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Up to 20 percent of Swedish couples have difficulty having children. Now a new research project will seek to find the answer to the riddle of infertility. In a group effort to combat involuntary childlessness, researchers within the Öresund collaboration ReproUnion are creating a register that includes 5,000 Swedish and Danish childless couples. The biobank is named ReproUnion Biobank and Infertil

https://www.medicine.lu.se/article/reprounion-joins-forces-combat-involuntary-childlessness-creating-biobank - 2025-10-19

Lund University has recruited Trevor Forsyth to lead the development of LINXS, Lund Institute of advanced Neutron and X-ray Science. He also takes up the position as professor of biophysics at the Faculty of Medicine. This strategic recruitment is part of Lund University's efforts to develop new research using neutron and synchrotron light techniques - and is an important step to maximise the pote

https://www.medicine.lu.se/article/top-international-researcher-will-maximise-potential-max-iv-and-ess - 2025-10-19

Europe's largest respiratory society, ERS, has awarded its winners for 2021. By doing so the society wishes to recognise the achievements of leaders in the field of respiratory medicine. The Mid-Career Gold Medal in Asthma for 2021 went to EMV´s own Lena Uller, Professor in Immunology. It´s a very prestigious award! Warm congrats, Lena! ­– Thank you so much, I feel overwhelmed. Especially now afte

https://www.medicine.lu.se/article/european-gold-medal-respiratory-medicine-awarded-professor-lund - 2025-10-19

Children who had autoantibodies before falling ill with type 1 diabetes have also had an imbalance in their intestinal flora, previous research shows. In a new study conducted within the framework of a European research network, researchers at Lund University and Region Skåne will investigate whether the ingestion of probiotics from early birth can prevent the development of type 1 diabetes in chi

https://www.medicine.lu.se/article/new-study-can-probiotics-prevent-type-1-diabetes - 2025-10-19

Congratulations, Katarina Steding-Ehrenborg, Docent at Lund University! You’re one of six sports researchers who will take part in a two-year development program in which the Swedish Olympic Committee is now investing. What will the investment mean for you? – The support from the SOC means that we can carry out long-term studies on how strenuous exercise affects the heart and thus help make sports

https://www.medicine.lu.se/article/lund-researcher-joins-olympic-offensive - 2025-10-19

During September and October, schoolchildren, seniors and other interested parties are examining the obstacles that exist in Swedish housing. Their tools in this work are a ruler and a mobile app. The Housing Experiment (Bostadsförsöket) research project is a collaboration between the ForskarFredag science festival and researchers at Lund University. *This is a press release originally sent from V

https://www.medicine.lu.se/article/help-researchers-measure-your-home - 2025-10-19

New population study from Lund University Risk of bladder cancer by disease severity in relation to metabolic factors and smoking; a prospective pooled cohort study of 800,000 men and womenPrevious studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor invasiveness. Among 811 63

https://www.lupop.lu.se/article/risk-bladder-cancer-disease-severity-relation-metabolic-factors-and-smoking - 2025-10-19

Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use in the field of pain. R

https://www.lupop.lu.se/article/perspectives-pain-registries - 2025-10-19

Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality ratio or hazard ratio to

https://www.lupop.lu.se/article/translating-all-cause-mortality-rate-ratios-or-hazard-ratios-age-longevity-and-probability-based - 2025-10-19

Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. The twister plot is a −9

https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2025-10-19

Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in some way to the constr

https://www.lupop.lu.se/article/constructed-measures-and-causal-inference-towards-new-model-measurement-psychosocial-constructs - 2025-10-19

Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and interpretations are un

https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2025-10-19

Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compare statistical methods

https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2025-10-19

The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing participants with non-

https://www.lupop.lu.se/article/cohort-profile-and-representativeness-participants-diet-cancer-and-health-next-generations-cohort - 2025-10-19

Karin Larsson's presentation from the GIS seminar is now available Read more here.

https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2025-10-19

Recruiting participants to a clinical study is a resource-intensive process with a high failure rate. The Scottish Health Research Register (SHARE) provides recruitment support service which helps researchers recruit participants by searching patients’ Electronic Health Records (EHRs). The current study aims to evaluate the performance of SHARE in participant recruitment. Read the paper at https:/

https://www.lupop.lu.se/article/early-experience-opt-research-register-scottish-health-research-register-share-multi-method - 2025-10-19

Modern artificial intelligence techniques have solved some previously intractable problems and produced impressive results in selected medical domains. One of their drawbacks is that they often need very large amounts of data. Pre-existing datasets in the form of national cancer registries, image/genetic depositories and clinical datasets already exist and have been used for research. In theory, t

https://www.lupop.lu.se/article/registries-databases-and-repositories-developing-artificial-intelligence-cancer-care - 2025-10-19

Background: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time. Patients and Methods: We extracted systemic anticancer treatment procedures from the Danish Nati

https://www.lupop.lu.se/article/high-validity-danish-national-patient-registry-systemic-anticancer-treatment-registration-2009-2019 - 2025-10-19

The DMSKW is a valuable structure in providing safety data on drug exposure during pregnancy and lactation in combination with information on disease activity up to 6 years postpartum. This article will be the reference for describing the methods of future publications from the DMSKW. Read the paper at https://journals.sagepub.com/doi/10.1177/17562864211054956

https://www.lupop.lu.se/article/german-multiple-sclerosis-and-pregnancy-registry-rationale-objective-design-and-first-results - 2025-10-19

Sibling comparison studies have the attractive feature of being able to control for unmeasured confounding by factors that are shared within families. However, there is sometimes a concern that these studies may have poor generalizability (external validity) due to the implicit restriction to families that are covariate-discordant, i.e., those families where at least two siblings have different le

https://www.lupop.lu.se/article/generalizability-and-effect-measure-modification-sibling-comparison-studies - 2025-10-19