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Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ratio of free kappa and lambda chains and an increased concentration of the involved chain. This indirect approach has limitations. Mass spectrometric

This paper engages with the concept of periphery, as presented in Tamsma’s classic paper (1972), and reflects upon what has (or has not) changed in our approach to studying peripheries within regional economic geography over the past fifty or so years. In addition to providing reflections across time, it discusses the situation that Tamsma introduces the Netherlands periphery (the North) from the

Transposable elements (TEs) are mobile genetic sequences comprising around 50% of human DNA. TEs shape gene regulatory networks in development, pluripotency and inflammation, and are implicated in a number of neurological disorders. Therefore, TEs are tightly controlled by epigenetic regulators which form a complex repressive network throughout different stages of development. However, while the r

Purpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty ScalePurpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty Scale

Background: Plasma phosphorylated tau217 (p-tau217) is a robust biomarker of Alzheimer's disease (AD) pathology. However, its full potential as a dynamic marker has still not been verified in very old persons, i.e., those with the highest incidence of AD. Objective: To examine the cross-sectional and longitudinal associations between plasma p-tau217 concentration and cerebrospinal fluid (CSF) AD b

Background: Having overweight is increasingly recognized as a risk factor for poor breast cancer (BC) outcomes. Previous studies have linked high body mass index (BMI) to an increased risk of recurrence and higher mortality. While most research has focused on patients treated with adjuvant chemotherapy, this study examines the impact of overweight on recurrence-free survival (RFS) in BC patients t

Background: Pain in childhood is common, but there is an information gap on initial care seeking. Our aim was to determine trends and variations in the consultation prevalence and incidence of musculoskeletal pain, and most common sites of pain, in children and young people presenting to UK primary care. Methods: A national UK primary care database (CPRD Aurum) was used to determine annual prevale

Abstract in Serbian:авне библиотеке све више се препознају не само као местаза приступ књигама и информацијама, већ и као битне друштвене ин-фраструктуре у којима је брига саставни део рада библиотекара. Ипак, начини на које библиотекари практикују бригу остају недовољно истра-жени и недефинисани. Стога овај рад, кроз теоријску призму друштвеног инфраструктурног деловања (друштвеног инфраструктури

Autoimmune diseases occur due to the abnormal response of the adaptive immune system towards the body's tissues, recognizing them as foreign and leading to chronic inflammation and harm to the tissues. Toxicologists and other scientists believe that factors such as genes, surroundings, and lifestyle can make autoimmune diseases more likely. Xenobiotics, such as chemical pollutants, drugs, microbes

BACKGROUND: A child with avoidant/restrictive food intake disorder (ARFID) has a diet so limited that it leads to medical, nutritional, and/or psychosocial problems. ARFID affects both children and their families, often causing parents to feel anxious and isolated. This study aimed to explore the experiences of Swedish parents raising a child with ARFID.METHOD: Data were generated through semi-str

A survey on vaccinations was conducted among patients with chronic inflammatory diseases (CIDs), including inflammatory bowel disease, inflammatory rheumatological diseases, and dermatological diseases (DDs). The objective was to identify differences between established vaccination guidelines and actual practices in healthcare as experienced by patients. Among eligible responders (n = 1434), 57% w

Background Colorectal cancer (CRC) remains a major global health challenge with high morbidity and mortality despite advances in detection and treatment. Dietary polyphenols are secondary metabolites widely found in plant-derived foods and beverages, and have gained attention for their potential in CRC prevention and therapy due to their diverse biological activities. Methods This review synthesiz

Against the backdrop of growing geopolitical challenges, many countries are re-examining international scientific cooperation through the lens of national security. The security turn in research collaboration and exchange in higher education has prompted policy debates over the future of global science. More can be learned about this security turn by examining a society in which national security

Background: Japan lacks efficient assessment tools for occupational balance (OB) in people with mental illness (MI). Aims/objectives: We investigated the test–retest reliability and construct validity of a Japanese version of the Satisfaction with Daily Occupations and Occupational Balance (SDO-OB-J) for people with MI. Methods: SDO-OB-J interviews were conducted twice at a 2-week interval. Result

Employers in Sweden are mandated to take active measures to prevent discrimination against sexual minorities. While it is important that relevant measures are taken, knowledge is lacking about cisgender lesbian, gay, and bisexual (LGB) people’s minority stress experiences at Swedish workplaces. The present work is based on a thematic analysis of interviews with 53 cisgender LGB participants, focus

Offshore carbon capture and storage (CCS) deployment has been hailed as a game changer in the ever-changing climate game in the era of Paris Agreement. In the European Union (EU), rigorous regulation within a legal framework governs cross-border offshore CCS projects, while China adopts a flexible policy-oriented approach. This article employs a multi-method research approach, combining legal doct

Over the years, demand-responsive transport (DRT) and similar concepts have been implemented and tested in different environments and in different configurations. However, many of these transport services have been abandoned, for various reasons. Previous research shows that some of the most important success factors for a DRT service to sustain over the years are low-cost solutions adjusted to a

The Dirichlet–Neumann alternating method is a common domain decomposition method for nonoverlapping domain decompositions without cross-points, and the method has been studied extensively for linear elliptic equations. However, for nonlinear elliptic equations, there are only convergence results for some specific cases in one spatial dimension. The aim of this manuscript is therefore to prove that