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Urbana experiment framställs ofta som motorer för innovation i städers utveckling. Men bakomvisionerna om nytänkande döljer sig en mer grundläggande fråga: hur görs osäkerhet och riskhanterbara i organisationer som samtidigt förväntas vara stabila, ansvarstagande och förutsägbara?Denna rapport argumenterar för att risk inte är ett hinder för urbana experiment – den är en centraldel av dem. Genom a
To address current unsustainable levels of consumption, scholars have increasingly turned to the concept of sufficiency, emphasising an absolute reduction in consumption levels as a pathway towards sustainability. However, the concept of sufficiency-oriented consumption remains theoretically underdeveloped and empirically fragmented. Existing research has generated valuable insights into specific To address current unsustainable levels of consumption, scholars have increasingly turned to the concept of sufficiency, emphasising an absolute reduction in consumption levels as a pathway towards sustainability. However, the concept of sufficiency-oriented consumption remains theoretically underdeveloped and empirically fragmented. Existing research has generated valuable insights into specific
This subsection comprises two main topics. It first assesses the evidence for the contribution of terrestrial animal source food (TASF) to household consumption, as well as the direct and indirect pathways between household TASF consumption and food security and dietary quality. It then discusses the connections between various forms of the direct marketing of TASF and topics such as household fo
Background: Adjunctive corticosteroid therapy appears to be beneficial for adults with severe community-acquired pneumonia (CAP), but data on Mycoplasma pneumoniae CAP are limited. This study aimed to evaluate if adjunctive betamethasone reduced time to resolution of hypoxaemia in adults hospitalised with M. pneumoniae CAP. Methods: An open-label, multicentre, randomised, controlled trial was cond
School absenteeism is linked to adverse academic, social, and mental health outcomes, yet few early interventions have been tested in Nordic contexts. This pilot study examined the preliminary effectiveness of the Early Absenteeism Guide for Lifelong Education (EAGLE), a school initiated, parent-focused intervention targeting emerging absenteeism among children. Nine students in preschool to third
Background: Finding new ways of treating bacterial infections is essential. The NlpD protein, which inhibits RNA polymerase II (Pol II), has shown therapeutic efficacy against urinary tract infection. This study investigated the mechanism of Pol II inhibition and protection by NlpD and its LytM peptide. Methods: Recombinant NlpD and LytM were screened for interactions with constituents of the Pol
Urinary tract infections offer an important and highly relevant model to understand innate immune-mediated protection against mucosal infection and innate immune genetics of susceptibility, including promoter polymorphisms reducing Toll-like receptor (TLR) and interferon regulatory factor expression. Whereas virulent Escherichia coli causes severe, potentially life-threatening disease by breaking
People with peripheral arterial disease (PAD) of the lower limbs are at very high risk of cardiovascular events and therefore the cornerstone of their management is medical therapy and behaviour modification to reduce that risk. The risk of limb loss (through major amputation) is low in people with asymptomatic PAD or intermittent claudication with only a few patients progressing to the most sever
The aim of this study was to evaluate one-year clinical performance and safety of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) used as a bridging stent in fenestrated and branched endovascular aortic repair (FEVAR and BEVAR). This narrative review summarizes one-year outcomes from two multicenter European registries, EXPAND and EMBRACE. Outcomes are presented separate
We explore how top-down policy directionalities are implemented differently across space and the challenges this comes with, based on an analysis of the European Union's amended Waste Framework Directive (WFD), which demands separate textile waste collection. Based on research in Germany and Sweden, we examine the policy implementation by municipal actors, its resulting effects, how different stak
In this chapter we focus on genetic forms of myoclonus and this includes inborn errors of metabolism or metabolic disorders as well. The latter are of course also genetic disorders, but are often considered as a separate group, because for some of them treatment of the underlying metabolic defect is possible. In the chapter, both childhood-onset and adult-onset disorders will be discussed, and all
OBJECTIVES: Rheumatoid arthritis (RA) can be life-changing, requiring long-term treatment to control disease activity. It is therefore important to gain knowledge about patients' experiences of living with RA after 1 to 2 years of disease-modifying antirheumatic drug (DMARD) treatment.METHODS: This qualitative study used an inductive approach. Interviews were conducted with 22 patients with RA in
INTRODUCTION: Benzo[a]pyrene (BaP) is a toxic polycyclic aromatic hydrocarbon known as an exogenous AhR ligand. This study investigates the role of BaP in inducing immune checkpoint expression in lung adenocarcinoma (LUAD) and the underlying mechanisms involving the aryl hydrocarbon receptor (AhR) and tryptophan (Trp) metabolism.METHODS: We assessed the expression of immune checkpoint molecules, i
Lichens are commensal organisms that contain secondary metabolites such as atranorin, which have intrinsic bioactive properties, including anticancer effects. The present study aimed to investigate the therapeutic potential and molecular mechanisms of atranorin and its hydrolytic derivatives in monotherapy and in combination treatment with temozolomide in glioma. The effects of atranorin on glioma
The anticancer therapeutic effects of usnic acid (UA), a lichen secondary metabolite, have been demonstrated in vitro and in vivo. However, the mechanism underlying the anticancer effect of UA remains to be clarified. In this study, the target protein of UA was identified using a UA-linker-Affi-Gel molecule, which showed that UA binds to the 14-3-3 protein. UA binds to 14-3-3, causing the degradat
δ-Catenin is overexpressed in human cancers, including prostate, breast, lung, and ovarian cancers. Therefore, detection of δ-catenin level in patient specimens can be used as a diagnostic marker for the cancer screening. In laboratories, δ-catenin levels have been analyzed by western blot, which requires multiple procedures and is incapable of multiplex analysis of a target protein from a single
Colorectal cancer (CRC) is the third most deadly type of cancer in the world and continuous investigations are required to discover novel therapeutics for CRC. Induction of apoptosis is one of the promising strategies to inhibit cancers. Here, we have identified a novel compound, Libertellenone T (B), isolated from crude extracts of the endolichenic fungus from Pseudoplectania sp. (EL000327) and i
Endolichenic fungi are host organisms that live on lichens and produce a wide variety of secondary metabolites. Colorectal cancer stem cells are capable of self-renewal and differentiation into cancer cells, which makes cancers difficult to eradicate. New alternative therapeutics are needed to inhibit the growth of tumor stem cells. This study examined the ability of an extract of Jackrogersella s
Marinobazzanan (1), a new bazzanane-type sesquiterpenoid, was isolated from a marine-derived fungus belonging to the genus Acremonium. The chemical structure of 1 was elucidated using NMR and mass spectroscopic data, while the relative configurations were established through the analysis of NOESY data. The absolute configurations of 1 were determined by the modified Mosher's method as well as vibr
