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Pituitary tumours, originating from endocrine cells of the anterior pituitary, are quite common, and in most cases well-controlled by surgery or medical treatment. However, a small subset of pituitary tumours presents with multiple local recurrences or tumour progression despite combined surgical, medical or radiotherapeutic treatment. These are known as aggressive pituitary tumours (APT); also ca

INTRODUCTION: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated associations between SV2A concentrations in the brain and cerebrospinal fluid (CSF). METHODS: Twenty-one participants with early AD and 7 cognitively normal (CN) individua

We report 23 lichenicolous fungi new to Sweden, among these, one is new to Europe, 21 are new to Fennoscandia, and two are newly reported for Norway. This article focuses only on mitosporic fungi. The newly reported species are Acremonium pertusariae, Cladophialophora dimorphospora, Cladosporium licheniphilum, Corynespora laevistipitata, Didymocyrtis cladoniicola, D. grumantiana, Ellisembia lichen

The rapid growth of smart logistics, driven by IoT devices and data-intensive applications, necessitates secure, scalable, and efficient computing frameworks. As the edge-fog-cloud (EFC) paradigm supports real-time data processing, it faces significant security threats and attacks, including privacy risks, data breaches, and unauthorized access. To address these security threats and attacks, block

To address climate change, firms are increasingly forming sustainability alliances. Pursuing sustainability via such alliances is challenging as it means working with multifaceted and not necessarily compatible goals. Moreover, it often requires collaboration among heterogeneous partners outside traditional industrial contexts as well as dealing with wicked problems. This article presents a multip

Background and Aim: Central venous catheters are vital in the peri- and postoperative period for patients undergoing abdominal surgery but are associated with risks such as catheter related infections. Signs of infection, like tenderness and induration at the insertion site, are important to recognize, as they may precede catheter-related infections, but are often neglected. The aim was to compare

Background: Parkinson's disease is a progressive neurodegenerative disorder. Awareness and the evidence supporting the merits of palliative care (PC) approaches to people with Parkinson's disease (PwP) are increasing. Objective: This review aimed to address four key questions related to PC for PwPs and their caregivers: i) What are the indicators for timely access to PC? ii) When should PC be intr

Objective. In patients with axial spondyloarthritis (axSpA) initiating secukinumab (SEC), we aimed to identify baseline (treatment start) predictors of achieving low disease activity (LDA) after 6 months, as measured by the Axial Spondyloarthritis Disease Activity Score using C-reactive protein (ASDAS-CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), as well as treatment contin

Organic luminescent narrowband emitters have emerged as promising candidates for wide-color-gamut displays. However, the comprehensive photo-induced structural and vibrational dynamics responsible for the spectral broadening remain poorly understood. In this study, ultrafast spectroscopy is employed to elucidate the excited state dynamics of a sulfone-embedded narrowband emitter, 2tCPD. An intrins

Regulation of intracellular levels of reactive oxygen species (ROS) remains poorly understood. Aquaporin 3 (AQP3) facilitates the membrane transport of hydrogen peroxide (H2O2), a key ROS signaling molecule. Here we elucidate the molecular mechanism of AQP3 and show that its regulatory properties are both pH dependent and autoregulated by H2O2. Using single particle cryo-electron microscopy, we pr

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurposing is a promising strategy. Here, we used two independent in silico prediction tools including machine

Global water scarcity requires innovative treatment solutions. This presentation explores three membrane-based concepts advancing from idea to pilot scale: stormwater harvesting with micro-/ultrafiltration (MF/UF), direct membrane filtration (DMF) for wastewater treatment, and a hybrid forward osmosis (FO), membrane distillation (MD), and nanofiltration (NF) system for seawater desalination.The EU

Theory and experience exist for much of the components of a combined system with heat recovery ventilation, building and occupant, but the parts are not put together in a comprehensive and analytical way to let the building sector take part of developed and positivistic knowledge that is needed to make predictable and desired dwellings. This project will, together with numerous ongoing projects, a

Membrane technology has revolutionized protein recovery in the food industry, beginning with whey protein extraction via ultrafiltration. This success led to its application in concentrating animal proteins like blood plasma, fish proteins, and albumen. As the protein shift towards plant-based sources grows, membrane processes now enable the industrial recovery of wheat, sunflower, and rapeseed pr

Introduction:The pulp and paper industry is a major global sector, with most mills focused on producing fibres and electricity. Converting these mills into lignocellulosic biorefineries can make them central to a circular bioeconomy. This involves optimizing wood use for fibres, biochemicals, biofuels, and advanced materials, while improving efficiency and reducing waste. This lecture explores mem

Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w

Water scarcity is a growing global challenge, with projections indicating that 40% of the world’s population could face shortages by 2030. At the same time, the transition to renewable energy is essential for reducing carbon emissions, with solar power playing a key role. The DESOLINATION project addresses these challenges by integrating concentrated solar power with advanced membrane processes fo

Most of the key membrane materials used in industry today were developed in the 1960s and 1970s. The dominant materials on the market include polysulfone, polyethersulfone, polyvinylidene fluoride (PVDF), and polyamide. These materials continue to be the backbone of membrane technologies, owing to their well-established performance, durability, and cost-effectiveness. However, despite significant