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Subtle population structure remains a significant concern in genome-wide association studies. Using human height as an example, we show how quantile regression, a natural extension of linear regression, can better correct for subtle population structure due to its inherent ability to adjust for quantile-specific effects of covariates such as principal components. We utilize data from the UK Bioban
X-ray tomography is a well established technique for investigating three-dimensional bulk structures across scales, from macroscopic samples down to their microscopic constituents. The addition of a temporal dimension through dynamic, time-resolved acquisition results in four-dimensional datasets whose complexity often exceeds the processing capabilities of existing image analysis tools. To addres
Rent-seeking does not occur in an empty room, rent-seekers act within an institutional framework. Neither does this framework exist in an empty room, it rests on laws and regulations that are the result of action taken by a variety of agents. When one agent takes steps to change the framework to benefit herself, she will also change the conditions for other agents, some for the better and some for
We present time-resolved three-dimensional measurements of the averaged liquid mass distribution generated by the Spray M from the Engine Combustion Network. The operating condition corresponds to a non-reacting early injection case for spray-guided gasoline injection during the first 200 μs. Few-femtosecond X-rays from a compact laser wakefield accelerator, enable quantitative spray measurements,
Two-dimensional terahertz spectroscopy (2DTS) is a low-frequency analog of two-dimensional optical spectroscopy that is rapidly maturing as a probe of a wide variety of condensed matter systems. However, a persistent problem with 2DTS is the long experimental acquisition times, which prevent its broader adoption. A potential solution, requiring no increase in experimental complexity, is signal rec
Balancing selection is a potentially important factor in the maintenance of genetic variation for fitness and, alongside recessive deleterious mutations, the genetic basis of inbreeding depression. Classic population genetics theory predicts that inbreeding restricts the range of conditions leading to balancing selection. For example, in models of heterozygote advantage, the classic theory shows t
Pediatric randomized controlled trials (RCTs) inform decisions concerning the choice of interventions in children and adolescents. To enable the implementation of effective interventions, RCT reports need to provide adequate details on the elements, infrastructure, and delivery of these interventions. Using the 12-item Template for the Intervention Description and Replication (TIDieR) framework, a
The European Union's climate strategy emphasises energy democracy, encouraging citizens to participate actively in energy production and consumption as part of the transition to climate neutrality by 2050. This chapter explores the role of energy communities (ECs) in advancing energy democracy, particularly within Sweden's centralised energy system. ECs offer citizens a pathway to collective owner
INTRODUCTION: Patients with non-small cell lung cancer (NSCLC) faced an elevated risk for severe COVID-19 outcomes and were prioritized for early vaccination. However, immune responses to SARS-CoV-2 vaccines remain poorly characterized in this group, especially in patients receiving immune checkpoint inhibitor PD-1/PDL-1 (ICI) therapy.MATERIALS AND METHODS: In this prospective observational study,
Despite the multidimensionality of knowledge and technology transfer (KTT), existing quantitative evaluations predominantly focus on a limited range of channels, often resulting from the availability of data rather than theoretical considerations. To address this gap, we leverage unstructured data from university websites to develop indicators that provide a comprehensive view of universities’ KTT
Liturgical life in today's Catholic Church in the Western world is dominated by women, alt-hough the priesthood remains reserved for men. Conservative critics speak of a feminization of worship life, which is said to be a consequence of the liturgical reform implemented after the Second Vatican Council in the 1960s. This movement gained traction in academic youth circles, and although women also j
The chapter examines education and training initiatives aimed at improving dementia care in majority-world settings. It highlights three key programs that promote equitable partnerships between high-income countries (HICs), upper-middle-income countries, and lower and middle-income countries (LMICs). The first initiative is the Atlantic Fellows for Equity in Brain Health fellowship at the Global B
