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The Importance of Reference Centers and Registries for Rare Diseases: The Example of Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin deficiency (AATD) is a rare and underdiagnosed disease that is associated with the development of liver disease in adults and children and pulmonary emphysema in adults. Several studies have shown that there is limited knowledge about the disease and its diagnosis among health care providers, and there is an important inequity in the access to specialized care and appropriate t

https://www.lupop.lu.se/article/importance-reference-centers-and-registries-rare-diseases-example-alpha-1-antitrypsin-deficiency - 2025-10-19

Effects of pay-for-performance on prescription of hypertension drugs among public and private primary care providers in Sweden

This study exploits policy reforms in Swedish primary care to examine the effect of pay-for-performance (P4P) on compliance with hypertension drug guidelines among public and private health care providers. Using provider-level outcome data for 2005–2013 from the Swedish Prescription Register, providers in regions using P4P were compared to providers in other regions in a difference-in-differences

https://www.lupop.lu.se/article/effects-pay-performance-prescription-hypertension-drugs-among-public-and-private-primary-care - 2025-10-19

Effect of medical treatment in patients with systemic right ventricle

Congenitally corrected and surgical atrial redirected transposition of the great arteries (TGA) represents states where the morphological right ventricle serves as a systemic ventricle (S-RV). The S-RV is prone to failure, but data on medical treatment on this problem is limited. The purpose of this study was to evaluate the survival in adults with S-RV, with or without heart failure treatment. De

https://www.lupop.lu.se/article/effect-medical-treatment-patients-systemic-right-ventricle - 2025-10-19

Personal History of Diabetes as Important as Family History of Colorectal Cancer for Risk of Colorectal Cancer: A Nationwide Cohort Study

Diabetes mellitus (DM) and colorectal cancer (CRC) share some risk factors, including lifestyle and metabolic disturbances. We aimed to provide in-depth information on the association of CRC risk, especially early-onset CRC, with DM, family history of CRC, and age at DM diagnosis. Read more at https://journals.lww.com/ajg/Fulltext/2020/07000/Personal_History_of_Diabetes_as_Important_as.24.aspx

https://www.lupop.lu.se/article/personal-history-diabetes-important-family-history-colorectal-cancer-risk-colorectal-cancer - 2025-10-19

Prediction of Life Satisfaction in People with Parkinson’s Disease

People with Parkinson’s disease (PD) have lower life satisfaction (LS) than healthy peers. No study has yet identified predictors of LS in people with PD. Such information would be valuable for health care and future interventions that aim to maintain or increase LS. Read more at https://www.hindawi.com/journals/pd/2020/1561037/

https://www.lupop.lu.se/article/prediction-life-satisfaction-people-parkinsons-disease - 2025-10-19

New calls for proposal at VR

Eight new calls for proposal are now open The Swedish Research Council has now opened several calls for proposals within Natural and engineering sciences, Educational sciences and Development research. Most of the calls are open until 10 April, but the Network grant within Educational Sciences is open until 27 March.Read more at www.vr.se.

https://www.lupop.lu.se/article/new-calls-proposal-vr - 2025-10-19

Mortality and morbidity of low-grade red blood cell transfusions in septic patients: a propensity score-matched observational study of a liberal transfusion strategy

Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but based on previous randomized controlled trials and observational studies, there are still uncertainties about the safety in giving low-grade RBC transfusions to patients with sepsis. Read mo

https://www.lupop.lu.se/article/mortality-and-morbidity-low-grade-red-blood-cell-transfusions-septic-patients-propensity-score - 2025-10-19

Predictive Factors for Postoperative Pancreatic Fistula—A Swedish Nationwide Register-Based Study

Data from the Swedish National Registry for Pancreatic and Periampullary Cancer for all patients undergoing a PD from 2010 until 30th June 2018 were collected. The material was analysed in two groups, no POPF and clinically relevant (grade B and C) POPF. Read more at https://link.springer.com/article/10.1007/s00268-020-05735-4

https://www.lupop.lu.se/article/predictive-factors-postoperative-pancreatic-fistula-swedish-nationwide-register-based-study - 2025-10-19

Occurrence of cold sensitivity in carpal tunnel syndrome and its effects on surgical outcome following open carpal tunnel release

