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The emergence of drug-resistant Gram-positive pathogens, particularlyStaphylococcus aureusandStreptococcus pyogenes, has driven the need for novel antimicrobial agents. This study explores 21 newly synthesized peptidomimetic analogues of cystatin C Nterminal fragment, designed to enhance bioactivity, solubility, and safety. These compounds were evaluated for antimicrobial potency, cytotoxicity, pr
The chromosomes of 13 primary and 4 secondary Rous sarcomas (RSV–SR) in the rat have been studied in fixations directly from the tumour. The general character of the chromosomal spectrum in the primary sarcomas was similar to that of the Rous sarcomas in the mouse and the Chinese hamster. However, normal diploid stemlines were considerably more frequent in the rat sarcomas; among the heteroploid s
A grazing-incidence Rowland spectrometer with a collimating element for resonant inelastic soft X-ray scattering at the Veritas beamline at MAX IV, Lund, Sweden, is presented. The instrument is designed to operate in the 250–950 eV range, providing >30000 resolving power in first order. The inherent temporal resolution of the delay-line detector enables time-resolved experiments on the 270 ps time
Beamline end-stations often require components to move along non-trivial multi-dimensional trajectories in order to fulfill experimental requirements. These trajectories can frequently be realised through well synchronized combined motion of multiple axes with single degrees of freedom, such as linear and rotational actuators. A good example of this is the SCANIA-2D (Segmented Crystal Analyzer wit
This viewpoint advocates for the inclusion of art in global health discourse and practice. We explore four areas in which art can be leveraged to improve global health: (1) to amplify disenfranchised voices, (2) to advance social justice activism, (3) to strengthen communities and individuals, and (4) to improve global health communication. Drawing on community-driven art initiatives, we argue for
We examine how the earlier introduction of compulsory school grades affects the likelihood of receiving a mental disorder diagnosis among Swedish adolescents. We exploit a school reform that shifted the introduction of grades from grade 8 to grade 6, resulting in first exposure to grading at different ages between cohorts. Our results show that girls exposed to earlier grading are more likely to b
Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an
OBJECTIVES: Loneliness and social isolation are major public health concerns that contribute to numerous health consequences. While many interventions effectively reduce loneliness and social isolation, their cost-effectiveness remain unclear. This study aimed to evaluate and consolidate evidence on the cost-effectiveness of interventions addressing loneliness or social isolation.METHODS: We condu
China’s “Ugly-Cute” Soft Power Wave: What’s Behind Its Explosive Popularity Surpassing Japan and South Korea?
Unsustainable resource flows and obscene inequalities are as inherent in the use of green technologies as in that of the fossil fuels they are meant to replace. The notion that the world economy is undergoing a green transformation is based on the illusion that renewable energy is replacing, rather than just adding to, fossil energy consumption. To move beyond this impasse, we must recognize that
Årets rapport innehåller totalt 15 rekommendationer inom tre områden: Kommunen arbetssätt, Naturbaserade lösningar och att Säkra energisystemet. Här presenteras förslagen i sammanfattad form och de mer detaljerade förslagen återfinns under respektive område i rapporten.1. En mer effektiv klimatanpassningRådet föreslår att kommunen bör utveckla arbetssätt för att främja en mer effektiv klimatanpass
This study explores the characteristics of individuals affiliated with violent extremist milieus in Sweden, focusing on far-right, far-left, and Islamic extremist milieus. Firstly, by using a compilation of law enforcement and other Swedish population registers, we describe these milieus along a range of demographic, socioeconomic, criminal, mental health, and familial indicators. We then compare
Background: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arreBackground: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arre
In this paper, we present a framework to identify discrete-time, single-input/single-output, switched linear systems (SISO-SLSs) from input–output data measurements. Continuous state is not assumed to be measured. The key step is a deadbeat observer-based transformation of the SLS model to a switched auto-regressive with exogenous input (SARX) model. Discrete states are estimated by a three-stage
Climate anxiety is gaining increasing attention but how it is related to both impairment and climate change activism through the use of emotion-focused coping strategies is still poorly understood. We conducted two studies to help understand psychological predictors for climate anxiety-related impairment (Study 1) and gain insights into the roles of trait mindfulness and emotion regulation for dif
Soil erosion is a critical process influencing the global carbon cycle. However, erosion-induced carbon changes remain inadequately understood, particularly for soil inorganic carbon (SIC). There is also limited knowledge about the factors influencing soil carbon dynamics during erosion processes. Here we quantify the global translocation of soil organic carbon (SOC) and SIC due to soil erosion us
Quantifying the spatial and temporal patterns of drought characteristics is crucial, given the increasing frequency and intensity of drought events over the past 20 years in China. However, the patterns of drought frequency and duration in different regions and their differences remain unclear. Traditional indices for detecting and quantifying droughts, such as the Standardized Precipitation Evapo
