Published 30 September 2020 Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor express

https://www.lupop.lu.se/article/statin-use-hmgcr-expression-and-breast-cancer-survival-malmo-diet-and-cancer-study - 2025-07-05

Published 30 September 2020 With the increased number of cancer survivors, it is necessary to explore the effect of cancer and its treatments on pregnancy outcomes, such as preterm birth, which seriously endangers the health of offspring. We aimed to explore the risk of being born preterm among offspring of cancer survivors. Read more at https://www.frontiersin.org/articles/10.3389/fonc.2020.01352

https://www.lupop.lu.se/article/risk-being-born-preterm-offspring-cancer-survivors-national-cohort-study - 2025-07-05

Published 1 October 2020 The Swedish National Quality Registries (NQRs) contain individual-level health care data for specific patient populations, or patients receiving specific interventions. Approximately 90% of the 105 Swedish NQRs include any patient-reported outcome measure, with EQ-5D being the most common. As there has been no general overview of EQ-5D data within the NQRs, this study fill

https://www.lupop.lu.se/article/collection-and-use-eq-5d-follow-decision-making-and-quality-improvement-health-care-case-swedish - 2025-07-05

Published 1 October 2020 To determine development of new and worsening meniscal damage over 5 years after acute anterior cruciate ligament (ACL) injury comparing rehabilitation plus early ACL reconstruction (’earlyACLR’) versus rehabilitation with optional delayed ACL reconstruction (’optional-delayed-ACLR’). Read more at https://bjsm.bmj.com/content/bjsports/early/2019/10/25/bjsports-2019-101125.

https://www.lupop.lu.se/article/does-early-anterior-cruciate-ligament-reconstruction-prevent-development-meniscal-damage-results - 2025-07-05

Published 2 October 2020 Housing adaptation aims to enable clients to live independently in their own homes. Studies focusing on participation in everyday life following a housing adaptation are lacking and needed. This study aimed to explore housing adaptation clients' experiences of participation in everyday life before and after a housing adaptation, through the lens of a housing adaptation, us

https://www.lupop.lu.se/article/participation-everyday-life-and-after-housing-adaptation - 2025-07-05

Published 2 October 2020 This study explored factors associated with interest in taking PrEP among men who have sex with men (MSM) attending HIV testing venues in Sweden. Data from 658 HIV-negative respondents, surveyed by a questionnaire at six sites, were analyzed descriptively and by univariable and multivariable logistic regression. Read more at https://link.springer.com/article/10.1007/s10508

https://www.lupop.lu.se/article/interest-taking-hiv-pre-exposure-prophylaxis-associated-behavioral-risk-indicators-and-self - 2025-07-05

Published 3 October 2020 Health impact assessments of differential air pollution rely on epidemiologically established relationships between concentration levels where people are exposed and adverse health outcomes. To assess air pollution concentrations, land use regression is commonly used. However, an alternative tool is dispersion modelling, where a detailed inventory of pollution sources toge

https://www.lupop.lu.se/article/particle-concentrations-dispersion-modelling-and-evaluation-southern-sweden - 2025-07-05

Published 2 October 2020 While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. Read more at https://journals.sagepub.com/doi/full/10.1177/2396987320932069

https://www.lupop.lu.se/article/risk-factors-intracerebral-haemorrhage-results-prospective-population-based-study - 2025-07-05

Published 3 October 2020 It is discussed whether fetal scalp stimulation (FSS) test is a reliable complimentary tool to cardiotocography (CTG) to assess fetal wellbeing during labor. The test is based on the assumption that a well-oxygenated fetus, in contrast to the depressed fetus, will respond to a certain stimulus. The aim of this study was to investigate the effectiveness of the FSS-test. Rea

https://www.lupop.lu.se/article/effectiveness-fetal-scalp-stimulation-test-assessing-fetal-wellbeing-during-labor-retrospective - 2025-07-05

Published 3 October 2020 Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of population-based studies. Read more at https://pubmed.ncbi.nlm.nih.gov/31506250/

https://www.lupop.lu.se/article/surgical-complications-postchemotherapy-retroperitoneal-lymph-node-dissection-nonseminoma-germ-cell - 2025-07-05

