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The extensive and very deep ?Jurassic/Cretaceous–Palaeogene sedimentary basins offshore West Greenland have a significant petroleum exploration potential. This is particularly true for the offshore region west of Disko and Nuussuaq where a live petroleum system has been documented for many years. At present, stratigraphic knowledge in this area is almost nonexistent and analogue studies from onsho
During the field campaign in the Nuuk region, one of the objectives was to describe Archaean primary geological environments (Hollis et al. 2006). On Nunatak 1390, which is part of the Tasiusarsuaq terrane (Figs 1, 2), a bimodal volcanic succession is preserved and interpreted as former ocean floor. The field investigation included geological mapping and sampling of the volcanic sequence comprisin
The 7Be(d, α)5Li and 7Be(d, p)8Be*(p 7Li) reactions are studied at 5 MeV/u in the context of the cosmological lithium problem. This work aims to probe the contribution of 7Be destruction mechanisms, particularly through channels that populate intermediate unbound states of 5Li and 8Be. The contribution of 7Be(d, α)5Li(p α) reaction is separated from the 7Be(d, p)8Be*(2α) reaction. The 7Be(d, p)8Be
Anthropogenic noise and artificial light at night (ALAN) are expanding globally, acting as pervasive sensory pollutants that can disrupt wildlife behaviour and reproduction. While most research has focused on diurnal species, the effects of these pollutants on the ecological response of nocturnal predators remain poorly understood. Using data from nine European countries, we investigated the effec
Losses and damages are residual impacts of climate change that occur despite mitigation and adaptation actions. Losses and damages are borderless, albeit experienced differently between and within countries. Although Australia is a high-income country, recent losses and damages have been particularly severe. Over the last eight years, farmers in East Gippsland, Victoria, have been severely affecte
We present the first ever dataset of manually segmented and transcribed Ajami manuscripts written in Fulfulde and Hausa. The term Ajami refers to modified Arabic-script orthographies in Africa. Existing handwritten text recognition (HTR) and optical character recognition (OCR) models for Arabic-script languages perform poorly on West African manuscripts due to a lack of these manuscripts represent
Estuaries are complex environments rich in biodiversity, making it challenging to understand the distribution and occurrence of microplastics due to the multiple variables that can influence the movement of these particles. Based on this, this study evaluated the influence of different environmental aspects on the distribution and transport of microplastics in the surface waters of the Tramandaí R
Complexity and innovation are emerging as fundamental issues for the future of human life and society. To deal with them, different versions of systems thinking have been proposed. However, System-of-Systems (SoS) thinking, based on the biperspectival principle and human reflexivity, has not yet been clearly recognized. The unclear distinction between ‘systems’ and ‘SoS’ thinking often results in
This study investigates the effects of high-frequency temporal light modulation (TLM) on neural activity using functional magnetic resonance imaging (fMRI) in healthy individuals (age 18–50 years). We examined stimulation frequencies both below (50 Hz) and above (≥100 Hz) the perceptible threshold for visual flicker. Our findings revealed that 50 Hz TLM, which is perceived as flickering, leads to
Multiple myeloma (MM) is the second most common blood malignancy, with several lines of evidence supporting an inherited genetic component. Here, we sequenced 177 affected individuals from 128 families, and 170 early-onset MM cases diagnosed before 55 years of age. Samples were identified and collected through nationwide efforts in France, Sweden, and Greece. We focused on rare germline protein tr
We investigate how the anchoring effect—a well-established cognitive bias—influences subjective belief distributions. While prior research extensively examines the impact of anchoring and other biases on point estimates, their effect on the underlying distribution and its higher moments remains unexplored. Using two pre-registered online experiments (N = 1467) and two elicitation methods, we find
Background: Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. Commonly used EV isolation methods either require large sample volumes and long ultracentrifugation times, or else
Compound heterozygosity for strong hypomorphic mutations in the PRKN gene is a common cause of autosomal familial Parkinson's disease (PD). We generated an iPSC cell line from the fibroblasts of a PARKIN protein-deficient early-onset PD female patient, carrying genomic deletions of exon 2 and exons 5–7. This line displays characteristic human iPSC morphology and expression of pluripotency-associat
Indonesia faces a severe plastic pollution crisis driven by extensive plastic usage and inadequate waste management. To effectively address this issue and promote sustainable circularity, it is crucial to understand the dynamics of plastic production, use, and end-of-life management, as well as the interactions among stakeholders throughout the plastics lifecycle. Without such a comprehensive unde
The fate of the Fermi surface in bulk electron-doped Sr2IrO4 remains elusive, as does the origin and extension of its pseudogap phase. Here, we use high-resolution angle-resolved photoelectron spectroscopy (ARPES) to investigate the electronic structure of Sr2−xLaxIrO4 up to x = 0.2, a factor of two higher than in previous work. We find that the antinodal pseudogap persists up to the highest dopin
Model-based design is an emerging tool for dealing with the uncertain dynamic loads entering wastewater treatment plants (WWTPs). But our understanding about the load-driving population-dynamics is limited. Therefore, we studied if mobility data (mobile telecommunications data) could be used to reduce uncertainties during design. Mobility data from Uppsala, Sweden between 2019–2022 clearly quantif
Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c
Cigarette smoke (CS), a major driver of lung cancer (LC), promotes epithelial-mesenchymal transition (EMT) and stemness resulting in metastasis, therapy resistance, and recurrence, but the precise mechanism is elusive. Building on our earlier identification of Runt related transcription factor-2 (RUNX2) and Galectin-3 (Gal-3) as mediators of CS-induced EMT, in this study, we aimed to identify a po
Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und
We study a class of radially symmetric Coulomb gas ensembles at inverse temperature β=2, for which the droplet consists of a number of concentric annuli, having at least one bounded “gap” G, i.e., a connected component of the complement of the droplet, which disconnects the droplet. Let n be the total number of particles. Among other things, we deduce fine asymptotics as n→∞ for the edge density a
