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A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. The author posited that familial syndromes become more organ specific with increasing age at tumour presentation to the point that ve
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabiliti
Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purp
The evolution of epidemiological burden in Imperial Russia and, consecutively, the Union of Soviet Socialist Republics (USSR), took place mostly over the duration of the past century [...].
Background. Randomised trials suggest that therapy with aromatase inhibitors improves survival in breast cancer compared with tamoxifen therapy in postmenopausal cases with hormone receptor positive breast cancer. Whether these results from randomized studies transform into the general population is unknown. We have therefore compared survival for all breast cancer cases in Sweden diagnosed 2000-2
The applications of femtosecond lasers to the diagnostics of combustion and flow field have recently attracted increasing interest. Many novel spectroscopic methods have been developed in obtaining non-intrusive measurements of temperature, velocity, and species concentrations with unprecedented possibilities. In this paper, several applications of femtosecond-laser-based incoherent techniques in
Background. Diabetes may be linked to incidence of different tumor diseases and prognosis through various mechanisms such as the disease itself, hyperglycemia, obesity and anti-diabetes therapy. Material and methods. The study includes all women with BC diagnosed in Sweden between 2000 through 2008 (n=54406). The women had no previous cancer diagnosis during the period of 1958-1999. Dates of birth
We present chemical abundances for the elements carbon, sodium, and fluorine in 15 red giants of the globular cluster M4, as well as six red giants of the globular cluster ω Centauri. The chemical abundances were calculated in LTE via spectral synthesis. The spectra analyzed are high-resolution spectra obtained in the near-infrared region around 2.3 μm with the Phoenix spectrograph on the 8.1 m Ge
Fossil fuel companies’ existence is incompatible with the planet’s survival, says Bill McKibben Paris 2015 will be one step along the line, not the thing that solves all the problemsWe now have solutions we didn’t have 25 years ago, we should deploy them with all possible speed