Cold sensitivity is common following nerve injuries in the upper extremity, but is less well studied in carpal tunnel syndrome (CTS). We investigated cold sensitivity in CTS and its effects on surgical outcome. A search of the Swedish National Registry for Hand Surgery (HAKIR) for open carpal tunnel releases (OCTR) from 2010–2016 identified 10,746 cases. Symptom severity questionnaires (HQ-8; HAKI

https://www.lupop.lu.se/article/occurrence-cold-sensitivity-carpal-tunnel-syndrome-and-its-effects-surgical-outcome-following-open - 2025-10-19

Cognitive test results are associated with mortality and rehospitalization in heart failure: Swedish prospective cohort study

Two hundred and eighty‐one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making Test A, and Symbol Digit Modalities Test. The mean follow‐up time censored at rehospitalization or death was 13 months (interquartile range, 14) and 28 months (interquartile range, 29), respe

https://www.lupop.lu.se/article/cognitive-test-results-are-associated-mortality-and-rehospitalization-heart-failure-swedish - 2025-10-19

Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data

Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Read more at https://journals.sagep

https://www.lupop.lu.se/article/disentangling-social-genetic-rearing-environment-effects-alcohol-use-disorder-using-swedish-national - 2025-10-19

Early versus late initiation of GH replacement in adult-onset hypopituitarism

Adult-onset growth hormone deficiency (AGHD) is usually the last deficiency to be substituted in hypopituitarism. In children with documented GH deficiency, treatment without delay is crucial for achieving optimal effects on growth and development. In adults, it is not known whether a delay in treatment initiation influences biochemical response and the favourable physiological effects resulting f

https://www.lupop.lu.se/article/early-versus-late-initiation-gh-replacement-adult-onset-hypopituitarism - 2025-10-19

Increases in the rates of primary and revision knee replacement are reducing: a 15-year registry study across 3 continents

Rates of knee replacement (KR) are increasing worldwide. Based on population and practice changes, there are forecasts of a further exponential increase in primary knee replacement through to 2030, and a corresponding increase in revision knee replacement. We used registry data to document changes in KR over the past 15 years, comparing practice changes across Sweden, Australia, and the United Sta

https://www.lupop.lu.se/article/increases-rates-primary-and-revision-knee-replacement-are-reducing-15-year-registry-study-across-3 - 2025-10-19

Formas' annual open call 2018 is now open

In the annual open call Formas welcomes applications within its three areas of responsibility - Environment, Agricultural Sciences and Spatial Planning. The purpose of the call is to enable researchers to address self-identified research needs and is divided into three sub-calls:Research and development projectsResearch and development projects for future research leadersMobility grantsThe latter

https://www.lupop.lu.se/article/formas-annual-open-call-2018-now-open - 2025-10-19

Association of acute myocardial infarction with influenza: A nationwide observational study

Influenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration. Read more at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236866

https://www.lupop.lu.se/article/association-acute-myocardial-infarction-influenza-nationwide-observational-study - 2025-10-19

Patterns of urinary albumin and IgM associate with markers of vascular ageing in young to middle-aged individuals in the Malmö offspring study

Increased urinary excretion of IgM and low-grade albuminuria are associated with increased risk of cardiovascular morbidity and mortality. The objective of this study was to investigate the association between urinary IgM, albuminuria, and vascular parameters reflecting arterial structure and function. Read more at https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01638-3

https://www.lupop.lu.se/article/patterns-urinary-albumin-and-igm-associate-markers-vascular-ageing-young-middle-aged-individuals - 2025-10-19

Mental health and academic performance: a study on selection and causation effects from childhood to early adulthood

An inverse relationship between mental health and academic achievement is a well-known phenomenon in the scientific literature. However, how and when this association develops is not fully understood and there is a lack of longitudinal, population-based studies on young children. Early intervention is important if associations are to be found already during childhood. The aim of the present study

https://www.lupop.lu.se/article/mental-health-and-academic-performance-study-selection-and-causation-effects-childhood-early - 2025-10-19

Reversal Treatment in Oral Anticoagulant-Related Intracerebral Hemorrhage—An Observational Study Based on the Swedish Stroke Register

Intracerebral hemorrhage (ICH) is the most serious adverse effect of oral anticoagulant (OAC) treatment. The effect of OAC reversal therapy on outcome is uncertain. We compared 90-day survival and functional outcome in patients with OAC-ICH who received OAC reversal therapy with those who did not. Read more at https://www.frontiersin.org/articles/10.3389/fneur.2020.00760/full

https://www.lupop.lu.se/article/reversal-treatment-oral-anticoagulant-related-intracerebral-hemorrhage-observational-study-based - 2025-10-19