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Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments. Galectin-1 and galectin-3 have been proposed to together be involved in all 10 hallmarks, suggesting that development of a combined galectin-1/3 inhibitor would be beneficial. Specificity toward galectin-1 or -3 c
Att skapa fasta förbindelser mellan länder genom att bygga broar eller tunnlar är mycket kostsamt, men politiska beslutsfattare hoppas i allmänhet att dessa gigantiska infrastrukturprojekt ska öka internationella handelsflöden. Vi utnyttjar öppnandet av Öresundsbron för att testa om det stämmer. Vårt forskningsprojekt visar att Sverige och Danmark handlar ca 25 procent mer med varandra än man sku
Sustainability standards and ratings do not generate enough information for businesses to understand their environmental impacts across scales and create mitigation plans to avoid further transgression of planetary boundaries.
Among historians and archaeologists, the medieval towns of Roskilde and Lund have been perceived as almost twin towns. Both were founded in the late 10th century, with bishop’s seats established in the 11th century. Both quickly rose to become the most politically, economically, and culturally important ecclesiastical centres in southern Scandinavia, with similar urban landscapes dominated by nume
Objectives: To evaluate the impact of the 2018 switch from PCV13 to PCV10 in Sweden’s childhood immunisation programme on the serotype distribution of Streptococcus pneumoniae.MethodsRespiratory tract (RT) S. pneumoniae isolates (n=1615; 2020–2023) were serotyped, tested for antimicrobial susceptibility and compared with invasive pneumococcal disease (IPD) isolates (n=397) and PCV13-era data (2016
Electrostatic energy plays a pivotal role in the minimization of the free energy of self-assembling oppositely charged ions. This is a fundamental principle that guides the formation of aggregates and the separation of phases characterized by a stoichiometric balance between the opposite charges. However, this study unveils the self-assembly of catanionic nanotubes from a mixture of oppositely cha
This paper explores guldgubbar, small gold foil figures from Vendel Period Scandinavia (c. 550–800 CE), through a new materialist lens, moving beyond representational interpretations rooted in Cartesian thought, that usually frames images to be in stasis. Instead of seeking a singular meaning, the study focuses on the figures’ materiality, affective qualities, and ontological openness. Drawing on
port framstår gärna som något spontant, kroppsligt och i någon mening frikopplat från ekonomi: prestationer på planen, publikens jubel och dramatiken i en direktsändning. Men modern idrott är i själva verket nära sammanvävd med marknadsekonomins förutsättningar. Exempelvis är den utrustning som används av såväl amatörer som professionella idrottsutövare ofta resultatet av betydande investeringar i
Ground truth datasets play a fundamental role as reference values in the training and evaluation of machine learning models. This position paper argues that ground truths are not neutral objective measurements that are naturally given, but instead that they are constructed by arrangements of humans and technologies. We argue that the ML community will benefit from articulating and discussing these
