast timing diagnostic for measuring a time-offset signal between two different synchronized ultrashort light pulses. The method is based on sum-frequency generation in a nonlinear crystal. The setup is similar to an auto/cross-correlator setup. In this case, one of the beams is a relatively weak diagnostic beam of visible light from a bending magnet at Fe