Published 5 October 2020 The EOSC-Nordic project aims to facilitate the coordination of EOSC relevant initiatives within the Nordic and Baltic countries and exploit synergies to achieve greater harmonisation at policy and service provisioning across these countries, in compliance with EOSC agreed standards and practices. The project brings together a strong consortium of 24 complementary partners

https://www.lupop.lu.se/article/d41-assessment-fair-uptake-among-regional-digital-repositories - 2025-07-05

Published 5 October 2020 The use of primary care electronic health records for research is abundant. The benefits gained from utilising such records lies in their size, longitudinal data collection and data quality. However, the use of such data to undertake high quality epidemiological studies, can lead to significant challenges particularly in dealing with misclassification, variation in coding

https://www.lupop.lu.se/article/data-extraction-epidemiological-research-dexter-novel-tool-automated-clinical-epidemiology-studies - 2025-07-05

Published 6 October 2020 Medical Education research suffers from several methodological limitations including too many single institution, small sample-sized studies, limited access to quality data, and insufficient institutional support. Increasing calls for medical education outcome data and quality improvement research have highlighted a critical need for uniformly clean and easily accessible d

https://www.lupop.lu.se/article/development-and-maintenance-medical-education-research-registry - 2025-07-05

Published 6 October 2020 In the Asian region, no international organ transplantation registry exists. Individual centers maintain their own database, or some countries developed a national registration system. To promote collaboration among Asian transplantation societies, the Asian Society of Transplantation (AST) has developed an international transplantation registry for the Asian countries tha

https://www.lupop.lu.se/article/development-asian-transplant-registry-under-asian-society-transplantation - 2025-07-05

Published 7 October 2020 Clinical trials are the standard approach for evaluating new treatments, but may lack the power to assess rare outcomes. Trial results are also necessarily restricted to the population considered in the study. The availability of routinely collected healthcare data provides a source of information on the performance of treatments beyond that offered by clinical trials, but

https://www.lupop.lu.se/article/bayesian-hierarchical-approach-multiple-outcomes-routinely-collected-healthcare-data - 2025-07-05

Published 7 October 2020 Missing data due to loss to follow‐up or intercurrent events are unintended, but unfortunately inevitable in clinical trials. Since the true values of missing data are never known, it is necessary to assess the impact of untestable and unavoidable assumptions about any unobserved data in sensitivity analysis. This tutorial provides an overview of controlled multiple imputa

https://www.lupop.lu.se/article/sensitivity-analysis-clinical-trials-missing-continuous-outcome-data-using-controlled-multiple - 2025-07-05

Published 8 October 2020 With heighted interest in causal inference based on real‐world evidence, this empirical study sought to understand differences between the results of observational analyses and long‐term randomized clinical trials. We hypothesized that patients deemed “eligible” for clinical trials would follow a different survival trajectory from those deemed “ineligible” and that this fa

https://www.lupop.lu.se/article/empirical-use-causal-inference-methods-evaluate-survival-differences-real-world-registry-vs-those - 2025-07-05

Published 8 October 2020 Bivariate observations of binary and ordinal data arise frequently and require a bivariate modeling approach in cases where one is interested in aspects of the marginal distributions as separate outcomes along with the association between the two. We consider methods for constructing such bivariate models based on latent variables with logistic marginals and propose a mode

https://www.lupop.lu.se/article/bivariate-logistic-regression-model-based-latent-variables - 2025-07-05

Published 9 October 2020 Many diseases such as cancer and heart diseases are heterogeneous and it is of great interest to study the disease risk specific to the subtypes in relation to genetic and environmental risk factors. However, due to logistic and cost reasons, the subtype information for the disease is missing for some subjects. In this article, we investigate methods for multinomial logist

https://www.lupop.lu.se/article/multinomial-logistic-regression-missing-outcome-data-application-cancer-subtypes - 2025-07-05

Published 9 October 2020 The aim of the study was to examine the Family and School Psychosocial Environment (FSPE) questionnaire in relation to a possible genotype-environment correlation and genetic mediation between the FSPE variables and personality variables, assessed by the Junior Eysenck Personality Questionnaire. A sample of 506 Swedish children aged 10-20 years from 253 families were recru

https://www.lupop.lu.se/article/genotype-environment-correlation-and-its-relation-personality-twin-and-family-study - 2025-07-05